Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Charles C. Searby"'
Autor:
Shruti V. Patil, Balasankara Reddy Kaipa, Sujata Ranshing, Yogapriya Sundaresan, J. Cameron Millar, Bhavani Nagarajan, Charles Kiehlbauch, Qihong Zhang, Ankur Jain, Charles C. Searby, Todd E. Scheetz, Abbot F. Clark, Val C. Sheffield, Gulab S. Zode
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Mutations in myocilin (MYOC) are the leading known genetic cause of primary open-angle glaucoma, responsible for about 4% of all cases. Mutations in MYOC cause a gain-of-function phenotype in which mutant myocilin accumulates in the endoplas
Externí odkaz:
https://doaj.org/article/30e1fedfb0d445a39df2b98bbdbfd4a5
Autor:
Ying Hsu, Sajag Bhattarai, Jacob M. Thompson, Angela Mahoney, Jacintha Thomas, Sara K. Mayer, Poppy Datta, Janelle Garrison, Charles C. Searby, Luk H. Vandenberghe, Seongjin Seo, Val C. Sheffield, Arlene V. Drack
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 31, Iss , Pp 164-181 (2023)
Blindness in Bardet-Biedl syndrome (BBS) is caused by dysfunction and loss of photoreceptor cells in the retina. BBS10, mutations of which account for approximately 21% of all BBS cases, encodes a chaperonin protein indispensable for the assembly of
Externí odkaz:
https://doaj.org/article/595390ab39c54dacacc20bd00b9764d5
Autor:
Mekhla Singhania, Amira Zaher, Casey F. Pulliam, Khaliunaa Bayanbold, Charles C. Searby, Joshua D. Schoenfeld, Kranti A. Mapuskar, Melissa A. Fath, Bryan G. Allen, Douglas R. Spitz, Michael S. Petronek
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 4, p 2398 (2024)
Cancer cells frequently present elevated intracellular iron levels, which are thought to facilitate an enhanced proliferative capacity. Targeting iron metabolism within cancer cells presents an avenue to enhance therapeutic responses, necessitating t
Externí odkaz:
https://doaj.org/article/226bada5cf3345548216f30713cfa0e3
Autor:
Khaliunaa Bayanbold, Mekhla Singhania, Melissa A. Fath, Charles C. Searby, Jeffrey M. Stolwijk, John B. Henrich, Casey F. Pulliam, Joshua D. Schoenfeld, Kranti A. Mapuskar, Sei Sho, Joseph M. Caster, Bryan G. Allen, Garry R. Buettner, Maria Spies, Prabhat C. Goswami, Michael S. Petronek, Douglas R. Spitz
Publikováno v:
Antioxidants, Vol 12, Iss 11, p 2005 (2023)
The intracellular redox-active labile iron pool (LIP) is weakly chelated and available for integration into the iron metalloproteins that are involved in diverse cellular processes, including cancer cell-specific metabolic oxidative stress. Abnormal
Externí odkaz:
https://doaj.org/article/528679c8946943c59f5691686a352e09
Autor:
Sunny C. Huang, Thomas K. Pak, Cameron P. Graber, Charles C. Searby, Guanghao Liu, Jennifer Marcy, Alexandra K. Yaszemski, Kurt Bedell, Emily Bui, Stanley Perlman, Qihong Zhang, Kai Wang, Val C. Sheffield, Calvin S. Carter
Publikováno v:
PeerJ, Vol 10, p e13277 (2022)
Importance The rise of novel, more infectious SARS-CoV-2 variants has made clear the need to rapidly deploy large-scale testing for COVID-19 to protect public health. However, testing remains limited due to shortages of personal protective equipment
Externí odkaz:
https://doaj.org/article/07ae08480d20405f9c25b8c72f78636c
Autor:
Ramesh B. Kasetti, Pinkal D. Patel, Prabhavathi Maddineni, Shruti Patil, Charles Kiehlbauch, J. Cameron Millar, Charles C. Searby, VijayKrishna Raghunathan, Val C. Sheffield, Gulab S. Zode
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Glaucoma is the leading cause of irreversible blindness affecting over 70 million people worldwide. Here, the authors show that inhibition of chronic ER stress-induced ATF4-CHOP-GADD34 signaling pathway rescues pathology in mouse models of glaucoma,
Externí odkaz:
https://doaj.org/article/066b0588eecd45bc90ad78f0bc0e7443
Autor:
Ramesh B. Kasetti, Prabhavathi Maddineni, Charles Kiehlbauch, Shruti Patil, Charles C. Searby, Beth Levine, Val C. Sheffield, Gulab S. Zode
Publikováno v:
JCI Insight, Vol 6, Iss 5 (2021)
Elevation of intraocular pressure (IOP) due to trabecular meshwork (TM) damage is associated with primary open-angle glaucoma (POAG). Myocilin mutations resulting in elevated IOP are the most common genetic causes of POAG. We have previously shown th
Externí odkaz:
https://doaj.org/article/d48f0fd972a04d0db0dea25165c012ca
Autor:
Jeffrey M. Stolwijk, Kelly C. Falls-Hubert, Charles C. Searby, Brett A. Wagner, Garry R. Buettner
Publikováno v:
Redox Biology, Vol 32, Iss , Pp - (2020)
Selenium is a metalloid trace element essential for maintaining the optimal redox environment in cells and tissues. It is structurally incorporated into over 25 selenoproteins and enzymes. The glutathione peroxidase (GPx) family of enzymes has a crit
Externí odkaz:
https://doaj.org/article/1b2fc01eca9e48348aadcd66a1d7a495
Autor:
Calvin S. Carter, Sunny C. Huang, Charles C. Searby, Benjamin Cassaidy, Michael J. Miller, Wojciech J. Grzesik, Ted B. Piorczynski, Thomas K. Pak, Susan A. Walsh, Michael Acevedo, Qihong Zhang, Kranti A. Mapuskar, Ginger L. Milne, Antentor O. Hinton Jr., Deng-Fu Guo, Robert Weiss, Kyle Bradberry, Eric B. Taylor, Adam J. Rauckhorst, David W. Dick, Vamsidhar Akurathi, Kelly C. Falls-Hubert, Brett A. Wagner, Walter A. Carter, Kai Wang, Andrew W. Norris, Kamal Rahmouni, Garry R. Buettner, Jason M. Hansen, Douglas R. Spitz, E. Dale Abel, Val C. Sheffield
Publikováno v:
Am J Physiol Endocrinol Metab
Carter et al. report that exposure to static magnetic and electric fields (sBE), for as little as 3 days, reverses glucose intolerance and insulin resistance in diet-induced and genetic mouse models of type 2 diabetes (1). They hypothesize that sBE t
Autor:
Deng-Fu Guo, Donald A Morgan, Charles C Searby, Darryl Y Nishmura, Val C Sheffield, Kamal Rahmouni
Publikováno v:
Hypertension. 62
Bardet-Biedl syndrome (BBS) is a pleiotropic autosomal recessive disorder with several features including obesity and hypertension. Systemic knock-out mouse models lacking expression of Bbs2, Bbs4 and Bbs6 genes, and Bbs1 M390R knock-in recapitulated