Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Charles B. Wright"'
Autor:
Bradley D. Gelfand, Charles B. Wright, Younghee Kim, Tetsuhiro Yasuma, Reo Yasuma, Shengjian Li, Benjamin J. Fowler, Ana Bastos-Carvalho, Nagaraj Kerur, Annette Uittenbogaard, Youn Seon Han, Dingyuan Lou, Mark E. Kleinman, W. Hayes McDonald, Gabriel Núñez, Philippe Georgel, Joshua L. Dunaief, Jayakrishna Ambati
Publikováno v:
Cell Reports, Vol 11, Iss 11, Pp 1686-1693 (2015)
Excess iron induces tissue damage and is implicated in age-related macular degeneration (AMD). Iron toxicity is widely attributed to hydroxyl radical formation through Fenton’s reaction. We report that excess iron, but not other Fenton catalytic me
Externí odkaz:
https://doaj.org/article/978a1cd998d14ea7902ee02655f15e7f
Autor:
Charles B. Wright, Steven Becker
Publikováno v:
J Ocul Pharmacol Ther
Purpose: This update will highlight a few of the projects funded by the National Eye Institute (NEI) Audacious Goals Initiative for Regenerative Medicine (AGI) and show their potential to advance regenerative medicine strategies and increase our unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb8fae0992b79de8ee493e823d10c12b
https://europepmc.org/articles/PMC8060710/
https://europepmc.org/articles/PMC8060710/
Publikováno v:
Translational Vision Science & Technology
Translational vision science & technology, vol 9, iss 7
Translational vision science & technology, vol 9, iss 7
Author(s): Wright, Charles; Mazzucco, Anna E; Becker, Steven M; Sieving, Paul A; Tumminia, Santa J | Abstract: PurposeTo review past and current National Eye Institute (NEI)-supported age-related macular degeneration (AMD) activities and initiatives
Autor:
Bradley D. Gelfand, Nagaraj Kerur, Yosuke Nagasaka, Ambati Balamurali K, Shinichi Fukuda, Jayakrishna Ambati, Charles B. Wright, Benjamin J. Fowler, Bo Chang, Tetsuhiro Yasuma, Siddharth Narendran, Izuho Hatada, Reo Yasuma, Philippe Georgel, Ana Bastos-Carvalho, Felipe Pereira, Romulo Albuquerque, Younghee Kim, Shuichiro Hirahara, Ivana Apicella, Hironori Uehara, Ryan D. Makin
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance DICER1 processes micro-RNAs into their bioactive forms and metabolizes RNAs from short interspersed nuclear element genetic repeats, principally Alu RNAs in humans. DICER1 deficiency is implicated in retinal pigmented epithelium (RPE) de
Autor:
Nathaniel F Henneman, Jana T Sellers, Robin H Schmidt, John M. Nickerson, Charles B. Wright, Stephanie L. Foster, Micah A Chrenek, Jeffrey H Boatright
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose To investigate whether treatment with xanthohumol (XN), the principal prenylated chalconoid from Humulus lupulus (hops), is protective in a mouse model of light-induced retinal degeneration (LIRD). Methods Mice (129S2/SvPasCrl) were intraperi
Publikováno v:
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, vol 36, iss 1
In this study, we describe efforts by the National Eye Institute (NEI) and National Center for Advancing Translational Science (NCATS) to catalyze advances in 3-dimensional (3-D) ocular organoid and microphysiological systems (MPS). We reviewed the r
Autor:
Mark E. Kleinman, Charles B. Wright, Younghee Kim, Bradley D. Gelfand, Nagaraj Kerur, Shengjian Li, Philippe Georgel, Ana Bastos-Carvalho, Youn Seon Han, Dingyuan Lou, Joshua L. Dunaief, W. Hayes McDonald, Tetsuhiro Yasuma, Annette Uittenbogaard, Benjamin J. Fowler, Gabriel Núñez, Jayakrishna Ambati, Reo Yasuma
Publikováno v:
Cell Reports, Vol 11, Iss 11, Pp 1686-1693 (2015)
Excess iron induces tissue damage and is implicated in age-related macular degeneration (AMD). Iron toxicity is widely attributed to hydroxyl radical formation through Fenton's reaction. We report that excess iron, but not other Fenton catalytic meta
Autor:
David R. Hinton, Shoba Amarnath, Takeshi Mizutani, Bradley D. Gelfand, Ana Bastos-Carvalho, Benjamin J. Fowler, Hitesh K. Agarwal, Valeria Tarallo, Charles B. Wright, Reo Yasuma, Shengjian Li, Marta Radwan, Nagaraj Kerur, Paul Kubes, Tetsuhiro Yasuma, Younghee Kim, Keykavous Parang, Keir Pittman, Yoshio Hirano, Jayakrishna Ambati, Daniel H. Fowler, Mark T. Young
Publikováno v:
Science. 346:1000-1003
Nucleoside reverse transcriptase inhibitors (NRTIs) are mainstay therapeutics for HIV that block retrovirus replication. Alu (an endogenous retroelement that also requires reverse transcriptase for its life cycle)–derived RNAs activate P2X7 and the
Publikováno v:
Nature biotechnology. 35(9)
PhD trainees aspiring to become faculty need to know the credentials search committees value most in an applicant.
Publikováno v:
Journal of health politics, policy and law. 42(4)
Following passage of the Patient Protection and Affordable Care Act (ACA) in the United States, the Kentucky Health Benefit Exchange, Kynect, began operating in Kentucky in October 2013. Kentucky expanded Medicaid eligibility in January 2014. Togethe