Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Charles A. Kunsch"'
Publikováno v:
Inflammation Research. 58:513-521
To investigate the effects of sulforaphane on endothelial inflammatory gene expression in endothelial cells.Human aortic endothelial cells were used in the study.One-hour pretreatment of endothelial cells (EC) with sulforaphane (1-4 muM) suppressed T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ed57dbdc8f443b883e13e6cfed396bf
https://doi.org/10.1007/s00011-009-0017-7
https://doi.org/10.1007/s00011-009-0017-7
Autor:
Charles A. Kunsch, Heidi G. Stahl, Lori A. Ocker, Clement J. Purcell, Robert L. Buchanan, Dana W. Wiseman
Publikováno v:
Journal of Food Safety. 8:127-138
Earlier work characterizing the effects of glucose analogs on growth and aflatoxin production by Aspergillus parasiticus was expanded by assessing the effects of β-methylglucose (βMG), 3-0-methylglucose (3MG) and thioglucose (TG). As sole carbon so
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::699f520295c6eaaed0a7b63ebaaf3265
https://doi.org/10.1111/j.1745-4565.1986.tb00558.x
https://doi.org/10.1111/j.1745-4565.1986.tb00558.x
Autor:
Zhihong Ye, Charles Q. Meng, Kimberly J. Worsencroft, James A. Sikorski, Randy B. Howard, Ki-Ling Suen, Martin A. Wasserman, Liming Ni, Jason W. Skudlarek, Jacob E. Simpson, Cynthia L. Sundell, Charles A. Kunsch, Amy Souder, M. David Weingarten, Elaine M. Marino
Publikováno v:
Journal of Medicinal Chemistry. 50:1304-1315
Starting from a simple chalcone template, structure-activity relationship (SAR) studies led to a series of carboxylated, heteroaryl-substituted chalcone derivatives as novel, potent inhibitors of vascular cell adhesion molecule-1 (VCAM-1) expression.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5756878f29e82e8d43f25c4437d306cc
https://doi.org/10.1021/jm0614230
https://doi.org/10.1021/jm0614230
Publikováno v:
Journal of Food Science. 50:304-307
Cooked corned beef made with normal (ca.2.5%) or a reduced (ca.1.5%) level of salt were inoculated with either clostridial spores or with staphylococci and incubated at temperatures ranging from 5 - 30°C. Growth of indigenous microflora, staphylococ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc2ebb9fcbed8e7f0c5978e6a7802df8
https://doi.org/10.1111/j.1365-2621.1985.tb13387.x
https://doi.org/10.1111/j.1365-2621.1985.tb13387.x
Publikováno v:
Current Medicinal Chemistry-Immunology, Endocrine & Metabolic Agents. 5:249-258
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::269e57847ec4d1e215ad6072fe440f23
https://doi.org/10.2174/1568013054022490
https://doi.org/10.2174/1568013054022490
Autor:
Martin A. Wasserman, Geraldine Dodd, Lyn K. Olliff, Charles A. Kunsch, J. Daniel Piper, Kanika S. Karu, Charles Q. Meng, Elaine M. Marino, James A. Sikorski, Jayraz Luchoomun, Suzanne T. Thomas, Xi-Lin Chen, Anne M. Whalen, Ki-Ling Suen, Fei-Hua Qiu, Patricia K. Somers, Cynthia L. Sundell
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 313:492-501
The pathogenesis of chronic inflammatory diseases, including rheumatoid arthritis, is regulated, at least in part, by modulation of oxidation-reduction (redox) homeostasis and the expression of redox-sensitive inflammatory genes including adhesion mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62b1f89af71a95b6ae5f85f45de1cb7b
https://doi.org/10.1124/jpet.104.080804
https://doi.org/10.1124/jpet.104.080804
Autor:
Fei-Hua Qiu, Janice Y. Grey, Russell M. Medford, Xi-Lin Chen, Suzanne T. Thomas, Martin A. Wasserman, Charles A. Kunsch
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 287:H1452-H1458
Atherosclerosis is a focal inflammatory disease and preferentially occurs in areas of low fluid shear stress and oscillatory flow, whereas the risk of atherosclerosis is decreased in regions of high fluid shear stress and steady laminar flow. Sphingo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c76e9db1e9dd352a4361d3857a96aea
https://doi.org/10.1152/ajpheart.01101.2003
https://doi.org/10.1152/ajpheart.01101.2003
Discovery of novel heteroaryl-substituted chalcones as inhibitors of TNF-α-induced VCAM-1 expression
Autor:
Jason W. Skudlarek, Martin A. Wasserman, Jacob E. Simpson, James A. Sikorski, Liming Ni, Kimberly J. Worsencroft, Hotema Martha R, Ki-Ling Suen, X.Sharon Zheng, Charles A. Kunsch, Zhihong Ye, Russell R. Hill, Elaine M. Marino, Lee K. Hoong, M. David Weingarten, Joshua M. Gilmore, Charles Q. Meng
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:1513-1517
Novel chalcone derivatives have been discovered as potent inhibitors of TNF-α-induced VCAM-1 expression. Thienyl or benzothienyl substitution at the meta-position of ring B helps boost potency while large substitution at the para-position on ring B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fccac86680b3969958f87939056d433
https://doi.org/10.1016/j.bmcl.2004.01.021
https://doi.org/10.1016/j.bmcl.2004.01.021
Autor:
Jayraz Luchoomun, Martin A. Wasserman, Charles A. Kunsch, Russell M. Medford, Uday Saxena, Richard F. Arrendale, Lynda K. Olliff, Leigh B. Saint, Janice Y. Grey
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 308:820-829
Atherosclerosis is a disease of oxidative stress and inflammation. AGI-1067 [butanedioic acid, mono[4-[[1-[[3,5-bis(1,1-dimethylethyl)-4-,hydroxyphenyl]thio]-1-methylethyl]thio]-2,6-bis (1,1-dimethylethyl)phenyl] ester] is a metabolically stable deri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fa0b74b5385c38a77226b53a3864a55
https://doi.org/10.1124/jpet.103.059733
https://doi.org/10.1124/jpet.103.059733
Autor:
Janice Y. Grey, Suzanne T. Thomas, Anjali S. Rao, Signe E. Varner, Russell M. Medford, Anil K. Jaiswal, Xi-Lin Chen, Martin A. Wasserman, Charles A. Kunsch, Christopher K. Cook
Publikováno v:
Journal of Biological Chemistry. 278:703-711
Atherosclerotic lesions preferentially develop in areas of the vasculature exposed to nonlaminar blood flow and low fluid shear stress, whereas laminar flow and high fluid shear stress are athero-protective. We have identified a set of genes includin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ad279ef70278b0e4309ea2dd467dd25
https://doi.org/10.1074/jbc.m203161200
https://doi.org/10.1074/jbc.m203161200