Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Charles D, Yeh"'
Autor:
Brianna M. Brooks, Charles D. Yeh, Jeanette Beers, Chengyu Liu, Yu-Shan Cheng, Kirill Gorshkov, Jizhong Zou, Wei Zheng, Catherine Z. Chen
Publikováno v:
Stem Cell Research, Vol 53, Iss , Pp 102387- (2021)
Farber disease is an ultra-rare lysosomal storage disease. Mutations in the N-acylsphingosine amidohydrolase (ASAH1) gene, which encodes for the enzyme acid ceramidase (ACDase), cause ceramides to accumulate in the body. A human induced pluripotent s
Externí odkaz:
https://doaj.org/article/21065c45040d4145a00f1c144a7784bb
Autor:
Francis Aguisanda, Charles D. Yeh, Catherine Z. Chen, Rong Li, Jeanette Beers, Jizhong Zou, Natasha Thorne, Wei Zheng
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 12, Iss 1, Pp 1-13 (2017)
Abstract Background Wolman disease (WD) is a rare lysosomal storage disorder that is caused by mutations in the LIPA gene encoding lysosomal acid lipase (LAL). Deficiency in LAL function causes accumulation of cholesteryl esters and triglycerides in
Externí odkaz:
https://doaj.org/article/25d0521044da4cb0a2c485727e6d6954
Autor:
Jacqueline M. Leung, Charles L. Larson, Catherine Z. Chen, Wei Zheng, Tyson A. Woods, Clayton W. Winkler, Karin E. Peterson, Vinod Nair, Katherine G. Taylor, Charles D. Yeh, Cathryn L. Haigh, Gregory J. Tawa, Durbadal Ojha
Publikováno v:
Nature Microbiology. 6:1398-1409
La Crosse virus (LACV) is a mosquito-borne orthobunyavirus that causes approximately 60 to 80 hospitalized pediatric encephalitis cases in the United States yearly. The primary treatment for most viral encephalitis, including LACV, is palliative care
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d53b47cce790ee922fc9d8ed19f12ec9
https://doi.org/10.1038/s41564-021-00968-y
https://doi.org/10.1038/s41564-021-00968-y
Publikováno v:
Nature Cell Biology. 21:1468-1478
Eukaryotic cells deploy overlapping repair pathways to resolve DNA damage. Advancements in genome editing take advantage of these pathways to produce permanent genetic changes. Despite recent improvements, genome editing can produce diverse outcomes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d9324798ece399370a16f02e26e3261
https://doi.org/10.1038/s41556-019-0425-z
https://doi.org/10.1038/s41556-019-0425-z
Autor:
Durbadal, Ojha, Clayton W, Winkler, Jacqueline M, Leung, Tyson A, Woods, Catherine Z, Chen, Vinod, Nair, Katherine, Taylor, Charles D, Yeh, Gregory J, Tawa, Charles L, Larson, Wei, Zheng, Cathryn L, Haigh, Karin E, Peterson
Publikováno v:
Nature microbiology. 6(11)
La Crosse virus (LACV) is a mosquito-borne orthobunyavirus that causes approximately 60 to 80 hospitalized pediatric encephalitis cases in the United States yearly. The primary treatment for most viral encephalitis, including LACV, is palliative care
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::759fd22d03f2056087daecf88474e96d
https://pubmed.ncbi.nlm.nih.gov/34675384
https://pubmed.ncbi.nlm.nih.gov/34675384
Publikováno v:
Nature Protocols, 15 (5)
Nature protocols, vol 15, iss 5
Nat Protoc
Nature protocols, vol 15, iss 5
Nat Protoc
DISCOVER-seq (discovery of in situ Cas off-targets and verification by sequencing) is a broadly applicable approach for unbiased CRISPR–Cas off-target identification in cells and tissues. It leverages the recruitment of DNA repair factors to double
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fb38a72932c57d8dcb4f49e7f23e96c
https://hdl.handle.net/20.500.11850/412711
https://hdl.handle.net/20.500.11850/412711
Autor:
Jeanette Beers, Francis Aguisanda, Rong Li, Jizhong Zou, Catherine Z. Chen, Wei Zheng, Natasha Thorne, Charles D. Yeh
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 12, Iss 1, Pp 1-13 (2017)
Orphanet Journal of Rare Diseases
Orphanet Journal of Rare Diseases
Background Wolman disease (WD) is a rare lysosomal storage disorder that is caused by mutations in the LIPA gene encoding lysosomal acid lipase (LAL). Deficiency in LAL function causes accumulation of cholesteryl esters and triglycerides in lysosomes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08f22a40ee4461050781b4ba7e3d399e
http://link.springer.com/article/10.1186/s13023-017-0670-9
http://link.springer.com/article/10.1186/s13023-017-0670-9
Autor:
Wei Zheng, Kirill Gorshkov, Charles D. Yeh, Chengyu Liu, Jeanette Beers, Jizhong Zou, Yu-Shan Cheng, Brianna M. Brooks, Catherine Z. Chen
Publikováno v:
Stem cell research
Stem Cell Research, Vol 53, Iss, Pp 102387-(2021)
Stem Cell Research, Vol 53, Iss, Pp 102387-(2021)
Farber disease is an ultra-rare lysosomal storage disease. Mutations in the N-acylsphingosine amidohydrolase (ASAH1) gene, which encodes for the enzyme acid ceramidase (ACDase), cause ceramides to accumulate in the body. A human induced pluripotent s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::981a73a9be8c9cef83a917890aa3301c
https://doi.org/10.1016/j.scr.2021.102387
https://doi.org/10.1016/j.scr.2021.102387
Publikováno v:
Nature cell biology. 21(12)
Eukaryotic cells deploy overlapping repair pathways to resolve DNA damage. Advancements in genome editing take advantage of these pathways to produce permanent genetic changes. Despite recent improvements, genome editing can produce diverse outcomes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9311b218b669127017a4644305ba07cc
https://pubmed.ncbi.nlm.nih.gov/31792376
https://pubmed.ncbi.nlm.nih.gov/31792376
Autor:
Catherine Z. Chen, Benson Yh. Cheng, Emilio Ortiz-Riaño, Juan Carlos de la Torre, Beatrice Cubitt, Charles D. Yeh, Wei Zheng, N.O.E. Southall, Luis Martinez-Sobrido, Yu-Jin Kim
Publikováno v:
Antiviral Research
The mammarenavirus Lassa (LASV) is highly prevalent in West Africa where it infects several hundred thousand individuals annually resulting in a high number of Lassa fever (LF) cases, a febrile disease associated with high morbidity and significant m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d332b1d67ff5a2844a810e2e11ac413
https://doi.org/10.1016/j.antiviral.2019.104667
https://doi.org/10.1016/j.antiviral.2019.104667