Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Charles Blaha"'
Autor:
Eun Jung Kim, Caressa Chen, Rebecca Gologorsky, Ana Santandreu, Alonso Torres, Nathan Wright, Mark S. Goodin, Jarrett Moyer, Benjamin W. Chui, Charles Blaha, Paul Brakeman, Shant Vartanian, Qizhi Tang, H. David Humes, William H. Fissell, Shuvo Roy
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract The definitive treatment for end-stage renal disease is kidney transplantation, which remains limited by organ availability and post-transplant complications. Alternatively, an implantable bioartificial kidney could address both problems whi
Externí odkaz:
https://doaj.org/article/0d211e11b47246acb10abcd7f2c4c868
Characterization of human islet function in a convection‐driven intravascular bioartificial pancreas
Autor:
Ana G. Santandreu, Parsa Taheri‐Tehrani, Benjamin Feinberg, Alonso Torres, Charles Blaha, Rebecca Shaheen, Jarrett Moyer, Nathan Wright, Gregory L. Szot, William H. Fissell, Shant Vartanian, Andrew Posselt, Shuvo Roy
Publikováno v:
Bioengineering & Translational Medicine, Vol 8, Iss 2, Pp n/a-n/a (2023)
Abstract Clinical islet transplantation for treatment of type 1 diabetes (T1D) is limited by the shortage of pancreas donors and need for lifelong immunosuppressive therapy. A convection‐driven intravascular bioartificial pancreas (iBAP) based on h
Externí odkaz:
https://doaj.org/article/0675fe5c6d8140268bd6b9cb8205c8bc
Autor:
Jarrett Moyer, Mark W. Wilson, Thomas A. Sorrentino, Ana Santandreu, Caressa Chen, Dean Hu, Amy Kerdok, Edward Porock, Nathan Wright, Jimmy Ly, Charles Blaha, Lynda A. Frassetto, William H. Fissell, Shant M. Vartanian, Shuvo Roy
Publikováno v:
Toxins, Vol 15, Iss 9, p 547 (2023)
Reliable models of renal failure in large animals are critical to the successful translation of the next generation of renal replacement therapies (RRT) into humans. While models exist for the induction of renal failure, none are optimized for the im
Externí odkaz:
https://doaj.org/article/10dc292520934108adbb50cde887060e
Publikováno v:
Fluids, Vol 7, Iss 7, p 222 (2022)
We present a multi-scale mathematical model and a novel numerical solver to study blood plasma flow and oxygen concentration in a prototype model of an implantable Bioartificial Pancreas (iBAP) that operates under arteriovenous pressure differential
Externí odkaz:
https://doaj.org/article/fa08cd95cecb4d85acd3a24463a1eddc
Characterization of human islet function in a convection‐driven intravascular bioartificial pancreas
Autor:
Ana G. Santandreu, Parsa Taheri‐Tehrani, Benjamin Feinberg, Alonso Torres, Charles Blaha, Rebecca Shaheen, Jarrett Moyer, Nathan Wright, Gregory L. Szot, William H. Fissell, Shant Vartanian, Andrew Posselt, Shuvo Roy
Publikováno v:
Bioengineering & translational medicine, vol 8, iss 2
Clinical islet transplantation for treatment of type 1 diabetes (T1D) is limited by the shortage of pancreas donors and need for lifelong immunosuppressive therapy. A convection-driven intravascular bioartificial pancreas (iBAP) based on highly perme
Autor:
David G. Blauvelt, Nicholas Higgins, Bianca De, Mark S. Goodin, Nathan Wright, Charles Blaha, Jarrett Moyer, Benjamin Chui, Francisco Baltazar, Peter Oishi, Shuvo Roy
Extremely preterm infants have poor clinical outcomes due to lung immaturity. An artificial placenta could provide extracorporeal gas exchange, allowing normal lung growth outside of the uterus, thus improving outcomes. However, current devices in de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f1260185306b12716b1e32aca72753b
https://doi.org/10.1101/2022.08.23.505025
https://doi.org/10.1101/2022.08.23.505025
Autor:
David A. Maginnis, Charles Blaha, William H. Fissell, Benjamin W. Chui, Nathan Wright, Tariq M. Haniff, Jimmy Ly, Shuvo Roy
Publikováno v:
Journal of Microelectromechanical Systems. 29:762-768
Silicon nanoporous membranes provide the fundamental underlying technology for the development of an implantable bio-artificial kidney. These membranes, which are comprised of micromachined slit-pores that are nominally 10 nm wide, allow for high-eff
Autor:
Steven Kim, Benjamin Feinberg, Rishi Kant, Benjamin Chui, Ken Goldman, Jaehyun Park, Willieford Moses, Charles Blaha, Zohora Iqbal, Clarence Chow, Nathan Wright, William H Fissell, Andrew Zydney, Shuvo Roy
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159526 (2016)
Hemodialysis using hollow-fiber membranes provides life-sustaining treatment for nearly 2 million patients worldwide with end stage renal disease (ESRD). However, patients on hemodialysis have worse long-term outcomes compared to kidney transplant or
Externí odkaz:
https://doaj.org/article/08c7dfe9101e486091b9624dd9065613
Autor:
Robert R. Flavell, Niranjan Meher, Michael J. Evans, Suchi Dhrona, Xiao Huang, Kyounghee Seo, Anil Parsram Bidkar, Tomoko Ozawa, David R. Raleigh, Henry F. VanBrocklin, Young-wook Jun, Ryan Tang, David M. Wilson, Charles Blaha, Sinan Wang, Miko Fogarty, Tejal A. Desai
Publikováno v:
ACS applied materialsinterfaces. 13(46)
Boron neutron capture therapy (BNCT) is an encouraging therapeutic modality for cancer treatment. Prostate-specific membrane antigen (PSMA) is a cell membrane protein that is abundantly overexpressed in prostate cancer and can be targeted with radiol
Autor:
Rebecca Shaheen, Matthias Hebrok, Phichitpol P. Carnese, Pujita Munnangi, William H. Fissell, Ana Santandreu, Rebecca C. Gologorsky, Charles Blaha, Alonso Torres, Gopika G. Nair, Shuvo Roy, Gregory L. Szot, Rachel E. Gurlin
Publikováno v:
Journal of biomedical materials research. Part AREFERENCES. 109(12)
Type 1 diabetic patients with severe hypoglycemia unawareness have benefitted from cellular therapies, such as pancreas or islet transplantation; however, donor shortage and the need for immunosuppression limits widespread clinical application. We pr