Zobrazeno 1 - 10
of 904
pro vyhledávání: '"Charles A. Jones"'
Publikováno v:
iScience, Vol 27, Iss 12, Pp 111326- (2024)
Summary: Health equity is a concept that has gained increasing attention and relevance in the context of the COVID-19 pandemic, which has exposed and exacerbated the health disparities and inequities among different population groups in the United St
Externí odkaz:
https://doaj.org/article/9d3356d6b25c45e0ae53cf86cf56de73
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110257- (2024)
Summary: The COVID-19 pandemic has exposed and exacerbated the persistent racial and ethnic health disparities in the United States. The pandemic has also had profound spillover effects on other aspects of health and wellbeing, such as mental health,
Externí odkaz:
https://doaj.org/article/c5bfe0e93b574e1b85ef9165f6aaede1
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-11 (2024)
Abstract Amidst the backdrop of the COVID-19 pandemic, vaccine innovation has garnered significant attention, but this field was already on the cusp of a groundbreaking renaissance. Propelling these advancements are scientific and technological break
Externí odkaz:
https://doaj.org/article/eacbe4bd9ef24999867befe83e687ce4
Autor:
Charles H. Jones, John R. Androsavich, Nina So, Matthew P. Jenkins, Derek MacCormack, Andrew Prigodich, Verna Welch, Jane M. True, Mikael Dolsten
Publikováno v:
npj Genomic Medicine, Vol 9, Iss 1, Pp 1-14 (2024)
Abstract In the past decade, RNA therapeutics have gone from being a promising concept to one of the most exciting frontiers in healthcare and pharmaceuticals. The field is now entering what many call a renaissance or “RNAissance” which is being
Externí odkaz:
https://doaj.org/article/29d29f5f45c04de3b82b3bce6a3a0711
Publikováno v:
npj Systems Biology and Applications, Vol 9, Iss 1, Pp 1-10 (2023)
Abstract Recent global events have drawn into focus the diversity of options for combatting disease across a spectrum of prophylactic and therapeutic approaches. The recent success of the mRNA-based COVID-19 vaccines has paved the way for RNA-based t
Externí odkaz:
https://doaj.org/article/972a3f707f6140c4ad753f97f0c16fd7
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-12 (2023)
Abstract The COVID-19 pandemic was met with rapid, unprecedented global collaboration and action. Even still, the public health, societal, and economic impact may be felt for years to come. The risk of another pandemic occurring in the next few decad
Externí odkaz:
https://doaj.org/article/990527f051604d86b3bc9bef5a854f56
Autor:
Charles Bayly-Jones, Bill H. T. Ho, Corinna Lau, Eleanor W. W. Leung, Laura D’Andrea, Christopher J. Lupton, Susan M. Ekkel, Hariprasad Venugopal, James C. Whisstock, Tom E. Mollnes, Bradley A. Spicer, Michelle A. Dunstone
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-11 (2023)
The cryo-EM structure of monoclonal antibody aE11 bound to polyC9 reveals that the binding site within the Membrane Attack Complex is a quaternary discontinuous epitope formed by two separate surfaces of the oligomeric C9 periphery.
Externí odkaz:
https://doaj.org/article/96ef9aa75dd84880b13fa08f60261470
Autor:
Charles Bayly-Jones, Christopher J. Lupton, Claudia Fritz, Hariprasad Venugopal, Daniel Ramsbeck, Michael Wermann, Christian Jäger, Alex de Marco, Stephan Schilling, Dagmar Schlenzig, James C. Whisstock
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Meprin α is a proteolytic regulator of the extracellular matrix that forms enormous oligomeric filaments of unknown purpose. Here, the authors determine by cryo-EM the structural basis of the meprin supercoiled filament and further characterise a sm
Externí odkaz:
https://doaj.org/article/38630ad799064ddaba5722e41c9934b6
Autor:
Conall McGuinness, James C Walsh, Charles Bayly-Jones, Michelle A Dunstone, Michelle P Christie, Craig J Morton, Michael W Parker, Till Böcking
Publikováno v:
eLife, Vol 11 (2022)
The cholesterol-dependent cytolysin perfringolysin O (PFO) is secreted by Clostridium perfringens as a bacterial virulence factor able to form giant ring-shaped pores that perforate and ultimately lyse mammalian cell membranes. To resolve the kinetic
Externí odkaz:
https://doaj.org/article/9c52c20469604be898a9fcf4065fd2d3
Autor:
Charles Bayly-Jones, James C Whisstock
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 3, p e1009930 (2022)
Protein structure fundamentally underpins the function and processes of numerous biological systems. Fold recognition algorithms offer a sensitive and robust tool to detect structural, and thereby functional, similarities between distantly related ho
Externí odkaz:
https://doaj.org/article/768cbd929ad04d3091f17e1ac45822ec