Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Charles A. C. Williams"'
Autor:
María Ángeles Marqués-Torrejón, Charles A. C. Williams, Benjamin Southgate, Neza Alfazema, Melanie P. Clements, Claudia Garcia-Diaz, Carla Blin, Nerea Arranz-Emparan, Jane Fraser, Noor Gammoh, Simona Parrinello, Steven M. Pollard
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
How neural stem cells can transition between states of proliferation and quiescence is unclear. Here, the authors identify Lrig1 as a specific marker for the primed quiescent state and demonstrate that Lrig1 maintains cells in a quiescent state via m
Externí odkaz:
https://doaj.org/article/3e0ce24ca18642ab920706ba35de6dae
Publikováno v:
Parkinson's Disease, Vol 2015 (2015)
We provide an insight into the role Drosophila has played in elucidating neurophysiological perturbations associated with Parkinson’s disease- (PD-) related genes. Synaptic signalling deficits are observed in motor, central, and sensory systems. Gi
Externí odkaz:
https://doaj.org/article/f4088b78b2734b019d65fa3a66440ec1
Publikováno v:
Williams, C A C, Soufi, A & Pollard, S M 2019, ' Post-translational modification of SOX family proteins : Key biochemical targets in cancer? ', seminars in cancer biology . https://doi.org/10.1016/j.semcancer.2019.09.009
Seminars in Cancer Biology
Seminars in Cancer Biology
Sox proteins are a family of lineage-associated transcription factors. They regulate expression of genes involved in control of self-renewal and multipotency in both developmental and adult stem cells. Overexpression of Sox proteins is frequently obs
Autor:
Charles A. C. Williams, Diana O. Rios-Szwed, Helen A. Brown, Houjiang Zhou, Greg M. Findlay, Marios P. Stavridis, Saria Mansoor, Julien Peltier, Jose M. Lizcano, Matthias Trost, Robert Gourlay, Liam McMulkin, Rosalia Fernandez-Alonso, Rachel Toth, Nora Diéguez-Martínez
Publikováno v:
Biochemical Journal
The ERK5 MAP kinase signalling pathway drives transcription of naïve pluripotency genes in mouse Embryonic Stem Cells (mESCs). However, how ERK5 impacts on other aspects of mESC biology has not been investigated. Here, we employ quantitative proteom
Autor:
Melanie Clements, Neza Alfazema, Noor Gammoh, Charles A. C. Williams, Claudia Garcia-Diaz, Jane Fraser, Nerea Arranz-Emparan, Carla Blin, Maria Angeles Marques-Torrejon, Steven M. Pollard, Benjamin Southgate, Simona Parrinello
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Marques, M A, Williams, C, Southgate, B, Alfazema, N, Clements, M, Garcia-Diaz, C, Blin, C, Arranz Emparan, N, Fraser, J, Gammoh, N, Parrinello, S & Pollard, S M 2021, ' LRIG1 is a gatekeeper to exit from quiescence in adult neural stem cells ', Nature Communications . https://doi.org/10.1038/s41467-021-22813-w
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Marques, M A, Williams, C, Southgate, B, Alfazema, N, Clements, M, Garcia-Diaz, C, Blin, C, Arranz Emparan, N, Fraser, J, Gammoh, N, Parrinello, S & Pollard, S M 2021, ' LRIG1 is a gatekeeper to exit from quiescence in adult neural stem cells ', Nature Communications . https://doi.org/10.1038/s41467-021-22813-w
Adult neural stem cells (NSCs) must tightly regulate quiescence and proliferation. Single-cell analysis has suggested a continuum of cell states as NSCs exit quiescence. Here we capture and characterize in vitro primed quiescent NSCs and identify LRI
Autor:
Liam McMulkin, Charles A. C. Williams, Rosalia Fernandez-Alonso, Houjiang Zhou, Robert Gourlay, Jose M. Lizcano, Rachel Toth, Greg M. Findlay, Saria Mansoor, Diana O. Rios-Szwed, Matthias Trost, Nora Diéguez-Martínez, Marios P. Stavridis, Julien Peltier, Helen A. Brown
SummaryThe ERK5 MAP kinase signalling pathway drives transcription of naïve pluripotency genes in mouse Embryonic Stem Cells (mESCs). However, how ERK5 impacts on other aspects of mESC biology has not been investigated. Here, we employ quantitative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80ad83f3a3e983fe2fc872656dd61f88
https://doi.org/10.1101/2021.03.29.435803
https://doi.org/10.1101/2021.03.29.435803
Autor:
Simon R. Tomlinson, Kirsty M. Ferguson, Charles A. C. Williams, Richard A. Anderson, Neza Alfazema, Leanne Bradley, Benjamin Southgate, Alex von Kriegsheim, Maria Angeles Marques-Torrejon, Faye L Robertson, Gillian Morrison, Vivien Grant, Steven M. Pollard, Carla Blin, Jimi Wills, James Ashmore, Raul Bardini Bressan
Publikováno v:
Bressan, R B, Southgate, B, Ferguson, K M, Blin, C, Grant, V, Alfazema, N, Wills, J C, Marques, M A, Morrison, G M, Ashmore, J, Robertson, F, Williams, C A C, Bradley, L, von Kriegsheim, A, Anderson, R A, Tomlinson, S R & Pollard, S M 2021, ' Regional identity of human neural stem cells determines oncogenic responses to histone H3.3 mutants ', Cell Stem Cell, vol. 28, no. 5, pp. 877-893.e9 . https://doi.org/10.1016/j.stem.2021.01.016
Point mutations within the histone H3.3 are frequent in aggressive childhood brain tumors known as pediatric high-grade gliomas (pHGGs). Intriguingly, distinct mutations arise in discrete anatomical regions: H3.3-G34R within the forebrain and H3.3-K2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b62ac005e0806ba597ff012910e68b7
https://www.pure.ed.ac.uk/ws/files/253710541/mmc4.pdf
https://www.pure.ed.ac.uk/ws/files/253710541/mmc4.pdf
Publikováno v:
Journal of Visualized Experiments : JoVE
Embryonic stem cells (ESCs) can self-renew or differentiate into all cell types, a phenomenon known as pluripotency. Distinct pluripotent states have been described, termed "naïve" and "primed" pluripotency. The mechanisms that control naïve-primed
Publikováno v:
Journal of molecular biology. 429(10)
Post-translational modification of proteins by phosphorylation plays a key role in regulating all aspects of eukaryotic biology. Embryonic stem cell (ESC) pluripotency, defined as the ability to differentiate into all cell types in the adult body, is
Publikováno v:
Parkinson's Disease
We provide an insight into the role Drosophila has played in elucidating neurophysiological perturbations associated with Parkinson's disease- (PD-) related genes. Synaptic signalling deficits are observed in motor, central, and sensory systems. Give