Zobrazeno 1 - 10
of 201
pro vyhledávání: '"Charles C Hong"'
Autor:
Fahad Alkhalfan, Alex Gyftopoulos, Yi-Ju Chen, Charles H Williams, James A Perry, Charles C Hong
Publikováno v:
PLoS ONE, Vol 17, Iss 8, p e0273217 (2022)
ObjectivesTo utilize the UK Biobank to identify genetic variants associated with the ICD10 (International Classification of Diseases10)-based diagnosis of cerebrovascular disease (CeVD).BackgroundCerebrovascular disease occurs because of a complex in
Externí odkaz:
https://doaj.org/article/aec1dca5fa254a0a84f4a3247549b3fc
Autor:
Tamara Ashvetiya, Sherry X Fan, Yi-Ju Chen, Charles H Williams, Jeffery R O'Connell, James A Perry, Charles C Hong
Publikováno v:
PLoS ONE, Vol 16, Iss 9, p e0247287 (2021)
BackgroundThoracic aortic aneurysm (TAA) and abdominal aortic aneurysm (AAA) are known to have a strong genetic component.Methods and resultsIn a genome-wide association study (GWAS) using the UK Biobank, we analyzed the genomes of 1,363 individuals
Externí odkaz:
https://doaj.org/article/a0505206eb8a4cd58caac22450681d78
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0248602 (2021)
BackgroundSARS-CoV-2 is a rapidly spreading coronavirus responsible for the Covid-19 pandemic, which is characterized by severe respiratory infection. Many factors have been identified as risk factors for SARS-CoV-2, with much early attention being p
Externí odkaz:
https://doaj.org/article/8969244282a94b80a9a9caeaff2ec1ce
Publikováno v:
BMC Research Notes, Vol 17, Iss 1, Pp 1-8 (2024)
Abstract Objective Inhibition and knockdown of GPR68 negatively affects glioblastoma cell survival in vitro by inducing ferroptosis. Herein, we aimed to demonstrate that inhibition of GPR68 reduces the survival of glioblastoma cells in vivo using two
Externí odkaz:
https://doaj.org/article/94e7ff82a9684f14a93f9d23e3e06a17
Autor:
Jennifer L Herington, Daniel R Swale, Naoko Brown, Elaine L Shelton, Hyehun Choi, Charles H Williams, Charles C Hong, Bibhash C Paria, Jerod S Denton, Jeff Reese
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0143243 (2015)
The uterine myometrium (UT-myo) is a therapeutic target for preterm labor, labor induction, and postpartum hemorrhage. Stimulation of intracellular Ca2+-release in UT-myo cells by oxytocin is a final pathway controlling myometrial contractions. The g
Externí odkaz:
https://doaj.org/article/f0f2083e05c54991a5f8cc8c6e99d788
Autor:
Megha Talati, James West, Rinat Zaynagetdinov, Charles C Hong, Wei Han, Tom Blackwell, Linda Robinson, Timothy S Blackwell, Kirk Lane
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94119 (2014)
Pulmonary arterial hypertension (PAH) is a disease of progressively increasing pulmonary vascular resistance, associated with mutations of the type 2 receptor for the BMP pathway, BMPR2. The canonical signaling pathway for BMPR2 is through the SMAD f
Externí odkaz:
https://doaj.org/article/08156025a98f4e33bd178f47388b0811
Autor:
Charles H. Williams, Leif R. Neitzel, Jessica Cornell, Samantha Rea, Ian Mills, Maya S. Silver, Jovanni D. Ahmad, Konstantin G. Birukov, Anna Birukova, Henry Brem, Betty Tyler, Eli E. Bar, Charles C. Hong
Publikováno v:
Experimental Hematology & Oncology, Vol 13, Iss 1, Pp 1-18 (2024)
Abstract Background Glioblastoma multiforme (GBM) stands as a formidable challenge in oncology because of its aggressive nature and severely limited treatment options. Despite decades of research, the survival rates for GBM remain effectively stagnan
Externí odkaz:
https://doaj.org/article/f7b2aed27b4f4e79988cd025a47bae74
Autor:
Elaine L Shelton, Cristi L Galindo, Charles H Williams, Elise Pfaltzgraff, Charles C Hong, David M Bader
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69712 (2013)
Mesothelia, which cover all coelomic organs and body cavities in vertebrates, perform diverse functions in embryonic and adult life. Yet, mesothelia are traditionally viewed as simple, uniform epithelia. Here we demonstrate distinct differences betwe
Externí odkaz:
https://doaj.org/article/ccc9d331ce264c8293c9b5dc45302c08
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61256 (2013)
Bone morphogenetic proteins (BMPs) are highly conserved morphogens that are essential for normal development. BMP-2 is highly expressed in the majority of non-small cell lung carcinomas (NSCLC) but not in normal lung tissue or benign lung tumors. The
Externí odkaz:
https://doaj.org/article/24435ea8697b4e59afe06ed99d8d8444
Autor:
Philip Owens, Hannah Polikowsky, Michael W Pickup, Agnieszka E Gorska, Bojana Jovanovic, Aubie K Shaw, Sergey V Novitskiy, Charles C Hong, Harold L Moses
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e67533 (2013)
Bone Morphogenetic Proteins (BMPs) are secreted cytokines that are part of the Transforming Growth Factor β (TGFβ) superfamily. BMPs have been shown to be highly expressed in human breast cancers, and loss of BMP signaling in mammary carcinomas has
Externí odkaz:
https://doaj.org/article/1022ab551d4145f38daba71161377eec