Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Charles Arber"'
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Amyloid precursor protein (APP) and its cleavage fragment Amyloid-β (Aβ) have fundamental roles in Alzheimer’s disease (AD). Genetic alterations that either increase the overall dosage of APP or alter its processing to favour the generation of lo
Externí odkaz:
https://doaj.org/article/6f3e44cfa54b48cf98810e87979739ac
Autor:
Charles Arber, Christopher Lovejoy, Lachlan Harris, Nanet Willumsen, Argyro Alatza, Jackie M. Casey, Georgie Lines, Caoimhe Kerins, Anika K. Mueller, Henrik Zetterberg, John Hardy, Natalie S. Ryan, Nick C. Fox, Tammaryn Lashley, Selina Wray
Publikováno v:
Cell Reports, Vol 34, Iss 2, Pp 108615- (2021)
Summary: Mutations in presenilin 1 (PSEN1) or presenilin 2 (PSEN2), the catalytic subunit of γ-secretase, cause familial Alzheimer’s disease (fAD). We hypothesized that mutations in PSEN1 reduce Notch signaling and alter neurogenesis. Expression d
Externí odkaz:
https://doaj.org/article/7f979cc3b908483da5f10f85ac910f06
Autor:
Jamie Toombs, Martha S. Foiani, Henrietta Wellington, Ross W. Paterson, Charles Arber, Amanda Heslegrave, Michael P. Lunn, Jonathan M. Schott, Selina Wray, Henrik Zetterberg
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 10, Iss 1, Pp 311-321 (2018)
Abstract Introduction We tested the hypothesis that the amyloid β (Aβ) peptide ratios are more stable than Aβ42 alone when biofluids are exposed to two preanalytical conditions known to modify measurable Aβ concentration. Methods Human cerebrospi
Externí odkaz:
https://doaj.org/article/3548c29662c64b45a557c5845bb4dac5
Autor:
Anna Mallach, Johan Gobom, Charles Arber, Thomas M. Piers, John Hardy, Selina Wray, Henrik Zetterberg, Jennifer Pocock
Publikováno v:
Cells, Vol 10, Iss 11, p 2866 (2021)
Microglial exosomes are an emerging communication pathway, implicated in fulfilling homeostatic microglial functions and transmitting neurodegenerative signals. Gene variants of triggering receptor expressed on myeloid cells-2 (TREM2) are associated
Externí odkaz:
https://doaj.org/article/e5f7dfff72ee4e26a9361a11d732053f
Publikováno v:
Alzheimer’s Research & Therapy, Vol 9, Iss 1, Pp 1-17 (2017)
Abstract A major challenge to our understanding of the molecular mechanisms of Alzheimer’s disease (AD) has been the lack of physiologically relevant in vitro models which capture the precise patient genome, in the cell type of interest, with physi
Externí odkaz:
https://doaj.org/article/d1d7dc0400d54b04a411337757850849
Autor:
Charles Arber, Plamena R Angelova, Sarah Wiethoff, Yugo Tsuchiya, Francesca Mazzacuva, Elisavet Preza, Kailash P Bhatia, Kevin Mills, Ivan Gout, Andrey Y Abramov, John Hardy, James A Duce, Henry Houlden, Selina Wray
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0184104 (2017)
Mutations in PANK2 lead to neurodegeneration with brain iron accumulation. PANK2 has a role in the biosynthesis of coenzyme A (CoA) from dietary vitamin B5, but the neuropathological mechanism and reasons for iron accumulation remain unknown. In this
Externí odkaz:
https://doaj.org/article/f5f6c31baff54e20bd2c981bf542ab13
Autor:
Nanet Willumsen, Charles Arber, Christopher Lovejoy, Jamie Toombs, Argyro Alatza, Philip S J Weston, Lucia Chávez-Gutiérrez, John Hardy, Henrik Zetterberg, Nick C Fox, Natalie S Ryan, Tammaryn Lashley, Selina Wray
Publikováno v:
Brain Communications. 5
Mutations in the presenilin 1 gene, PSEN1, which cause familial Alzheimer's disease alter the processing of amyloid precursor protein, leading to the generation of various amyloid-β peptide species. These species differ in their potential for aggreg
Publikováno v:
GliaREFERENCES.
One form of early life stress, prenatal exposure to glucocorticoids (GCs), confers a higher risk of psychiatric and neurodevelopmental disorders in later life. Increasingly, the importance of microglia in these disorders is recognized. Studies on GCs
Autor:
Emil K. Gustavsson, Siddharth Sethi, Yujing Gao, Jonathan W. Brenton, Sonia García-Ruiz, David Zhang, Raquel Garza, Regina H. Reynolds, James R. Evans, Zhongbo Chen, Melissa Grant-Peters, Hannah Macpherson, Kylie Montgomery, Rhys Dore, Anna I. Wernick, Charles Arber, Selina Wray, Sonia Gandhi, Julian Esselborn, Cornelis Blauwendraat, Christopher H. Douse, Anita Adami, Diahann A.M. Atacho, Antonina Kouli, Annelies Quaegebeur, Roger A. Barker, Elisabet Englund, Frances Platt, Johan Jakobsson, Nicholas W. Wood, Henry Houlden, Harpreet Saini, Carla F. Bento, John Hardy, Mina Ryten
The human genome contains numerous duplicated regions, such as parent-pseudogene pairs, causing sequencing reads to align equally well to either gene. The extent to which this ambiguity complicates transcriptomic analyses is currently unknown. This i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6aef8c29ea97f0d880be74d785ceca3d
https://doi.org/10.1101/2022.10.21.513169
https://doi.org/10.1101/2022.10.21.513169
Autor:
Ross W. Paterson, Argyro Alatza, Claire A Leckey, Henrik Zetterberg, Selina Wray, Charles Arber
Publikováno v:
Journal of Neurochemistry
Induced pluripotent stem cell (iPSC) technology enables the generation of human neurons in vitro, which contain the precise genome of the cell donor, therefore permitting the generation of disease models from individuals with a disease‐associated g