Zobrazeno 1 - 10
of 447
pro vyhledávání: '"Charles Coombes"'
Autor:
Ylenia Perone, Aaron J. Farrugia, Alba Rodríguez-Meira, Balázs Győrffy, Charlotte Ion, Andrea Uggetti, Antonios Chronopoulos, Pasquale Marrazzo, Monica Faronato, Sami Shousha, Claire Davies, Jennifer H. Steel, Naina Patel, Armando del Rio Hernandez, Charles Coombes, Giancarlo Pruneri, Adrian Lim, Fernando Calvo, Luca Magnani
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
ERα breast cancer can relapse to metastatic disease following endocrine therapy. Here, the authors find that when aromatase inhibitor treatment resistance develops, epigenomic reprogramming drives Keratin-80 upregulation via SREBP1, and promotes cyt
Externí odkaz:
https://doaj.org/article/89df65835066448cbf1f8b48e72f3298
Autor:
Ylenia Perone, Aaron J. Farrugia, Alba Rodríguez-Meira, Balázs Győrffy, Charlotte Ion, Andrea Uggetti, Antonios Chronopoulos, Pasquale Marrazzo, Monica Faronato, Sami Shousha, Claire Davies, Jennifer H. Steel, Naina Patel, Armando del Rio Hernandez, Charles Coombes, Giancarlo Pruneri, Adrian Lim, Fernando Calvo, Luca Magnani
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/fff95096dfe94029b18485fd44cda673
Autor:
Erika Dorado, Maria Luisa Doria, Anika Nagelkerke, James S. McKenzie, Stefania Maneta‐Stavrakaki, Thomas E. Whittaker, Jeremy K. Nicholson, Raoul Charles Coombes, Molly M. Stevens, Zoltan Takats
Publikováno v:
Journal of Extracellular Vesicles, Vol 13, Iss 3, Pp n/a-n/a (2024)
Abstract Extracellular vesicles (EVs), including exosomes and microvesicles, mediate intercellular communication in cancer, from development to metastasis. EV‐based liquid biopsy is a promising strategy for cancer diagnosis as EVs can be found in c
Externí odkaz:
https://doaj.org/article/3beb3e701f444de2bbeb69d2b7c40c5c
Autor:
Anisha Ramessur, Bana Ambasager, Iker Valle Aramburu, Freddie Peakman, Kelly Gleason, Christoph Lehmann, Venizelos Papayannopoulos, Raoul Charles Coombes, Ilaria Malanchi
Publikováno v:
Breast Cancer Research, Vol 25, Iss 1, Pp 1-12 (2023)
Abstract Purpose An elevated number of circulating neutrophils is a poor prognostic factor for breast cancer, where evidence of bone marrow cancer-dependent priming is found. However, how early this priming is detectable remains unclear. Patients and
Externí odkaz:
https://doaj.org/article/ef57165dca85401589110eed0e990aa2
Publikováno v:
Molecular Cancer, Vol 5, Iss 1, p 8 (2006)
Abstract Background Cyclin D1 is an important regulator of G1-S phase cell cycle transition and has been shown to be important for breast cancer development. GSK3β phosphorylates cyclin D1 on Thr-286, resulting in enhanced ubiquitylation, nuclear ex
Externí odkaz:
https://doaj.org/article/2bf287de19254186a02a7da72bb2d617
Autor:
Rebecca C Allsopp, Karen Page, Bana Ambasager, Marc K Wadsley, Emmanuel Acheampong, Tumisang P Ntereke, Qi Guo, Gurdeep Matharu Lall, Kelly L T Gleason, Evie Wren, Georgios Nteliopoulos, Amelia J Rushton, R Charles Coombes, Jacqueline A Shaw
Publikováno v:
Clinical Chemistry. 69:510-518
Background Somatic copy number alterations (sCNAs) acquired during the evolution of breast cancer provide valuable prognostic and therapeutic information. Here we present a workflow for screening sCNAs using picogram amounts of cell-free DNA (cfDNA)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e944b78ecb25a6e2ffa9168bd02f9cf
https://doi.org/10.1093/clinchem/hvac220
https://doi.org/10.1093/clinchem/hvac220
Autor:
Simak Ali, R. Charles Coombes, Anthony G. M. Barrett, Matthew J. Fuchter, Laki Buluwela, Eric O. Aboagye, Alison Harrod, Silvia Ottaviani, Richard Starkey, Marion Barbazanges, Sebastian H. B. Kroll, Brian W. Slafer, Alexander Bondke, Georgina P. Sava, Manikandan Periyasamy, Hetal Patel
In vitro kinase assays demonstrate selectivity of ICEC0942 for CDK7.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3115379f20023b58b11b5bd3f114b3e9
https://doi.org/10.1158/1535-7163.22505256.v1
https://doi.org/10.1158/1535-7163.22505256.v1
Autor:
Simak Ali, R. Charles Coombes, Anthony G. M. Barrett, Matthew J. Fuchter, Laki Buluwela, Eric O. Aboagye, Alison Harrod, Silvia Ottaviani, Richard Starkey, Marion Barbazanges, Sebastian H. B. Kroll, Brian W. Slafer, Alexander Bondke, Georgina P. Sava, Manikandan Periyasamy, Hetal Patel
Recent reports indicate that some cancer types are especially sensitive to transcription inhibition, suggesting that targeting the transcriptional machinery provides new approaches to cancer treatment. Cyclin-dependent kinase (CDK)7 is necessary for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7954b2e0f9b8731f18d462f3b2edad27
https://doi.org/10.1158/1535-7163.c.6537999.v1
https://doi.org/10.1158/1535-7163.c.6537999.v1
Autor:
Eric W.-F. Lam, Stephen S. Myatt, R. Charles Coombes, Julie Millour, Helma D.C. Schwenen, Lara J. Monteiro, Barrie Peck, Jimmy M.-M. Kwok
Supplementary Data from FOXM1 Confers Acquired Cisplatin Resistance in Breast Cancer Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a982c6134ee52906078facde08d639ae
https://doi.org/10.1158/1541-7786.22519287.v1
https://doi.org/10.1158/1541-7786.22519287.v1
Autor:
Simak Ali, R. Charles Coombes, Anthony G. M. Barrett, Matthew J. Fuchter, Laki Buluwela, Eric O. Aboagye, Alison Harrod, Silvia Ottaviani, Richard Starkey, Marion Barbazanges, Sebastian H. B. Kroll, Brian W. Slafer, Alexander Bondke, Georgina P. Sava, Manikandan Periyasamy, Hetal Patel
Figure legends for supplementary Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29e68a2e65994bf8e6171e2a36349138
https://doi.org/10.1158/1535-7163.22505235
https://doi.org/10.1158/1535-7163.22505235