Výsledky vyhledávání - "Charles C, Chu"

Akademický článek

Binding of CLL Subset 4 B Cell Receptor Immunoglobulins to Viable Human Memory B Lymphocytes Requires a Distinctive IGKV Somatic Mutation

Autor: Rosa Catera, Yun Liu, Chao Gao, Xiao-Jie Yan, Amanda Magli, Steven L. Allen, Jonathan E. Kolitz, Kanti R. Rai, Charles C. Chu, Ten Feizi, Kostas Stamatopoulos, Nicholas Chiorazzi

Publikováno v: Molecular Medicine, Vol 23, Iss 1, Pp 1-12 (2017)

Abstract Amino acid replacement mutations in certain chronic lymphocytic leukemia (CLL) stereotyped B cell receptor (BCR) immunoglobulins (IGs) at defined positions within antigen-binding sites strongly imply antigen selection. Prime examples of this

Externí odkaz: https://doaj.org/article/9e9c41d121d1407f8fb9aa6e622fb796

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Figure S1 from Chronic Lymphocytic Leukemia with Mutated IGHV4-34 Receptors: Shared and Distinct Immunogenetic Features and Clinical Outcomes

Autor: Kostas Stamatopoulos, Paolo Ghia, Richard Rosenquist, Anastasia Hadzidimitriou, Frederic Davi, Chrysoula Belessi, Nikos Darzentas, Ioanna Chouvarda, Stephan Stilgenbauer, Diane F. Jelinek, Gianluca Gaidano, David Oscier, Nikos Maglaveras, Nicholas Chiorazzi, Elias Campo, Michael Hallek, Sarka Pospisilova, Anton W. Langerak, Hartmut Döhner, Carsten Niemann, Marco Montillo, Livio Trentin, Darko Antic, Ioannis Vlahavas, Achilles Anagnostopoulos, Gunnar Juliusson, Panagiotis Panagiotidis, Marie-Paule Lefranc, Véronique Giudicelli, Charles C. Chu, Karin E. Smedby, Larry Mansouri, Lone Bredo Pedersen, Christiane Pott, Jasmin Bahlo, Monica Facco, Maria Chatzouli, Dirk Kienle, Mark Catherwood, Teodora Karan-Djurasevic, Tatiana Tzenou, Silvio Veronese, Andrey Sudarikov, Niki Stavroyianni, Lydia Scarfo, Fie Juhl Vojdeman, Yorick Sandberg, Alba Navarro, Zadie Davis, Davide Rossi, Myriam Boudjogra, Karla Plevova, Tait Shanafelt, Xiao-Jie Yan, Eugen Tausch, Stavroula Ntoufa, Eva Minga, Lesley-Ann Sutton, Andreas Agathangelidis, Ioannis Kavakiotis, Panagiotis Baliakas, Aliki Xochelli

Distribution of IGHV4-34 CLL according to IGHV mutational status and subset membership.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c3d3f916dc7ca72c06758ce21dd25bc
https://doi.org/10.1158/1078-0432.22466067

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Data from Chronic Lymphocytic Leukemia with Mutated IGHV4-34 Receptors: Shared and Distinct Immunogenetic Features and Clinical Outcomes

Purpose: We sought to investigate whether B cell receptor immunoglobulin (BcR IG) stereotypy is associated with particular clinicobiological features among chronic lymphocytic leukemia (CLL) patients expressing mutated BcR IG (M-CLL) encoded by the I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::141c24fb06d5c3e1a7289bcc228ffa82
https://doi.org/10.1158/1078-0432.c.6526230

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Table S1 from Chronic Lymphocytic Leukemia with Mutated IGHV4-34 Receptors: Shared and Distinct Immunogenetic Features and Clinical Outcomes

Univariable and multivariable analysis for TTFT within M-CLL.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1fb7f202357cc43ba7c3642e12d9a09
https://doi.org/10.1158/1078-0432.22466046

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Akademický článek

Complement Activation in the Treatment of B-Cell Malignancies

Autor: Clive S. Zent, Jonathan J. Pinney, Charles C. Chu, Michael R. Elliott

Publikováno v: Antibodies, Vol 9, Iss 4, p 68 (2020)

Unconjugated monoclonal antibodies (mAb) have revolutionized the treatment of B-cell malignancies. These targeted drugs can activate innate immune cytotoxicity for therapeutic benefit. mAb activation of the complement cascade results in complement-de

Externí odkaz: https://doaj.org/article/ad5a0eb04bab4bc094fe0a6e5fe658c1

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Akademický článek

No improvement in long-term survival over time for chronic lymphocytic leukemia patients in stereotyped subsets #1 and #2 treated with chemo(immuno)therapy

Publikováno v: Haematologica, Vol 103, Iss 4 (2018)

Externí odkaz: https://doaj.org/article/66a40c8943b2491c920a9d95992f286d

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Moderate dose alcohol protects against serum amyloid protein A1‐induced endothelial dysfunction via both notch‐dependent and notch‐independent pathways

Autor: Eileen M. Redmond, Weimin Liu, Charles C. Chu, Paul A. Cahill, Naresh Kumar Rajendran

Publikováno v: Alcohol Clin Exp Res

Background Arterial endothelium plays a critical role in maintaining vessel homeostasis and preventing atherosclerotic cardiovascular disease (CVD). Low-to-moderate alcohol (EtOH) consumption is associated with reduced atherosclerosis and stimulates

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd59401db08df957f07e0b73fb0b17e8
https://doi.org/10.1111/acer.14706

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Akademický článek

The Number of Overlapping AID Hotspots in Germline IGHV Genes Is Inversely Correlated with Mutation Frequency in Chronic Lymphocytic Leukemia.

Autor: Chaohui Yuan, Charles C Chu, Xiao-Jie Yan, Davide Bagnara, Nicholas Chiorazzi, Thomas MacCarthy

Publikováno v: PLoS ONE, Vol 12, Iss 1, p e0167602 (2017)

The targeting of mutations by Activation-Induced Deaminase (AID) is a key step in generating antibody diversity at the Immunoglobulin (Ig) loci but is also implicated in B-cell malignancies such as chronic lymphocytic leukemia (CLL). AID has previous

Externí odkaz: https://doaj.org/article/86c405b3268d495a9e7aaa06738368d2

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