Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Charles A. Strott"'
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 6, Pp 1343-1352 (2007)
Oxysterols constitute a class of cholesterol derivatives that exhibit broad biological effects ranging from cytotoxicity to regulation of nuclear receptors. The role of oxysterols such as 7-ketocholesterol (7-KC) in the development of retinal macular
Externí odkaz:
https://doaj.org/article/1bcabd1139164d0fae3c25347dc7d12d
Autor:
Charles A. Strott, Yuko Higashi
Publikováno v:
Journal of Lipid Research, Vol 44, Iss 7, Pp 1268-1278 (2003)
Cholesterol sulfate is quantitatively the most important known sterol sulfate in human plasma, where it is present in a concentration that overlaps that of the other abundant circulating steroid sulfate, dehydroepiandrosterone (DHEA) sulfate. Althoug
Externí odkaz:
https://doaj.org/article/0f5d02e30f3246c184d8b6d921db6dc3
Publikováno v:
Neuroscience Letters. 430:75-80
The neurosteroid pregnenolone sulfate (PREGS), which is synthesized in glial cells, plays a significant role in learning and memory performance. The aim of this study was to investigate the regulation of expression of the steroid sulfotransferase SUL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab5b4988f845810d7987a7b24f7c9d14
https://doi.org/10.1016/j.neulet.2007.10.023
https://doi.org/10.1016/j.neulet.2007.10.023
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 6, Pp 1343-1352 (2007)
Oxysterols constitute a class of cholesterol derivatives that exhibit broad biological effects ranging from cytotoxicity to regulation of nuclear receptors. The role of oxysterols such as 7-ketocholesterol (7-KC) in the development of retinal macular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30243603dd95ee32f7971d6ab6f96007
https://doi.org/10.1194/jlr.m700018-jlr200
https://doi.org/10.1194/jlr.m700018-jlr200
Publikováno v:
Experimental Eye Research. 83:465-469
Sterol 27-hydroxylase (CYP27A1) is a mitochondrial P-450 enzyme with broad substrate specificity for C27 sterols including 7-ketocholesterol (7kCh). CYP27A1 is widely expressed in human tissues but has not been previously demonstrated in the retina.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb45e41ea18abacf82165757218cee63
https://doi.org/10.1016/j.exer.2005.11.018
https://doi.org/10.1016/j.exer.2005.11.018
Publikováno v:
Gene. 367:66-73
cDNAs for rat SULT2B1 steroid/sterol sulfotransferase isoforms were cloned, and the encoded proteins overexpressed, purified and characterized. The rat SULT2B1a isoform avidly sulfonates pregnenolone but poorly utilizes cholesterol as a substrate, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a0ed444e4227360a5d4cae64abd2a59
https://doi.org/10.1016/j.gene.2005.09.009
https://doi.org/10.1016/j.gene.2005.09.009
Publikováno v:
FEBS Letters. 579:3639-3645
The steroid/sterol sulfotransferase gene (SULT2B1) encodes for two isozymes of which one (SULT2B1b) sulfonates cholesterol and is selectively expressed in skin. The human SULT2B1 gene contains neither a TATAAA nor a CCAAT motif upstream of the coding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc19ce5b2b83bb2aa6ede071ca675809
https://doi.org/10.1016/j.febslet.2005.05.041
https://doi.org/10.1016/j.febslet.2005.05.041
Autor:
Yuko Higashi, Tomoko Fukushige, Young Mok Lee, Hirotoshi Fuda, Hidekatsu Yanai, Tamotsu Kanzaki, Charles A. Strott
Publikováno v:
Journal of Investigative Dermatology. 122(5):1207-1213
Cholesterol sulfate is a highly amphipathic molecule that is present in a relatively high concentration in the epidermis of human skin, particularly in the granular layer. The physiologic significance of this finding, however, is not well-understood.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17c281e38cd42ebfc307800385a549ee
Autor:
Masahiko Negishi, Hirotoshi Fuda, Karen A. Lee, Lars C. Pedersen, Young C. Lee, Charles A. Strott
Publikováno v:
Journal of Biological Chemistry. 278:44593-44599
The gene for human hydroxysteroid sulfotransferase (SULT2B1) encodes two peptides, SULT2B1a and SULT2B1b, that differ only at their amino termini. SULT2B1b has a predilection for cholesterol but is also capable of sulfonating pregnenolone, whereas SU
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18cddac8616d2ccc8f1c5b61066e50dc
https://doi.org/10.1074/jbc.m308312200
https://doi.org/10.1074/jbc.m308312200
Autor:
Charles A. Strott
Publikováno v:
Endocrine Reviews. 23:703-732
The sulfonation of endogenous molecules is a pervasive biological phenomenon that is not always easily understood, and although it is increasingly recognized as a function of fundamental importance, there remain areas in which significant cognizance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14113ac4f8b2e2bf8b0766ac9b47cc49
https://doi.org/10.1210/er.2001-0040
https://doi.org/10.1210/er.2001-0040