Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Charles C. J. Loh"'
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Halogen bonding (HB) catalysis is rapidly gaining momentum, however, cases of XB activation for challenging bonds formation are rare. Here, the authors show a robust XB catalyzed 2-deoxyglycosylation with broad scope and featuring a quantum tunneling
Externí odkaz:
https://doaj.org/article/97b970db1d374094a4263f74f9fda1f1
Autor:
Chunfa Xu, Charles C. J. Loh
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Non-covalent glycosyl donor activation often requires high organocatalyst loadings. Here, the authors demonstrate that strain-release glycosylations can take place at very low thiourea catalyst loadings. In addition, the authors developed a one-pot m
Externí odkaz:
https://doaj.org/article/bf2fd9e1731b4649aed90bc2f3e92b75
Autor:
Charles C. J. Loh
Publikováno v:
Nature Reviews Chemistry. 5:792-815
Non-covalent interactions (NCIs) are a vital component of biological bond-forming events, and have found important applications in multiple branches of chemistry. In recent years, the biomimetic exploitation of NCIs in challenging glycosidic bond for
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications
The development of noncovalent halogen bonding (XB) catalysis is rapidly gaining traction, as isolated reports documented better performance than the well-established hydrogen bonding thiourea catalysis. However, convincing cases allowing XB activati
Autor:
V. U. Bhaskara Rao, Caiming Wang, Daniel P. Demarque, Corentin Grassin, Felix Otte, Christian Merten, Carsten Strohmann, Charles C. J. Loh
Publikováno v:
Nature chemistry.
Site-selective functionalization is a core synthetic strategy that has broad implications in organic synthesis. Particularly, exploiting chiral catalysis to control site selectivity in complex carbohydrate functionalizations has emerged as a leading
Autor:
Chunfa Xu, Charles C. J. Loh
Publikováno v:
Journal of the American Chemical Society. 141(13)
Halogen bonding (XB) has recently emerged as a promising noncovalent activation mode that can be employed in catalysis. However, methodologies utilizing XB remain rare, and the hydrogen-bonding (HB) catalysis congeners are more widespread in comparis
Publikováno v:
Angewandte Chemie International Edition. 55:4600-4604
While the utility of vinylogous enolates is well established in the setting of vinylogous aldol, Mannich, and Michael chemistries, literature reports concerning γ-reactivity are scarce for other reaction classes. Presented herein is an unprecedented
Autor:
Charles C. J. Loh, Dieter Enders, Server Uzungelis, Pankaj Chauhan, Suruchi Mahajan, Gerhard Raabe
Publikováno v:
Synthesis
Synthesis 47(7), 1024-1031 (2015). doi:10.1055/s-0034-1379943
Synthesis 47(7), 1024-1031 (2015). doi:10.1055/s-0034-1379943
A highly diastereo- and enantioselective domino Michael/Henry reaction of 1-acetylindolin-3-ones with o-formyl-(E)-β-nitrostyrenes catalyzed by low loading of a quinine-derived amine-squaramide provides the corresponding indolin-3-one derivatives be
Autor:
Charles C. J. Loh, Amalia I. Poblador-Bahamonde, Ivan Franzoni, Shabnam K. Yazdi, Robert Webster, Mark Lautens, Ken-Loon Choo, Andy Yen, Patrick T. Franke
Publikováno v:
Angewandte Chemie: International Edition, Vol. 56, No 22 (2017) pp. 6307-6311
Herein we describe a rhodium-catalyzed enantioselective isomerization of meso-oxabicyclic alkenes to 1,2-naphthalene oxides. These potentially useful building blocks can be accessed in moderate to excellent yields with impressive enantioselectivities
Publikováno v:
Advanced Synthesis & Catalysis. 356:3181-3186
An expedient asymmetric synthesis of polyfunctionalized indanols bearing four contiguous stereogenic centres, including a quarternary centre through the use of sub-mol% amounts of a squara- mide catalyst within minutes is presented. A gram- scale exp