Zobrazeno 1 - 10
of 245
pro vyhledávání: '"Charles D, Cox"'
Autor:
Haoqing Jerry Wang, Yao Wang, Seyed Sajad Mirjavadi, Tomas Andersen, Laura Moldovan, Parham Vatankhah, Blake Russell, Jasmine Jin, Zijing Zhou, Qing Li, Charles D. Cox, Qian Peter Su, Lining Arnold Ju
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract The microgeometry of the cellular microenvironment profoundly impacts cellular behaviors, yet the link between it and the ubiquitously expressed mechanosensitive ion channel PIEZO1 remains unclear. Herein, we describe a fluorescent micropipe
Externí odkaz:
https://doaj.org/article/832d8eaab86449c8bbae7b7e5b509f79
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-9 (2023)
Abstract Mechanosensitive (MS) ion channels are a ubiquitous type of molecular force sensor sensing forces from the surrounding bilayer. The profound structural diversity in these channels suggests that the molecular mechanisms of force sensing follo
Externí odkaz:
https://doaj.org/article/fbac2488ace941f58236264c06941d96
Autor:
Shilong Yang, Xinwen Miao, Steven Arnold, Boxuan Li, Alan T. Ly, Huan Wang, Matthew Wang, Xiangfu Guo, Medha M. Pathak, Wenting Zhao, Charles D. Cox, Zheng Shi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
This study demonstrates that the curvature of the cell membrane directly regulates the spatial distribution of Piezo1, a widely expressed mechanosensitive ion channel. Piezo1 may flatten upon activation and can mechanically inhibit membrane dynamics
Externí odkaz:
https://doaj.org/article/7c6e40022e03487d9d2a0edfa393acce
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Mechanosensitive (MS) ion channels are primary transducers of mechanical force into electrical and/or chemical intracellular signals. Many diverse MS channel families have been shown to respond to membrane forces. As a result of this intimat
Externí odkaz:
https://doaj.org/article/b594b8b303cf425385198e18898108cc
Modified N-linked glycosylation status predicts trafficking defective human Piezo1 channel mutations
Autor:
Jinyuan Vero Li, Chai-Ann Ng, Delfine Cheng, Zijing Zhou, Mingxi Yao, Yang Guo, Ze-Yan Yu, Yogambha Ramaswamy, Lining Arnold Ju, Philip W. Kuchel, Michael P. Feneley, Diane Fatkin, Charles D. Cox
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-17 (2021)
Li et al. investigates the role of N-linked glycosylation for the function of mechanosensitive ion channel Piezo1. They show that disease-linked loss of function mutations in Piezo1 that are trafficking defective lack N-linked glycosylation.
Externí odkaz:
https://doaj.org/article/838c42e3bd25417ab25bf8adfdc60922
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract We present mathematical simulations of shapes of red blood cells (RBCs) and their cytoskeleton when they are subjected to linear strain. The cell surface is described by a previously reported quartic equation in three dimensional (3D) Cartes
Externí odkaz:
https://doaj.org/article/c4ea9182246c41c19c143aaea2d7f346
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract We present the first direct nuclear magnetic resonance (NMR) evidence of enhanced entry of Ca2+ ions into human erythrocytes (red blood cells; RBCs), when these cells are mechanically distorted. For this we loaded the RBCs with the fluorinat
Externí odkaz:
https://doaj.org/article/cdb8c935e89246b4977bec8744a49a67
Autor:
Pak Hin Chow, Charles D. Cox, Jinxin V. Pei, Nancy Anabaraonye, Saeed Nourmohammadi, Sam W. Henderson, Boris Martinac, Osheiza Abdulmalik, Andrea J. Yool
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2022)
In sickle cell disease (SCD), the pathological shift of red blood cells (RBCs) into distorted morphologies under hypoxic conditions follows activation of a cationic leak current (Psickle) and cell dehydration. Prior work showed sickling was reduced b
Externí odkaz:
https://doaj.org/article/7b261274538d4f4182c6018c8b54709c
Autor:
Shilong Yang, Xinwen Miao, Steven Arnold, Boxuan Li, Alan T. Ly, Huan Wang, Matthew Wang, Xiangfu Guo, Medha M. Pathak, Wenting Zhao, Charles D. Cox, Zheng Shi
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/f8d7dd5290874c39834e2311f172d935
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Missense mutations in the gene that encodes for the mechanically-gated ion channel Piezo1 have been linked to a number of diseases. Gain-of-function variants are linked to a hereditary anaemia and loss-of-function variants have been linked to general
Externí odkaz:
https://doaj.org/article/fbea43c946d1477daeeae839dbfebaee