Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Charles Awortwe"'
Autor:
Oelfah Patel, Christo J. F. Muller, Elizabeth Joubert, Bernd Rosenkranz, Johan Louw, Charles Awortwe
Publikováno v:
Frontiers in Clinical Diabetes and Healthcare, Vol 3 (2022)
Rooibos (Aspalathus linearis), an indigenous South African plant and its major flavonoid, aspalathin, exhibited positive effects on glycemia and dyslipidemia in animal studies. Limited evidence exists on the effects of rooibos extract taken in combin
Externí odkaz:
https://doaj.org/article/0c7231b6a27442e5809bc2b538b12803
Autor:
Oelfah Patel, Christo J F Muller, Elizabeth Joubert, Bernd Rosenkranz, Johan Louw, Charles Awortwe
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0251069 (2021)
Oral therapeutics used to treat type 2 diabetes and cardiovascular disease often fail to prevent the progression of disease and their comorbidities. Rooibos (Aspalathus linearis), an endemic South African plant used as an herbal tea, has demonstrated
Externí odkaz:
https://doaj.org/article/5db923952a7d4afbb43dccac2027af97
Autor:
Oelfah Patel, Christo J.F. Muller, Elizabeth Joubert, Bernd Rosenkranz, Malcolm J.C. Taylor, Johan Louw, Charles Awortwe
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
An aspalathin-rich green rooibos extract (Afriplex GRT™) has demonstrated anti-diabetic and hypolipidemic properties, while also moderately inhibiting CYP3A4 activity, suggesting a potential for herb–drug interaction. The present study, therefore
Externí odkaz:
https://doaj.org/article/e5fe5de090904c1faf135eda0e6cc094
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 17, Iss 1 (2014)
The Caco-2 model is employed in pre-clinical investigations to predict the likely gastrointestinal permeability of drugs because it expresses cytochrome P450 enzymes, transporters, microvilli and enterocytes of identical characteristics to the human
Externí odkaz:
https://doaj.org/article/39ddf01f45024c1e9c78cfd8cc699fce
Autor:
Oelfah Patel, Christo Muller, Elizabeth Joubert, Johan Louw, Bernd Rosenkranz, Charles Awortwe
Publikováno v:
Molecules, Vol 21, Iss 11, p 1515 (2016)
Rooibos extract, due to its glucose and lipid lowering effects, has potential as a nutraceutical for improvement of metabolic dysfunction. Potential herb-drug interactions as a result of the use of natural products are of increasing concern. Cytochro
Externí odkaz:
https://doaj.org/article/cd2779393196420a83feeb1bebf7133b
Autor:
Nicholas E. Thomford, Charles Awortwe, Kevin Dzobo, Faustina Adu, Denis Chopera, Ambroise Wonkam, Michelle Skelton, Dee Blackhurst, Collet Dandara
Publikováno v:
Molecules, Vol 21, Iss 2, p 211 (2016)
Highly active antiretroviral therapy (HAART) has greatly improved health parameters of HIV infected individuals. However, there are several challenges associated with the chronic nature of HAART administration. For populations in health transition, d
Externí odkaz:
https://doaj.org/article/5d4bc88accb8454cb9bc6e0f15f61b6a
Publikováno v:
Molecular Pharmaceutics. 18:1622-1633
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Molecular Pharmaceutics, copyright © 2021 American Chemical Societ, after peer review and technical editing by the publisher. To access the final edi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf73c41eef2fa133409c47980c7e5da2
https://doi.org/10.1021/acs.molpharmaceut.0c01075
https://doi.org/10.1021/acs.molpharmaceut.0c01075
Publikováno v:
OMICS: A Journal of Integrative Biology
What would it take in terms of the structural reforms in science, technology, and culture to cultivate sustainable therapeutic and preventive medicine innovations against zoonotic infections such as coronavirus disease 2019 (COVID-19) in the 21st cen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4b380a91967522ec16f5ec1dc5b1752
https://doi.org/10.1089/omi.2020.0150
https://doi.org/10.1089/omi.2020.0150
Autor:
Lena Radtke, Aleksandra Majchrzak-Celińska, Charles Awortwe, Inga Vater, Inga Nagel, Susanne Sebens, Ingolf Cascorbi, Meike Kaehler
Publikováno v:
Pharmacological Research. 185:106510
Glioblastoma multiforme (GBM) is the most common malignant brain tumor with limited therapeutic options. Besides surgery, chemotherapy using temozolomide, carmustine or lomustine is the main pillar of therapy. However, therapy success is limited and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a138fdb4b572c3e18a944d30c2763a9
https://doi.org/10.1016/j.phrs.2022.106510
https://doi.org/10.1016/j.phrs.2022.106510
Publikováno v:
Pharmacological Research. 141:397-408
Although several studies on pharmacokinetic and/or pharmacodynamic herb–drug interactions (HDI) have been conducted in healthy volunteers, there is large uncertainty on the validity of these studies. A qualitative review and a meta-analysis were pe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9c95e4786406c3a280853d27dc9ae2d
https://doi.org/10.1016/j.phrs.2019.01.028
https://doi.org/10.1016/j.phrs.2019.01.028