Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Charles A. Rizzo"'
Autor:
Maria A. Rivelli, John A. Hey, Michel R. Corboz, Jennifer C. Mutter, Stephen Eckel, Lori A. Varty, Charles A. Rizzo, Mark E. Cartwright, John C. Anthes
Publikováno v:
American Journal of Rhinology. 19:495-502
Background Functional α1- and α2-adrenoreceptor subtype pharmacology was characterized in an in vitro human nasal mucosa contractile bioassay. Methods Nasal mucosa was obtained from 49 donor patients and mucosal strips were placed in chambers fille
Autor:
Robert W. Egan, Charles A. Rizzo, L. M. Varty, Craig C. Correll, Richard Yang, John A. Hey, Yanlin Jia, Xin Wang, P. Tara Phelps
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 287:L272-L278
Hypotonic stimulation induces airway constriction in normal and asthmatic airways. However, the osmolarity sensor in the airway has not been characterized. TRPV4 (also known as VR-OAC, VRL-2, TRP12, OTRPC4), an osmotic-sensitive cation channel in the
Autor:
M. Berlin, Hongchen Qiu, Maria A. Rivelli, Shelby P. Umland, James Jakway, Charles A. Rizzo, L. M. Varty, Yuntao Wan, Mccormick Kevin D, John A. Hey, Jennifer C. Mutter, Michel R. Corboz
Publikováno v:
Autonomic and Autacoid Pharmacology. 23:208-219
1. Pig nasal mucosal strips were incubated with alpha-adrenoceptor antagonists followed by alpha2-adrenoceptor agonist concentration-response curves. 2. Contractions elicited by the alpha2-adrenoceptor agonists BHT-920 (pD2 = 6.16 +/- 0.07), UK 14,30
Autor:
Xiomara Fernandez, Michel R. Corboz, Salvatore Tozzi, John A. Hey, Mary Ellen Monahan, Charles A. Rizzo
Publikováno v:
Autonomic and Autacoid Pharmacology. 23:79-93
1. The present study compared the effect of the administration of tachykinin NK1- and NK2-receptor antagonists alone and in combination on exogenous and endogenous tachykinin-induced contractions using three different guinea-pig airway preparations:
Autor:
Piwinski John J, Xiomara Fernandez, Stephen Eckel, Cuss Francis M, John C. Anthes, Richard W. Chapman, Michel R. Corboz, John A. Hey, Greg A. Reichard, Pauline C. Ting, Susan Sehring, Charles A. Rizzo, Yvette Crawley, Robbie L. McLeod, Nick Carruthers, Robert W. Egan, Christian Richard, Scott Greenfeder, M. Motasim Billah, Neng-Yang Shih, William Kreutner
Publikováno v:
European Journal of Pharmacology. 450:191-202
Experiments were performed to characterize the pharmacology of SCH 206272 [(R,R)-1'[5-[(3,5-dichlorobenzoyl)methylamino]-3-(3,4-dichlorophenyl)-4(Z)-(methoxyimino)pentyl]-N-methyl-2-oxo-[1,4'bipiperidine]-3-acetamide] as a potent and selective antago
Autor:
John A. Hey, Charles A. Rizzo, Robert W. Egan, Richard Yang, Romain A. Pauwels, Scott Greenfeder
Publikováno v:
Journal of Allergy and Clinical Immunology. 109:404-409
Background: The role of IL-5–induced eosinophilia in airway hyperresponsiveness has been questioned. In addition, eosinophil-independent IL-5–induced airway hyperresponsiveness has been demonstrated in animals. Objective: In this study, IL-5 was
Autor:
Xin Wang, Maria A. Rivelli, Charles A. Rizzo, Tony Priestley, Michel R. Corboz, Richard Yang, Yanlin Jia, John A. Hey, Sonia I Aponte
Publikováno v:
British Journal of Pharmacology. 135:764-770
Nociceptin/orphanin FQ (N/OFQ), an endogenous opioid-like orphan receptor (NOP receptor, previously termed ORL1 receptor) agonist, has been found to inhibit capsaicin-induced bronchoconstriction in isolated guinea-pig lungs and in vivo. The underlyin
Publikováno v:
Pharmacology. 66:128-135
Optical difference spectroscopy was used to identify and quantify human adrenal microsomal and mitochondrial cytochrome P450 enzyme interactions with the histamine H3 receptor antagonists thioperamide, clobenpropit and ciproxifan. Addition of these s
Autor:
LoriAnn M. Ruck, Robert W. Egan, John C. Anthes, Cuss Francis M, Stephen Eckel, John A. Hey, Charles A. Rizzo
Publikováno v:
Life Sciences. 68:2825-2834
Mast cell histamine (HA) and cysteinyl leukotrienes (CysLT) account for most of the early phase bronchospasm in asthma. However, activation of the smooth muscle CysLT1-receptor plays a major role in asthmatic bronchospasms. CysLT-receptor antagonists
Autor:
Charles A. Rizzo, Charles G. Garlisi, Michael Minnicozzi, Angela Falcone, John A. Hey, Robert W. Egan, Theresa M. Paster, Howard Jones, M. Motasim Billah, Xiomara Fernandez, Shelby P. Umland
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 17:642-651
Asthma is characterized by acute episodes of nonspecific airway hyperreactivity and chronic pulmonary inflammation exacerbated by stimuli including allergen exposure. In order to reproduce the physiologic and immunologic responses that occur in asthm