Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Charles C. Query"'
Autor:
Anindita Basak, Charles C. Query
Publikováno v:
Cell Reports, Vol 8, Iss 4, Pp 966-973 (2014)
Although pseudouridine nucleobases are abundant in tRNAs, rRNAs, and small nuclear RNAs (snRNAs), they are not known to have physiologic roles in cell differentiation. We have identified a pseudouridine residue (Ψ28) on spliceosomal U6 snRNA that is
Externí odkaz:
https://doaj.org/article/b392d218a68e41d482c47e88107ef3c3
Autor:
Charles C. Query, Jia Pu, Zhan Ding, Wei Shao, Yu Xian Shen, Yong-Zhen Xu, Zeng Zhang Zheng, Ji Jia Shen, Yu Jie Fan
Publikováno v:
Nucleic Acids Research
Transcription and pre-mRNA splicing are coupled to promote gene expression and regulation. However, mechanisms by which transcription and splicing influence each other are still under investigation. The ATPase Prp5p is required for pre-spliceosome as
Autor:
Matthew J. Gamble, Varun Gupta, Maxim I. Maron, David Shechter, Simone Sidoli, Alyssa D. Casill, Charles C. Query
Protein arginine methyltransferases (PRMTs) are required for the regulation of RNA processing factors. Type I enzymes catalyze mono- and asymmetric dimethylation; Type II enzymes catalyze mono- and symmetric dimethylation. To understand the specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cca87d39fa3b17cc7158f5adc9946cfb
https://doi.org/10.1101/2021.08.20.457069
https://doi.org/10.1101/2021.08.20.457069
Autor:
Maxim I Maron, Alyssa D Casill, Varun Gupta, Jacob S Roth, Simone Sidoli, Charles C Query, Matthew J Gamble, David Shechter
Publikováno v:
eLife
eLife, Vol 11 (2022)
eLife, Vol 11 (2022)
Protein arginine methyltransferases (PRMTs) are required for the regulation of RNA processing factors. Type I PRMT enzymes catalyze mono- and asymmetric dimethylation; Type II enzymes catalyze mono- and symmetric dimethylation. To understand the spec
Autor:
Kenny Ye, Charles C. Query, Brian Kosmyna, Matthew J. Gamble, Alyssa D. Casill, Adam J. Haimowitz
SummaryThe organization of the genome in three-dimensional space has been shown to play an important role in gene expression. Specifically, facets of genomic interaction such as topologically associated domains (TADs) have been shown to regulate tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b6af1203a09ed703c7d18b878d7ca37
https://doi.org/10.1101/2021.01.28.428713
https://doi.org/10.1101/2021.01.28.428713
Autor:
Hongshan Chen, Emmanuel S. Burgos, Charles C. Query, Varun Gupta, David Shechter, Matthew J. Gamble, Alyssa D. Casill, Maxim I. Maron, Brian Kosmyna
Protein arginine methyltransferases (PRMTs) methylate histones, splicing factors, and many other nuclear proteins. Type I enzymes (PRMT1-4,6,8) catalyze mono- (Rme1/MMA) and asymmetric (Rme2a/ADMA) dimethylation; Type II enzymes (PRMT5,9) catalyze mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ea5ac62271548bdb45d0a395e6d75f9
https://doi.org/10.1101/2020.11.18.389288
https://doi.org/10.1101/2020.11.18.389288
Autor:
Charles C. Query, Teresa V. Bowman
Publikováno v:
Blood. 135(13)
Genes encoding the RNA splicing factors SF3B1, SRSF2, and U2AF1 are subject to frequent missense mutations in clonal hematopoiesis and diverse neoplastic diseases. Most “spliceosomal” mutations affect specific hotspot residues, resulting in splic
SUMMARYAlthough expansion of snRNA genes in the human genome and sequence variation in expressed transcripts were both identified long ago, no study has comprehensively analyzed which genes are transcriptionally active. Here, we use comprehensive bio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ae3caf57b3ef07f565d9b0e4a29a3f0
https://doi.org/10.1101/2020.01.24.917260
https://doi.org/10.1101/2020.01.24.917260
Autor:
Jia Pu, Susana Rodriguez-Santiago, Andrea Yuste, Jing Wang, Varun Gupta, Qing Tang, Alberto Moldón, Charles C. Query, Yong-Zhen Xu
Publikováno v:
Genes & Development. 30:2710-2723
Mutations in the U2 snRNP component SF3B1 are prominent in myelodysplastic syndromes (MDSs) and other cancers and have been shown recently to alter branch site (BS) or 3′ splice site selection in splicing. However, the molecular mechanism of altere