Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Charles Askew"'
Autor:
Xiaolei Pei, Wenwei Shao, Allene Xing, Charles Askew, Xiaojing Chen, Caibin Cui, Yasmina L. Abajas, David A. Gerber, Elizabeth P. Merricks, Timothy C. Nichols, Wuping Li, R. Jude Samulski, Chengwen Li
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss , Pp 259-268 (2020)
Adeno-associated virus (AAV) vectors have been successfully used in patients with bleeding disorders and blindness. For human liver targeting, two major factors restrict effective AAV transduction after systemic administration of AAV vectors: human h
Externí odkaz:
https://doaj.org/article/ffd1eccee8e6456aa953cf4176aa8c2d
Autor:
Graham Casey, Charles Askew, Mark A Brimble, R Jude Samulski, Andrew M Davidoff, Chengwen Li, Bradley J Walters
Publikováno v:
PLoS ONE, Vol 15, Iss 11, p e0242599 (2020)
Sensorineural hearing loss is one of the most common disabilities worldwide. Such prevalence necessitates effective tools for studying the molecular workings of cochlear cells. One prominent and effective vector for expressing genes of interest in re
Externí odkaz:
https://doaj.org/article/38da7f9e5766456c8a836bcde114effe
Autor:
Matthew R Avenarius, Jae-Yun Jung, Charles Askew, Sherri M Jones, Kristina L Hunker, Hela Azaiez, Atteeq U Rehman, Margit Schraders, Hossein Najmabadi, Hannie Kremer, Richard J H Smith, Gwenaëlle S G Géléoc, David F Dolan, Yehoash Raphael, David C Kohrman
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0201713 (2018)
Hearing and balance depend upon the precise morphogenesis and mechanosensory function of stereocilia, the specialized structures on the apical surface of sensory hair cells in the inner ear. Previous studies of Grxcr1 mutant mice indicated a critical
Externí odkaz:
https://doaj.org/article/1b9954a009804b34a68d58ca662b8503
Publikováno v:
Advanced Therapeutics. 5:2200128
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35e3cda4ee60547b4cd854b1bce87803
https://doi.org/10.1002/adtp.202200128
https://doi.org/10.1002/adtp.202200128
Autor:
Bradley J Walters, Charles Askew, Andrew M. Davidoff, Graham R. Casey, R. Jude Samulski, Mark A. Brimble, Chengwen Li
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 11, p e0242599 (2020)
PLoS ONE, Vol 15, Iss 11, p e0242599 (2020)
Sensorineural hearing loss is one of the most common disabilities worldwide. Such prevalence necessitates effective tools for studying the molecular workings of cochlear cells. One prominent and effective vector for expressing genes of interest in re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce2223a07c31832b99892c0dd670eee8
https://pubmed.ncbi.nlm.nih.gov/33227033
https://pubmed.ncbi.nlm.nih.gov/33227033
Autor:
Timothy C. Nichols, Allene Xing, David A. Gerber, Yasmina L. Abajas, Wuping Li, R. Jude Samulski, Cai-Bin Cui, Wenwei Shao, Chengwen Li, Xiaolei Pei, Xiaojing Chen, Charles Askew, Elizabeth P. Merricks
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss, Pp 259-268 (2020)
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss, Pp 259-268 (2020)
Adeno-associated virus (AAV) vectors have been successfully used in patients with bleeding disorders and blindness. For human liver targeting, two major factors restrict effective AAV transduction after systemic administration of AAV vectors: human h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a516ee77262b7a400dfb725fe7d046de
https://pubmed.ncbi.nlm.nih.gov/32637455
https://pubmed.ncbi.nlm.nih.gov/32637455
Autor:
Xintao Zhang, Zheng Chai, Amanda Lee Dobbins, Michelle S. Itano, Charles Askew, Zhe Miao, Hongqian Niu, R. Jude Samulski, Chengwen Li
Publikováno v:
Biomaterials
Recombinant adeno-associated virus (rAAV) vectors have been widely used as favored delivery vehicles for the treatment of inherited diseases in clinical trials, including neurological diseases. However, the noninvasive systemic delivery of rAAV to th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c885e3b6ac9193e2d09c8a23750f489
https://doi.org/10.1016/j.biomaterials.2021.121340
https://doi.org/10.1016/j.biomaterials.2021.121340
Autor:
Andrew Forge, Alice Galvin, Konstantina M. Stankovic, Bifeng Pan, Jeffrey R. Holt, Lukas D. Landegger, Sarah Wassmer, Luk H. Vandenberghe, Ruth Taylor, Sarah D. Gluck, Charles Askew
Publikováno v:
Nature biotechnology
Efforts to develop gene therapies for hearing loss have been hampered by the lack of safe, efficient, and clinically relevant delivery modalities1, 2. Here we demonstrate the safety and efficiency of Anc80L65, a rationally designed synthetic vector3,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d159d4151930389955ed8956545873d
https://doi.org/10.1038/nbt.3781
https://doi.org/10.1038/nbt.3781
Autor:
Alice Galvin, Michelle L. Hastings, Luk H. Vandenberghe, Francine M. Jodelka, Artur A. Indzhykulian, Gwenaelle G.S. Géléoc, Jennifer J Lentz, Charles Askew, Selena Heman-Ackah, Jeffrey R. Holt, Yukako Asai, Bifeng Pan
Publikováno v:
Nature biotechnology
Gene therapy in the inner ear achieves unprecedented recovery of hearing and balance behavior in Usher syndrome mice. Because there are currently no biological treatments for hearing loss, we sought to advance gene therapy approaches to treat genetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f7bd1e1677a0cdec798cab312e8bf41
http://europepmc.org/articles/PMC5340578
http://europepmc.org/articles/PMC5340578
Autor:
Kevin E. Fox, William C. Scott, Kendall A. Hutson, Maheer M. Masood, Douglas C. Fitzpatrick, Charles Askew, J. David Wilson, Christopher K. Giardina, Stephen H. Pulver, Gilberto David Graña, Andrew K. Pappa
Publikováno v:
J Neurophysiol
The cochlear summating potential (SP) to a tone is a baseline shift that persists for the duration of the burst. It is often considered the most enigmatic of cochlear potentials because its magnitude and polarity vary across frequency and level and i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75f5061d96649b973a978b4e87ece0c4
https://pubmed.ncbi.nlm.nih.gov/30943095
https://pubmed.ncbi.nlm.nih.gov/30943095