Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Charles C. Rovetti"'
Autor:
Yi Lu, Jotham Wadsworth Coe, Thomas I. Davis, David W. Schulz, Lorraine A. Lebel, Robert S. Mansbach, Paige Roanne Palmer Brooks, Michael C. Wirtz, Alka Shrikhande, Michael G. Vetelino, Leslie K. Chambers, Eric P. Arnold, Eric Schaeffer, Brian T. O’Neill, Steven B. Sands, and F. David Tingley, James Heym, Carol B. Fox, Huang Jianhua, Charles C. Rovetti, Hans Rollema
Publikováno v:
Modern Drug Synthesis
Herein we describe a novel series of compounds from which varenicline (1, 6,7,8,9-tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine) has been identified for smoking cessation. Neuronal nicotinic acetylcholine receptors (nAChRs) mediate the dep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44d09a810f898eefeb7fda3442e4b30f
https://doi.org/10.1021/jm050069n
https://doi.org/10.1021/jm050069n
Publikováno v:
Psychopharmacology. 148:234-242
Rationale: The cellular effects of nicotine underlying its addictive liability are thought to be mediated by neuronal nicotinic receptors (nACHRs) in the central nervous system. It is believed that densely expressed β2-containing nACHRs in the centr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed1fe8b488d07c4ff8ca6feef5a36268
https://doi.org/10.1007/s002130050047
https://doi.org/10.1007/s002130050047
Publikováno v:
Psychopharmacology. 128:313-319
CP-135,807 [3-(N-methylpyrrolidin-2R-ylmethyl)-5-(3-nitropyrid-2- yl)amino-1H-indole] binds with high affinity to central 5-HT1D receptors, and in functional studies produces dose-dependent decreases in extracellular serotonin. These and other findin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::686d138d4a6498abf17a88d84e573d7d
https://doi.org/10.1007/s002130050139
https://doi.org/10.1007/s002130050139
Autor:
Steven B. Sands, Leslie K. Chambers, Eric Schaeffer, Raymond S. Hurst, Robert S. Mansbach, J. Glowa, Hans Rollema, F. D. Tingley, Charles C. Rovetti, Yi Lu, David W. Schulz, Robert J. Mather, Jotham Wadsworth Coe, Lorraine A. Lebel, Kathryn E. Williams
Publikováno v:
Neuropharmacology. 52(3)
The preclinical pharmacology of the alpha4beta2 nicotinic acetylcholine receptor (nAChR) partial agonist varenicline, a novel smoking cessation agent is described. Varenicline binds with subnanomolar affinity only to alpha4beta2 nAChRs and in vitro f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::923f018ec34038ca039b3bc97c7a5fde
https://pubmed.ncbi.nlm.nih.gov/17157884
https://pubmed.ncbi.nlm.nih.gov/17157884
Publikováno v:
Drug and alcohol dependence. 52(2)
Nicotine serves as a reinforcer and induces a robust discriminative stimulus which is primarily mediated by neuronal nicotinic receptors. As a secondary effect of nicotinic stimulation, nicotine elicits an enhanced release of the biogenic amine neuro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f79c7f59dd4b36396163deb86de8b83b
https://pubmed.ncbi.nlm.nih.gov/9800142
https://pubmed.ncbi.nlm.nih.gov/9800142
Publikováno v:
Psychopharmacology. 124(4)
SR141716A (Sanofi Recherche), a pyrazole derivative with high affinity for rat and human CB1 cannabinoid receptors, has recently been reported to reverse biochemical, physiological and behavioral effects induced by cannabinoid agonists. The present e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::218322ce84cef764e1679c2a6b3f2cb9
https://pubmed.ncbi.nlm.nih.gov/8739546
https://pubmed.ncbi.nlm.nih.gov/8739546
Autor:
Jotham Wadsworth Coe, Hans Rollema, Alka Shrikhande, Lorraine A. Lebel, Steven B. Sands, Carol B. Fox, Paige Roanne Palmer Brooks, Leslie K. Chambers, Charles C. Rovetti, Robert S. Mansbach, Michael C. Wirtz, Brian T. O’Neill, F. David Tingley, David W. Schulz, Thomas I. Davis, Michael G. Vetelino, Eric P. Arnold
Publikováno v:
Biochemical Pharmacology. 78:919
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3676fb96a58f5730104d2c95479cfc08
https://doi.org/10.1016/j.bcp.2009.06.078
https://doi.org/10.1016/j.bcp.2009.06.078