Výsledky vyhledávání - "Charles A. Minor"

Design, Synthesis, and Evaluation of Naphthalene-Sulfonamide Antagonists of Human CCR8

Publikováno v: Journal of Medicinal Chemistry. 50:566-584

The design, synthesis, and structure-activity relationship development of naphthalene-derived human CCR8 antagonists is described. In vitro binding assay results of these investigations are reported, critical interactions of the antagonists with CCR8

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81ece8a43fb824560f99d9d32c158515
https://doi.org/10.1021/jm061118e

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Substrate-Based Design of the First Class of Angiotensin-Converting Enzyme-Related Carboxypeptidase (ACE2) Inhibitors

Autor: Timothy D. Ocain, Alexandra E. Gould, Natalie A. Dales, James Brown, Emily F. Calderwood, James M. Gavin, Charles A. Minor, Bing Guan, Chad S Vickers, Virendar K. Kaushik, Paul Hales, Michael A. Patane, Peter J. Tummino, Michael Stewart

Publikováno v: Journal of the American Chemical Society. 124:11852-11853

Angiotensin-converting enzyme-related carboxypeptidase (ACE2) is a recently identified zinc metalloprotease with carboxypeptidase activity that was identified using our genomics platform. We implemented a rational design approach to identify potent a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0ae8e267715c9ef3c7da7ac60af86b2
https://doi.org/10.1021/ja0277226

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Staphylococcal Pneumonia and Its Complications: A Surgical Emergency in Infants and Children

Autor: Charles L. Minor, Elias A. Moschakis

Publikováno v: Clinical Pediatrics. 1:111-116

The records of 50 patients treated at Children's Hospital of Philadelphia for staphylococcal pneumonia and its complications have been reviewed. Nine of these patients died despite vigorous treatment. This is a highly fatal disease, especially in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c6e1052569693bb492a4ffa4ab5134fc
https://doi.org/10.1177/000992286200100211

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Staphylococcal Pneumonia and Its Complications

Autor: Elias A. Moschakis, Charles L. Minor

Publikováno v: Clinical Pediatrics. 1:111-116

The records of 50 patients treated at Children's Hospital of Philadelphia for staphylococcal pneumonia and its complications have been reviewed. Nine of these patients died despite vigorous treatme...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8a140a1b6f50ae1be3a3a9d16ace2a48
https://doi.org/10.1177/000992286200100122

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EXPERIENCES WITH THE MANAGEMENT OF PLEXIFORM NEUROFIBROMA

Autor: Charles L. Minor, C. Everett Koop

Publikováno v: Pediatrics. 24:482-488

Plexiform neurofibroma is a relatively uncommon manifestation of diffuse neurofibromatosis and is characterized by its unique gross appearance. Because of its tendency to involve peripheral nerves centripetally it must be vigorously treated surgicall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::15dce910ca99e7ec85bd6346533f2eb5
https://doi.org/10.1542/peds.24.3.482

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