Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Charles C. Ouimet"'
Publikováno v:
Journal of Comparative Neurology. 518:722-740
Histone deacetylases (HDACs) are part of a system that links epigenetic control of gene expression to a variety of environmental stimuli. Some HDACs, including HDAC4, shuttle between the cytoplasm and nucleus in response to physiological cues such as
Autor:
Orenda L. Johnson, Charles C. Ouimet
Publikováno v:
Brain Research. 1113:1-9
Dendritic spines are small protrusions that receive 90% of excitatory cortical synapses and are critically important to neural function. Each dendritic spine is supported by a dynamic actin cytoskeleton that responds to internal and external cues to
Autor:
Stephen D. Schmidt, Sam Gandy, Ralph N. Martins, Charles C. Ouimet, Lary C. Walker, William J. Lipinski, Eugene M. Laska, Jun Yao, Michael J. Callahan, Jonathan D. Smith, Michelle E. Ehrlich, Paul M. Mathews, Charles L. Bisgaier, Brian A. Turner, Carolyn A. Parker, Ralph A. Nixon, Thomas J. Montine, Peter Davies, Suzana Petanceska, David M. Holtzman
Publikováno v:
Journal of Neurochemistry. 90:1011-1018
Aging and apolipoprotein E (APOE) isoform are among the most consistent risks for the development of Alzheimer's disease (AD). Metabolic factors that modulate risk have been elusive, though oxidative reactions and their by-products have been implicat
Autor:
James A. Bibb, Jane R. Taylor, Eric J. Nestler, Seth D. Norrholm, Paul Greengard, Charles C. Ouimet
Publikováno v:
Neuroscience. 116:19-22
Repeated exposure to cocaine produces an enduring increase in dendritic spine density in adult rat nucleus accumbens. It has been shown previously that chronic cocaine administration increases the expression of cyclin-dependent kinase-5 in this brain
Publikováno v:
Journal of Neurobiology. 51:115-128
In the mammalian brain, adult neurogenesis has been found to occur primarily in the subventricular zone (SVZ) and dentate gyrus of the hippocampus (DG) and to be influenced by both exogenous and endogenous factors. In the present study, we examined t
Autor:
Patrick B. Allen, Paul Greengard, Jian Feng, Thomas A. Houpt, Carrie A. Stafstrom-Davis, Charles C. Ouimet
Publikováno v:
Learning & Memory. 8:272-278
Plasticity in dendritic spines may underlie learning and memory. Spinophilin, a protein enriched in dendritic spines, has the properties of a scaffolding protein and is believed to regulate actin cytoskeletal dynamics affecting dendritic spine morpho
Autor:
Jane R. Taylor, Akinori Nishi, James A. Bibb, Charles C. Ouimet, Zachary K. Sagawa, Angus C. Nairn, Eric J. Nestler, Per Svenningsson, Gretchen L. Snyder, Zhen Yan, Jingshan Chen, Paul Greengard
Publikováno v:
Nature. 410:376-380
Cocaine enhances dopamine-mediated neurotransmission by blocking dopamine re-uptake at axon terminals. Most dopamine-containing nerve terminals innervate medium spiny neurons in the striatum of the brain. Cocaine addiction is thought to stem, in part
Autor:
Seth D. Norrholm, Charles C. Ouimet
Publikováno v:
Synapse. 42:151-163
Olfactory bulbectomy, neonatal clomipramine administration, and maternal deprivation have been employed as animal models of depression. Each model is unique with respect to the experimental manipulations required to produce "depressive" signs, expres
Autor:
Kazuhito Tomizawa, Paul Greengard, Adriana Ferreira, Jason Liauw, Zhen Yan, Patrick B. Allen, Min Zhuo, Jian Feng, Charles C. Ouimet
Publikováno v:
Proceedings of the National Academy of Sciences. 97:9287-9292
Spinophilin, a protein that interacts with actin and protein phosphatase-1, is highly enriched in dendritic spines. Here, through the use of spinophilin knockout mice, we provide evidence that spinophilin modulates both glutamatergic synaptic transmi
Autor:
Patrick B. Allen, Zhen Yan, Linda C. Hsieh-Wilson, Charles C. Ouimet, Paul Greengard, Jian Feng
Publikováno v:
Biochemical Society Transactions. 27:543-546
Communication between nerve cells is mediated by both electrical and chemical signals. Chemical neurotransmission can be further categorized into fast and slow components. Fast acting neurotransmitters directly influence neuronal electrical excitabil