Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Charles Burghardt"'
Autor:
Shaoqing Chen, Paul Gillespie, Sung-Sau So, Steven Gregory Mischke, David Robert Bolin, Nam T. Le, Frank Mennona, Mushtaq Ahmad, Karin Conde-Knape, Charles Burghardt, Hong Wang, Shahid Tannu, Yimin Qian, Jarema Peter Kochan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:6264-6269
Through high throughput screening and subsequent hit identification and optimization, we synthesized a series of 1-arylcarbonyl-6,7-dimethoxyisoquinoline derivatives as the first reported potent and reversible GFAT inhibitors. SAR studies of this cla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1ce41d6fc54e9d94c3232db8c5a857f
https://doi.org/10.1016/j.bmcl.2011.09.009
https://doi.org/10.1016/j.bmcl.2011.09.009
Autor:
Jarema Peter Kochan, John F. Breininger, Jonathan B. Schaefer, Michael Krouse, Randy J. Seeley, Stephen C. Woods, Paul Burn, Denis G. Baskin, L. Arthur Campfield, Charles Burghardt, Michael W. Schwartz, Zoe Jonak, Daniel Porte
Publikováno v:
Journal of Histochemistry & Cytochemistry. 47:353-362
Reduced leptin (Ob protein) signaling is proposed to be a stimulus for the activation of neuropeptide Y (NPY) gene activity and increased expression of mRNA for the long form of the leptin receptor (Ob-Rb) in the hypothalamic arcuate nucleus. To dete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23194f831c80a3f68cf0001b3e2574e9
https://doi.org/10.1177/002215549904700309
https://doi.org/10.1177/002215549904700309
Autor:
Ting Chen, Perla Nunes, Zhicheng Zhao, David S. Waugh, Alasdair M. Gilfillan, Jarema Peter Kochan, Charles Burghardt, Barbara Repetto, Richard Anthony Chizzonite, Waleed Danho, Mike Visnick, Mitali Basu, Elizabeth Dharm, Robert E. Carroll, Christine E. Pullar
Publikováno v:
Journal of Biological Chemistry. 271:25308-25315
To examine the characteristics of the interaction of the FcϵRIγ ITAM with the SH2 domains of p72syk, the binding of an 125I-labeled dual phosphorylated FcϵRIγ ITAM-based peptide to the p72syk SH2 domains was monitored utilizing a novel scintillat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f176df2cdc6914e6f9e60a4746d6b30
https://doi.org/10.1074/jbc.271.41.25308
https://doi.org/10.1074/jbc.271.41.25308
Autor:
Charles Burghardt, David R. Janero
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 526:11-24
Solid-phase extraction methods using pre-packed silica cartridges and various elution solvents have been developed and evaluated as chromatographic means to enrich biological lipid extracts for platelet-activating factor (PAF). The optimized procedur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0d3a304b876027630da67ede51e81d6
https://doi.org/10.1016/s0378-4347(00)82479-2
https://doi.org/10.1016/s0378-4347(00)82479-2
Publikováno v:
Journal of Human Stress. 8:19-27
In our laboratory we have been studying the alterations in platelet physiology before, during and after emotional arousal. The findings indicate a clear relationship between affective states and the ability of platelets to respond to stimuli in vitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b4095c5423b8db3e97b59acb1f6389d
https://doi.org/10.1080/0097840x.1982.9936843
https://doi.org/10.1080/0097840x.1982.9936843
Autor:
L. R. Klevans, Barbara Burghardt, Fahrenholtz K, Zawoiski S, Charles Burghardt, Thomas F. Mowles, Hirkaler G, Jefferson Wright Tilley, Leinweber Fj, Young R
Publikováno v:
Journal of Medicinal Chemistry. 31:466-472
A series of N-[(heteroaryl)alkyl]pyrido[2,1-b]quinazolines were evaluated for their ability to inhibit the binding of radiolabeled platelet activating factor (PAF) to its receptor on dog platelets. The most potent compounds in this series were found
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::983ff92cbb4fe98ff7efd6f11c714240
https://doi.org/10.1021/jm00397a034
https://doi.org/10.1021/jm00397a034
Autor:
David R. Janero, Charles Burghardt
Publikováno v:
Journal of Cellular Physiology. 140:150-160
Long-chain nonesterified fatty acid (NEFA) accumulation in the heart muscle cell (myocyte) and NEFA release to the extracellular milieu are considered contributors to the pathogenesis of myocardial injury in a number of cardiovascular disease states.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea249477eb2b7b50ac9706837056dce8
https://doi.org/10.1002/jcp.1041400118
https://doi.org/10.1002/jcp.1041400118
Autor:
Charles Burghardt, Annette M. Charnecki, Herbert Sheppard, Barbara Burghardt, Thomas F. Mowles
Publikováno v:
Life Sciences. 22:2103-2112
Dopamine can act directly on pituitary cells to inhibit prolactin release. This action can be blocked by dopamine receptor blocking drugs such as haloperidol, sulpiride and other neuroleptic agents. Comparison of the properties of the mammotroph dopa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99942765cca82c64084e8ff3621d983b
https://doi.org/10.1016/0024-3205(78)90454-x
https://doi.org/10.1016/0024-3205(78)90454-x
Publikováno v:
Journal of Pharmacological Methods. 20:237-253
High-affinity, stereoselective, and ligand-selective specific binding of 3H-labeled platelet-activating factor (PAF) to its receptor on the dog platelet is reproducible over wide mass and concentration ranges of [3H]PAF. The [3H]PAF specific binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3db92ed310cf2ff195091133f2822e62
https://doi.org/10.1016/0160-5402(88)90066-6
https://doi.org/10.1016/0160-5402(88)90066-6
Autor:
Charles Burghardt, Herbert Sheppard
Publikováno v:
Biochemical Pharmacology. 22:427-429
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8959d376a4338ef2bc04d8b3c9c387a6
https://doi.org/10.1016/0006-2952(73)90423-1
https://doi.org/10.1016/0006-2952(73)90423-1