Zobrazeno 1 - 10
of 352
pro vyhledávání: '"Charles A. Parkos"'
Autor:
Arturo Raya-Sandino, Kristen M. Lozada-Soto, Nandhini Rajagopal, Vicky Garcia-Hernandez, Anny-Claude Luissint, Jennifer C. Brazil, Guiying Cui, Michael Koval, Charles A. Parkos, Shikha Nangia, Asma Nusrat
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Claudin family tight junction proteins form charge- and size-selective paracellular channels that regulate epithelial barrier function. In the gastrointestinal tract, barrier heterogeneity is attributed to differential claudin expression. He
Externí odkaz:
https://doaj.org/article/e6dc802f5ea44a33acc5626c32b09f7b
Autor:
Veronica Azcutia, Matthias Kelm, Dylan Fink, Richard D. Cummings, Asma Nusrat, Charles A. Parkos, Jennifer C. Brazil
Publikováno v:
JCI Insight, Vol 8, Iss 5 (2023)
Polymorphonuclear neutrophils (PMNs) play a critical role in clearing invading microbes and promoting tissue repair following infection/injury. However, dysregulated PMN trafficking and associated tissue damage is pathognomonic of numerous inflammato
Externí odkaz:
https://doaj.org/article/d6fb41fb7b8046a2aa6d914ce6d586d8
Autor:
Shusaku Hayashi, Chithra K. Muraleedharan, Makito Oku, Sunil Tomar, Simon P. Hogan, Miguel Quiros, Charles A. Parkos, Asma Nusrat
Publikováno v:
JCI Insight, Vol 7, Iss 23 (2022)
Acute and chronic intestinal inflammation is associated with epithelial damage, resulting in mucosal wounds in the forms of erosions and ulcers in the intestinal tract. Intestinal epithelial cells (IECs) and immune cells in the wound milieu secrete c
Externí odkaz:
https://doaj.org/article/175ef08d9ea04245a6569f22c28864f0
Autor:
Shuling Fan, Kevin Boerner, Chithra K. Muraleedharan, Asma Nusrat, Miguel Quiros, Charles A. Parkos
Publikováno v:
JCI Insight, Vol 7, Iss 17 (2022)
Junctional adhesion molecule-A (JAM-A) is expressed in several cell types, including epithelial and endothelial cells, as well as some leukocytes. In intestinal epithelial cells (IEC), JAM-A localizes to cell junctions and plays a role in regulating
Externí odkaz:
https://doaj.org/article/9146c51e646e4f299747b38e13c56371
Autor:
Nathan J. Klingensmith, Katherine T. Fay, David A. Swift, Julia M.R. Bazzano, John D. Lyons, Ching-wen Chen, Mei Meng, Kimberly M. Ramonell, Zhe Liang, Eileen M. Burd, Charles A. Parkos, Mandy L. Ford, Craig M. Coopersmith
Publikováno v:
JCI Insight, Vol 7, Iss 16 (2022)
Expression of the tight junction–associated protein junctional adhesion molecule-A (JAM-A) is increased in sepsis, although the significance of this is unknown. Here, we show that septic JAM-A –/– mice have increased gut permeability, yet parad
Externí odkaz:
https://doaj.org/article/fbfc530dda6d4b10a3967d7271e7af69
Autor:
Shuling Fan, Michelle Sydney Smith, Justin Keeney, Monique N. O’Leary, Asma Nusrat, Charles A. Parkos
Publikováno v:
iScience, Vol 25, Iss 5, Pp 104316- (2022)
Summary: JAM-A is a tight-junction-associated protein that contributes to regulation of intestinal homeostasis. We report that JAM-A interacts with NF2 and LATS1, functioning as an initiator of the Hippo signaling pathway, well-known for regulation o
Externí odkaz:
https://doaj.org/article/2c86e81a490740ea952a90d3452f9eb0
Autor:
Anu Autio, Huan Wang, Francisco Velázquez, Gail Newton, Charles A. Parkos, Pablo Engel, Daniel Engelbertsen, Andrew H. Lichtman, Francis W. Luscinskas
Publikováno v:
PLoS ONE, Vol 17, Iss 4 (2022)
The SIRPα-CD47 axis plays an important role in T cell recruitment to sites of immune reaction and inflammation but its role in T cell antigen priming is incompletely understood. Employing OTII TCR transgenic mice bred to Cd47-/- (Cd47KO) or SKI mice
Externí odkaz:
https://doaj.org/article/b3c42c1c18214cdab9a0768dbaa52277
Autor:
Michelle Reed, Anny-Claude Luissint, Veronica Azcutia, Shuling Fan, Monique N. O’Leary, Miguel Quiros, Jennifer Brazil, Asma Nusrat, Charles A. Parkos
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
The role of the transmembrane glycoprotein CD47 in healing injured intestinal mucosa is unclear. Here, the authors show that selective loss of CD47 in the murine intestinal epithelium results in defective mucosal repair after colonic wounding, with s
Externí odkaz:
https://doaj.org/article/f0ca1f6c382d4838b22e30bc6b39240c
Autor:
Zhengqi Wang, Tamisha Y. Vaughan, Wandi Zhu, Yuhong Chen, Guoping Fu, Magdalena Medrzycki, Hikaru Nishio, Silvia T. Bunting, Pamela A. Hankey-Giblin, Asma Nusrat, Charles A. Parkos, Demin Wang, Renren Wen, Kevin D. Bunting
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Inflammatory Bowel Disease (IBD) is a multi-factorial chronic inflammation of the gastrointestinal tract prognostically linked to CD8+ T-cells, but little is known about their mechanism of activation during initiation of colitis. Here, Grb2-associate
Externí odkaz:
https://doaj.org/article/2a6344e317274854947962fedcc832e3
Autor:
Laura Salinas-Muñoz, Raúl Campos-Fernández, Enrique Mercader, Irene Olivera-Valle, Carlota Fernández-Pacheco, Lara Matilla, Julio García-Bordas, Jennifer C. Brazil, Charles A. Parkos, Fernando Asensio, Maria A. Muñoz-Fernández, Andrés Hidalgo, Paloma Sánchez-Mateos, Rafael Samaniego, Miguel Relloso
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Estradiol-based therapies predispose women to vaginal infections. Moreover, it has long been known that neutrophils are absent from the vaginal lumen during the ovulatory phase (high estradiol). However, the mechanisms that regulate neutrophil influx
Externí odkaz:
https://doaj.org/article/cab3ab8e0d8d4f35ac414490076dd873