Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Charles A. Yowell"'
Autor:
Massimiliano S. Tagliamonte, Charles A. Yowell, Maha A. Elbadry, Jacques Boncy, Christian P. Raccurt, Bernard A. Okech, Erica M. Goss, Marco Salemi, John B. Dame
Publikováno v:
mSphere, Vol 5, Iss 5 (2020)
ABSTRACT The malaria parasite, Plasmodium falciparum, was introduced into Hispaniola and other regions of the Americas through the slave trade spanning the 16th through the 19th centuries. During this period, more than 12 million Africans were brough
Externí odkaz:
https://doaj.org/article/0000e17190e246e6b2621356f3ffcae1
Autor:
Peng Liu, Arthur H Robbins, Melissa R Marzahn, Scott H McClung, Charles A Yowell, Stanley M Stevens, John B Dame, Ben M Dunn
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0141758 (2015)
The rodent malaria parasite Plasmodium berghei is a practical model organism for experimental studies of human malaria. Plasmepsins are a class of aspartic proteinase isoforms that exert multiple pathological effects in malaria parasites. Plasmepsins
Externí odkaz:
https://doaj.org/article/2de89a511b534b3e84d8c1f4eb95efe1
Autor:
Massimiliano S. Tagliamonte, Bernard A. Okech, Maha A. Elbadry, Marco Salemi, John B. Dame, Christian Raccurt, Erica M. Goss, Charles A. Yowell, Jacques Boncy
Publikováno v:
mSphere, Vol 5, Iss 5 (2020)
mSphere
mSphere
Historical data suggest that millions of P. falciparum parasite lineages were introduced into the Americas during the trans-Atlantic slave trade, which would suggest a paraphyletic origin of the extant isolates in the Western Hemisphere. Our analyses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7559289d1361d58fc4f6777af94040e
https://journals.asm.org/doi/10.1128/mSphere.00937-20
https://journals.asm.org/doi/10.1128/mSphere.00937-20
Autor:
Antonette Bennett, Kimberly E. Wooten, John B. Dame, Larry R. Jackson, Sibani Chakraborty, Ben M. Dunn, Mavis Agbandje-McKenna, Jose Clemente, Minh Ngo, Rebecca E. Moose, Richard Chang, Charles A. Yowell
Publikováno v:
Biochemistry. 46:14198-14205
The nematode Ascaris suum primarily infects pigs, but also causes disease in humans. As part of its survival mechanism in the intestinal tract of the host, the worm produces a number of protease inhibitors, including pepsin inhibitor-3 (PI3), a 17 kD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e85c9fdcbb26ecba0a9ceb3ae4138602
https://doi.org/10.1021/bi7014844
https://doi.org/10.1021/bi7014844
Publikováno v:
Molecular Microbiology. 65:64-75
Knockout mutants of Plasmodium falciparum lacking pfpm1, pfpm2 and pfhap (triple-PM KO), and mutants lacking all four digestive vacuole (DV) plasmepsins (pfpm4, pfpm1, pfpm2 and pfhap; quadruple-PM KO), were prepared by double cross-over integration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c522371959baced8cb1f48677fb66b9a
https://doi.org/10.1111/j.1365-2958.2007.05768.x
https://doi.org/10.1111/j.1365-2958.2007.05768.x
Autor:
John B. Dame, Pedro A. Moura, Tonya D. Bonilla, J. Alfredo Bonilla, Charles A. Yowell, David A. Fidock
Publikováno v:
International Journal for Parasitology. 37:317-327
Four of the plasmepsins of Plasmodium falciparum are localised in the digestive vacuole (DV) of the asexual blood stage parasite (PfPM1, PfPM2, PfPM4 and PfHAP), and each of these aspartic proteinases has been successfully targeted by gene disruption
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dce197c7098d0ec27cd71ebda1449da
https://doi.org/10.1016/j.ijpara.2006.11.008
https://doi.org/10.1016/j.ijpara.2006.11.008
Autor:
S.Z. Fisher, Ben M. Dunn, Robert McKenna, Rebecca E. Moose, Yoshiaki Kiso, Charles A. Yowell, Amrita Madabushi, Jose Clemente, Lakshmanan Govindasamy, Tooru Kimura, Mavis Agbandje-McKenna, Yoshio Hayashi, Koushi Hidaka, John B. Dame
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 62:246-252
The malarial parasite continues to be one of the leading causes of death in many developing countries. With the development of resistance to the currently available treatments, the discovery of new therapeutics is imperative. Currently, the plasmepsi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0415d12b75d57f5349ddd19f005d083
https://doi.org/10.1107/s0907444905041260
https://doi.org/10.1107/s0907444905041260
Publikováno v:
Molecular and Biochemical Parasitology. 140:107-117
We have previously reported the presence of a DNA gyrase-like topoisomerase activity associated with the 35kb apicoplast DNA in the malarial parasite Plasmodium falciparum [Weissig V, Vetro-Widenhouse TS, Rowe TC. Topoisomerase II inhibitors induce c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd3b13229acdd0bb92b597d2a340a22c
https://doi.org/10.1016/j.molbiopara.2004.12.013
https://doi.org/10.1016/j.molbiopara.2004.12.013
Autor:
Patrick J. Kelly, Elizabeth A. Kasbohm, Gargi Bagchi, Patrick J. Casey, Rishu Guo, Yehia Daaka, Puneeta Arora, Charles W. Yowell
Publikováno v:
Journal of Biological Chemistry. 280:11583-11589
The androgen receptor (AR) is activated in prostate cancer patients undergoing androgen ablative therapy and mediates growth of androgen-insensitive prostate cancer cells, suggesting it is activated by nonandrogenic factors. We demonstrate that activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31d93e67fff07e72f9061e834a7cc6b9
https://doi.org/10.1074/jbc.m414423200
https://doi.org/10.1074/jbc.m414423200
Autor:
Minh T. Lam, Bret B. Beyer, John B. Dame, Ben M. Dunn, Jennifer Westling, Charles A. Yowell, Tang Li, Su-Hwi Hung
Publikováno v:
Molecular and Biochemical Parasitology. 135:101-109
Plasmepsin 4 from Plasmodium falciparum and orthologs from Plasmodium malariae , Plasmodium ovale and Plasmodium vivax have been expressed in recombinant form, and properties of the active site of each enzyme characterized by kinetic analysis. A pane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41e7e02bf1a6c98979021d7aaab3cf83
https://doi.org/10.1016/j.molbiopara.2004.01.010
https://doi.org/10.1016/j.molbiopara.2004.01.010