Zobrazeno 1 - 10
of 212
pro vyhledávání: '"Charles C. Caldwell"'
Autor:
Adam D. Price, Ellen R. Becker, Evan L. Barrios, Monty B. Mazer, Patrick W. McGonagill, Christian B. Bergmann, Michael D. Goodman, Robert W. Gould, Mahil Rao, Valerie E. Polcz, Tamara A. Kucaba, Andrew H. Walton, Sydney Miles, Julie Xu, Muxuan Liang, Tyler J. Loftus, Philip A. Efron, Kenneth E. Remy, Scott C. Brakenridge, Vladimir P. Badovinac, Thomas S. Griffith, Lyle L. Moldawer, Richard S. Hotchkiss, Charles C. Caldwell
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionSepsis is a complex clinical syndrome characterized by a heterogenous host immune response. Historically, static protein and transcriptomic metrics have been employed to describe the underlying biology. Here, we tested the hypothesis that
Externí odkaz:
https://doaj.org/article/0d40c4cf70d04695a92503d2f0ae310b
Autor:
Christian B. Bergmann, Bruce D. Hammock, Debin Wan, Falk Gogolla, Holly Goetzman, Charles C. Caldwell, Dorothy M. Supp
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Oxylipins modulate the behavior of immune cells in inflammation. Soluble epoxide hydrolase (sEH) converts anti-inflammatory epoxyeicosatrienoic acid (EET) to dihydroxyeicosatrienoic acid (DHET). An sEH-inhibitor, TPPU, has been demonstrated
Externí odkaz:
https://doaj.org/article/6300e06abb654c439c3679971309bcfc
Autor:
Nadine Beckmann, Amanda M. Pugh, Nicholas J. Auteri, Michael J. Edwards, Erich Gulbins, Charles C. Caldwell
Publikováno v:
Cellular Physiology and Biochemistry, Vol 545, Iss 5, Pp 1054-1067 (2020)
Externí odkaz:
https://doaj.org/article/0eafc35215544281b4a3d0f0b417be23
Autor:
Monty B. Mazer, MD, Isaiah R. Turnbull, MD, PhD, Sydney Miles, BS, Teresa M. Blood, BS, Brooke Sadler, PhD, Annie Hess, MD, Mitchell D. Botney, MD, Robert S. Martin, MD, James P. Bosanquet, MD, David A. Striker, MD, Nitin S. Anand, MD, Michel Morre, DVM, MSc, Charles C. Caldwell, PhD, Scott C. Brakenridge, MD, MSCS, Lyle L. Moldawer, PhD, Jorge A. Di Paola, MD, Richard S. Hotchkiss, MD, Kenneth E. Remy, MD, MHSc, MSCI
Publikováno v:
Critical Care Explorations, Vol 3, Iss 7, p e0500 (2021)
BACKGROUND:. Immunotherapy treatment for coronavirus disease 2019 combined with antiviral therapy and supportive care remains under intense investigation. However, the capacity to distinguish patients who would benefit from immunosuppressive or immun
Externí odkaz:
https://doaj.org/article/1fac6631ade54835940d3bacdc623ba2
Autor:
Brent T. Xia, Nadine Beckmann, Leah K. Winer, Amanda M. Pugh, Timothy A. Pritts, Vanessa Nomellini, Erich Gulbins, Charles C. Caldwell
Publikováno v:
Cellular Physiology and Biochemistry, Vol 52, Iss 3, Pp 565-579 (2019)
Externí odkaz:
https://doaj.org/article/196bbfe791704a12b8a569d4dac041e8
Autor:
Monty B. Mazer, MD, Ethan Davitt, , BS, Isaiah R. Turnbull, MD, PhD, Charles C. Caldwell, PhD, Scott C. Brakenridge, MD, Kenneth E. Remy, MD, MHSc, MSCI, Richard S. Hotchkiss, MD
Publikováno v:
Critical Care Explorations, Vol 3, Iss 4, p e0378 (2021)
Objectives:. Corticosteroid therapy has become standard of care therapy for hospitalized patients infected with the severe acute respiratory syndrome coronavirus-2 global pandemic-causing virus. Whereas systemic inflammation is a notably important fe
Externí odkaz:
https://doaj.org/article/42efcbf7cf9849c7bd6b3948ba35d9b8
Autor:
Christian B. Bergmann, Nadine Beckmann, Christen E. Salyer, Marc Hanschen, Peter A. Crisologo, Charles C. Caldwell
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
In sepsis and trauma, pathogens and injured tissue provoke a systemic inflammatory reaction which can lead to overwhelming inflammation. Concurrent with the innate hyperinflammatory response is adaptive immune suppression that can become chronic. A c
Externí odkaz:
https://doaj.org/article/04432042b4e9420c86c8a2fa6bd8f092
Autor:
Kenneth E. Remy, Monty Mazer, David A. Striker, Ali H. Ellebedy, Andrew H. Walton, Jacqueline Unsinger, Teresa M. Blood, Philip A. Mudd, Daehan J. Yi, Daniel A. Mannion, Dale F. Osborne, R. Scott Martin, Nitin J. Anand, James P. Bosanquet, Jane Blood, Anne M. Drewry, Charles C. Caldwell, Isaiah R. Turnbull, Scott C. Brakenridge, Lyle L. Moldwawer, Richard S. Hotchkiss
Publikováno v:
JCI Insight, Vol 5, Iss 17 (2021)
COVID-19–associated morbidity and mortality have been attributed to a pathologic host response. Two divergent hypotheses have been proposed: hyperinflammatory cytokine storm; and failure of host protective immunity that results in unrestrained vira
Externí odkaz:
https://doaj.org/article/e8dd85cce0b24e16aeb05e045c745304
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
While mortality after acute sepsis has decreased, the long-term recovery for survivors is still poor, particularly those developing persistent inflammation, immunosuppression, and catabolism syndrome (PICS). While previously thought that activated ne
Externí odkaz:
https://doaj.org/article/551fc7157120431cbe360fd2759ec565
Autor:
Nadine Beckmann, Franziska Huber, Marc Hanschen, Barbara St. Pierre Schneider, Vanessa Nomellini, Charles C. Caldwell
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Infection is a common and severe complication of burn injury: Sepsis accounts for 47% of postburn mortality. Burn-induced T cell suppression likely contributes to the increased infection susceptibility in burn patients. However, little is known about
Externí odkaz:
https://doaj.org/article/19aa9d6fee704a5b9bac001411f9e91c