Zobrazeno 1 - 10
of 136
pro vyhledávání: '"Charles B. Malpas"'
Autor:
Roxane Dilcher, Charles B. Malpas, Mark Walterfang, Dennis Velakoulis, Terence J. O’Brien, Lucy Vivash
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
In a large proportion of individuals with fronto-temporal lobar degeneration (FTLD), the underlying pathology is associated with the misfolding and aggregation of the microtubule associated protein tau (FTLD-tau). With disease progression, widespread
Externí odkaz:
https://doaj.org/article/4a70ce61ec5547999ad2a0fa8a0b34dd
Autor:
Nicholas M. Burgess, Wendy Kelso, Charles B. Malpas, Toby Winton-Brown, Timothy Fazio, Julie Panetta, Gerard De Jong, Joanna Neath, Sonny Atherton, Dennis Velakoulis, Mark Walterfang
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 16, Iss 1, Pp 1-8 (2021)
Abstract Background Phenylketonuria (PKU) is an autosomal recessive inherited disorder characterised by a deficiency in phenylalanine hydroxylase. Untreated, PKU is associated with a wide range of cognitive and psychiatric sequelae. Contemporary mana
Externí odkaz:
https://doaj.org/article/461833f33f574b35a09a446f56ee377f
Autor:
Lucy Vivash, Charles B. Malpas, Christian Meletis, Meghan Gollant, Dhamidhu Eratne, Qiao‐Xin Li, Stuart McDonald, William T. O'Brien, Amy Brodtmann, David Darby, Christopher Kyndt, Mark Walterfang, Christopher M. Hovens, Dennis Velakoulis, Terence J. O'Brien
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 8, Iss 1, Pp n/a-n/a (2022)
Abstract Introduction Sodium selenate increases tau dephosphorylation through protein phosphatase 2 activation. Here we report an open‐label Phase 1b study of sodium selenate as a disease‐modifying treatment for behavioral variant frontotemporal
Externí odkaz:
https://doaj.org/article/2208b7c2a982408199bac2e4e96fdce6
Autor:
Howard Chiu, Sila Genc, Charles B. Malpas, Emma Sciberras, Jan M. Nicholson, Daryl Efron, Timothy J. Silk
Publikováno v:
Brain Disorders, Vol 4, Iss , Pp 100023- (2021)
Children with attention-deficit/hyperactivity disorder (ADHD) have poor academic functioning compared to typically developing children, with executive dysfunction mediating the relationship between ADHD symptoms and academic outcomes. This study inve
Externí odkaz:
https://doaj.org/article/01ddab4c75f0434aa307caeec4a7fcff
Autor:
Sila Genc, Charles B. Malpas, Alisha Gulenc, Emma Sciberras, Daryl Efron, Timothy J. Silk, Marc L. Seal
Publikováno v:
Developmental Cognitive Neuroscience, Vol 45, Iss , Pp 100853- (2020)
The pubertal period involves dynamic white matter development. This period also corresponds with rapid gains in higher cognitive functions including attention, as well as increased risk of developing mental health difficulties. This longitudinal stud
Externí odkaz:
https://doaj.org/article/ae0f2b0604fb4e47a0258223eefbb60d
Autor:
Joseph Yuan-Mou Yang, Richard Beare, Michelle Hao Wu, Sarah M. Barton, Charles B. Malpas, Chun-Hung Yeh, A. Simon Harvey, Vicki Anderson, Wirginia J. Maixner, Marc Seal
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
BackgroundOptic radiation (OR) tractography may help predict and reduce post-neurosurgical visual field deficits. OR tractography methods currently lack pediatric and surgical focus.PurposeWe propose a clinically feasible OR tractography strategy in
Externí odkaz:
https://doaj.org/article/b7a359a045e24e77b917d2d3f6299531
Autor:
Tomas Kalincik, Charles B Malpas, Michael Dickinson, Izanne Roos, Stefanie Roberts, Samantha M Loi, Mark Dowling, Carmela Sales, Fiore D’Aprano, Valeriya Kuznetsova, Harsh Oza, Hannah Rosenfeld, Samantha van der Linde, Simon J Harrison, Mary Ann Anderson
Publikováno v:
BMJ Neurology Open, Vol 6, Iss 2 (2024)
Introduction Immune effector cell-associated neurotoxicity syndrome (ICANS) is a common side-effect of chimeric antigen receptor T-cell (CAR-T) therapy, with symptoms ranging from mild to occasionally life-threatening. The neurological, cognitive, ps
Externí odkaz:
https://doaj.org/article/77fbcbb4426d477e8b59a88ae23e1602
Autor:
Lucy Vivash, Dennis Velakoulis, Terence J O’Brien, Charles B Malpas, Amy Brodtmann, Christopher M Hovens, Steven Collins, Stephen Macfarlane
Publikováno v:
BMJ Neurology Open, Vol 3, Iss 2 (2021)
Introduction Sodium selenate is a potential disease-modifying treatment for Alzheimer’s disease (AD) which reduces hyperphosphorylated tau through activation of the protein phosphatase 2A enzyme. We have shown sodium selenate to be safe and well to
Externí odkaz:
https://doaj.org/article/c635a5b7fee8411fa1aea2b913960bf3
Publikováno v:
Journal of Alzheimer's Disease. :1-20
Behavioral variant frontotemporal dementia (bvFTD) belongs to the spectrum of frontotemporal lobar degeneration (FTLD) and is characterized by frontal dysfunction with executive deficits and prominent socio-emotional impairments. Social cognition, su
Autor:
Matthew J. Y. Kang, Dhamidhu Eratne, Hannah Dobson, Charles B. Malpas, Michael Keem, Courtney Lewis, Jasleen Grewal, Vivian Tsoukra, Christa Dang, Ramon Mocellin, Tomas Kalincik, Alexander F. Santillo, Henrik Zetterberg, Kaj Blennow, Christiane Stehmann, Shiji Varghese, Qiao-Xin Li, Colin L. Masters, Steven Collins, Samuel F. Berkovic, Andrew Evans, Wendy Kelso, Sarah Farrand, Samantha M. Loi, Mark Walterfang, Dennis Velakoulis
Publikováno v:
Acta Neuropsychiatrica. :1-12
Objective: People with neuropsychiatric symptoms often experience delay in accurate diagnosis. Although cerebrospinal fluid neurofilament light (CSF NfL) shows promise in distinguishing neurodegenerative disorders (ND) from psychiatric disorders (PSY