Zobrazeno 1 - 10
of 192
pro vyhledávání: '"Charles Chavkin"'
Publikováno v:
Addiction Neuroscience, Vol 1, Iss , Pp 100005- (2022)
Behavioral stress exposure increases the risk of drug-taking in individuals with substance use disorders by mechanisms involving the dynorphins, which are the endogenous neuropeptides for the kappa opioid receptor (KOR). KOR agonists have been shown
Externí odkaz:
https://doaj.org/article/45a8d0a3757e42a4a025b8bf96b2a8d3
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 14 (2020)
Stress is highly pervasive in humans, impacting motivated behaviors with an enormous toll on life quality. Many of the effects of stress are orchestrated by neuropeptides such as corticotropin-releasing factor (CRF). It has previously been shown that
Externí odkaz:
https://doaj.org/article/87439fc26b8f43e89872c5f4d00e3224
Autor:
Selena S. Schattauer, Benjamin B. Land, Kathryn L. Reichard, Antony D. Abraham, Lauren M. Burgeno, Jamie R. Kuhar, Paul E. M. Phillips, Shao En Ong, Charles Chavkin
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Opioid receptors are important modulators of nociceptive pain. Here the authors show that opioid receptor activation recruits peroxiredoxin 6 (PRDX6) to the receptor-Gαi complex by c-Jun N-terminal kinase, resulting in Gαi depalmitoylation and enha
Externí odkaz:
https://doaj.org/article/663c11deb7974a19a4ce19a91ea13d73
Repeated Administration of Norbinaltorphimine Produces Cumulative Kappa Opioid Receptor Inactivation
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Kappa receptor activation by dynorphins contributes to the anxiogenic, dysphoric, and cognitive disrupting effects of repeated stress, suggesting that kappa receptor antagonists might have therapeutic utility in the treatment of stress disorders. Thr
Externí odkaz:
https://doaj.org/article/21c16e99692b4eceb09f0193512c4e5b
Publikováno v:
PLoS ONE, Vol 4, Iss 12, p e8528 (2009)
Stress is a complex human experience and having both rewarding and aversive motivational properties. The adverse effects of stress are well documented, yet many of underlying mechanisms remain unclear and controversial. Here we report that the anxiog
Externí odkaz:
https://doaj.org/article/6cea70de9a2748a39988c6f095d4b966
Autor:
Andreas Zimmer, Nurulain Zaveri, Yung H. Wong, Hiroshi Ueda, John R. Traynor, Lawrence Toll, Eric J. Simon, Toni S. Shippenberg, Stefan Schulz, Philip S. Portoghese, Jean-Claude Meunier, Dominique Massot, Davide Malfacini, Lee-Yuan Liu-Chen, Mary-Jeanne Kreek, Ian Kitchen, Brigitte Kieffer, Eamonn Kelly, Stephen Husbands, Graeme Henderson, Volker Höllt, Christopher Evans, Lakshmi A. Devi, Brian M. Cox, Mark Connor, Olivier Civelli, MacDonald J. Christie, Charles Chavkin, Girolamo Caló, Michael Bruchas, Anna Borsodi
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2023
Opioid and opioid-like receptors are activated by a variety of endogenous peptides including [Met]enkephalin (met), [Leu]enkephalin (leu), β-endorphin (β-end), α-neodynorphin, dynorphin A (dynA), dynorphin B (dynB), big dynorphin (Big dyn), nocice
Autor:
Rachelle Tran, Antony D. Abraham, Benjamin B. Land, Phillip R. Silva, Harrison M. Fontaine, John F. Neumaier, Carlie Neiswanger, Charles Chavkin
Publikováno v:
Neuropsychopharmacology. 47:891-901
Stress-induced release of dynorphins (Dyn) activates kappa opioid receptors (KOR) in serotonergic neurons to produce dysphoria and potentiate drug reward; however, the circuit mechanisms responsible for this effect are not known. In male mice, we fou
Autor:
T. Andrew Bowdle, Nathan Sackett, Rick Strassman, Thomas F. Murray, Srdjan Jelacic, Charles Chavkin
Publikováno v:
Anesthesiology. 137(6)
Autor:
Katharine J. Liang, Charles Chavkin, Kevin R. Coffey, John F. Neumaier, Joshua H Cohen, Atom J. Lesiak
Publikováno v:
Molecular psychiatry
Serotonin is a key mediator of stress, anxiety, and depression, and novel therapeutic targets within serotonin neurons are needed to combat these disorders. To determine how stress alters the translational profile of serotonin neurons, we sequenced r
Autor:
Jane C. Ballantyne, Charles Chavkin
Publikováno v:
Pain. 161:1945-1948