Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Charles A. Wuertzer"'
Autor:
Xin Yu, Baoli Yang, Simon D'Alton, Joshua Knight, Ian M. Farnham, Rachel M. Bailey, Yong Jie Zhang, John Howard, Monica Castanedes-Casey, Matthew R. Sarkisian, Brittany Scott, Jada Lewis, Linda Rousseau, Ashley Cannon, Dennis W. Dickson, Wen-Lang Lin, Leonard Petrucelli, Michael Jurasic, Charles A. Wuertzer
Publikováno v:
Acta Neuropathologica
Ubiquitin-immunoreactive neuronal inclusions composed of TAR DNA binding protein of 43 kDa (TDP-43) are a major pathological feature of frontotemporal lobar degeneration (FTLD-TDP). In vivo studies with TDP-43 knockout mice have suggested that TDP-43
Autor:
Charles A. Wuertzer, Archibald S. Perkins, Gouri Chatterjee, Lucie Coillard, Fernando D. Camargo, Subhash C. Juneja, Yi Zhang, Kimberly Lezon-Geyda, Sandra Stehling-Sun
Publikováno v:
Blood. 118:3853-3861
The Mds1 and Evi1 complex locus (Mecom) gives rise to several alternative transcripts implicated in leukemogenesis. However, the contribution that Mecom-derived gene products make to normal hematopoiesis remains largely unexplored. To investigate the
Autor:
Zeshan, Ahmed, Hong, Sheng, Ya-Fei, Xu, Wen-Lang, Lin, Amy E, Innes, Jennifer, Gass, Xin, Yu, Charles A, Wuertzer, Harold, Hou, Shuichi, Chiba, Keitaro, Yamanouchi, Malcolm, Leissring, Leonard, Petrucelli, Masugi, Nishihara, Michael L, Hutton, Eileen, McGowan, Dennis W, Dickson, Jada, Lewis
Publikováno v:
The American Journal of Pathology. 177:311-324
Progranulin (PGRN) is involved in wound repair, inflammation, and tumor formation, but its function in the central nervous system is unknown. Roles in development, sexual differentiation, and long-term neuronal survival have been suggested. Mutations
Publikováno v:
Molecular Therapy. 16:481-486
A unifying characteristic of prion diseases is the conversion of a normal cellular protein (PrP c ) to an abnormal pathogenic conformation, designated PrP sc . Antibodies directed against PrP c , when added to scrapie-infected cell cultures or passiv
Autor:
Kathleen A. Maguire-Zeiss, Douglas W. Short, Eric Yehling, Charlotte I. Wang, Xiaomin Su, Leigh A. Henricksen, Charles A. Wuertzer, Mark A. Sullivan, Geraldine Gouzer, Howard J. Federoff
Publikováno v:
Biochemical and Biophysical Research Communications. 349:1198-1205
Parkinson's disease (PD) is a common neurodegenerative disease of unknown etiology. Evidence suggests a role for protein misfolding in disease pathogenesis. One pathologic feature observed in dopaminergic neurons is the intracytoplasmic eosinophilic
Publikováno v:
Molecular Therapy
Transmissible spongiform encephalopathies (TSE) are characterized by the conversion of a normal cellular protein (PrPc) to an abnormal disease causing conformation, designated PrPsc. Efforts to use antibodies to alter the rate of conversion of PrPc t
Autor:
Archibald S. Perkins, Xiaohui Cui, Ramana V. Davuluri, Ying Yi Xiao, Yingtao Bi, Michael P Wilson, Yi Zhang, Charles A. Wuertzer, Kristina Owens, Carolyn Glass
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 6, p e67134 (2013)
PLoS ONE, Vol 8, Iss 6, p e67134 (2013)
The ecotropic virus integration site 1 (EVI1) transcription factor is associated with human myeloid malignancy of poor prognosis and is overexpressed in 8-10% of adult AML and strikingly up to 27% of pediatric MLL-rearranged leukemias. For the first
Autor:
Marion Vogel, Kimberly Lezon-Geyda, Xiaohui Cui, Katy A. Muzikar, Daniel A. Harki, Peter B. Dervan, Archibald S. Perkins, Daniel A. Stolper, John Wheeler, Géraldine Sicot, Yi Zhang, Charles A. Wuertzer
The zinc finger protein EVI1 is causally associated with acute myeloid leukemogenesis, and inhibition of its function with a small molecule therapeutic may provide effective therapy for EVI1-expressing leukemias. In this paper we describe the develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::974fba31bb1e710f387bb8daa2894806
https://resolver.caltech.edu/CaltechAUTHORS:20120105-071520702
https://resolver.caltech.edu/CaltechAUTHORS:20120105-071520702
Autor:
Brittany Scott, Simon D'Alton, Mackenzie Farnham, Yong Jie Zhang, John Howard, Joshua Knight, Rachel M. Bailey, Ashley Cannon, Baoli Yang, Leonard Petrucelli, Michael Jurasic, Xin Yu, Wen-Lang Lin, Jada Lewis, Dennis W. Dickson, Charles A. Wuertzer
Publikováno v:
Alzheimer's & Dementia. 7
Publikováno v:
Current gene therapy. 6(3)
Strategies that employ HSV amplicon vectors in the prevention and/or amelioration of pathogenic states afflicting the central nervous system (CNS) have been extensively documented in preclinical disease models. The versatility of the HSV amplicon pla