Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Charles A. Brunette"'
Autor:
Charles A. Brunette, Elizabeth J. Harris, Ashley A. Antwi, Amy A. Lemke, Benjamin J. Kerman, Jason L. Vassy
Publikováno v:
Data in Brief, Vol 52, Iss , Pp 109930- (2024)
Genetic risk scores (GRS) are an emerging and rapidly evolving genomic medicine innovation that may contribute to more precise risk stratification for disease prevention. Inclusion of GRS in routine medical care is imminent, and understanding how phy
Externí odkaz:
https://doaj.org/article/f4ddc31fbe61498a9d3f6f6d6795ba9d
Autor:
Charles A. Brunette, Stephen J. Miller, Nilla Majahalme, Cynthia Hau, Lauren MacMullen, Sanjay Advani, Sophie A. Ludin, Andrew J. Zimolzak, Jason L. Vassy
Publikováno v:
Clinical and Translational Science, Vol 13, Iss 2, Pp 381-390 (2020)
Pragmatic clinical trials (PCTs) have an established presence in clinical research and yet have only recently garnered attention within the landscape of genomic medicine. Using the PRagmatic‐Explanatory Continuum Indicator Summary 2 (PRECIS‐2) as
Externí odkaz:
https://doaj.org/article/b2a08f7cf67847e58fc14327932b5475
Autor:
Charles A. Brunette, Olivia M. Dong, Jason L. Vassy, Morgan E. Danowski, Nicholas Alexander, Ashley A. Antwi, Kurt D. Christensen
Publikováno v:
Journal of Personalized Medicine, Vol 11, Iss 11, p 1123 (2021)
There is a well-validated association between SLCO1B1 (rs4149056) and statin-associated muscle symptoms (SAMS). Preemptive SLCO1B1 pharmacogenetic (PGx) testing may diminish the incidence of SAMS by identifying individuals with increased genetic risk
Externí odkaz:
https://doaj.org/article/bce280f5a3324b0bba6cd0a0da6a1f6f
Autor:
Limin Hao, Peter Kraft, Gabriel F. Berriz, Elizabeth D. Hynes, Christopher Koch, Prathik Korategere V Kumar, Shruti S. Parpattedar, Marcie Steeves, Wanfeng Yu, Ashley A. Antwi, Charles A. Brunette, Morgan Danowski, Manish K. Gala, Robert C. Green, Natalie E. Jones, Anna C. F. Lewis, Steven A. Lubitz, Pradeep Natarajan, Jason L. Vassy, Matthew S. Lebo
Publikováno v:
Nature Medicine. 28:1006-1013
Implementation of polygenic risk scores (PRS) may improve disease prevention and management but poses several challenges: the construction of clinically valid assays, interpretation for individual patients, and the development of clinical workflows a
Autor:
Jason L. Vassy, Benjamin J. Kerman, Elizabeth J. Harris, Amy A. Lemke, Marla L. Clayman, Ashley A. Antwi, Katharine MacIsaac, Thomas Yi, Charles A. Brunette
Publikováno v:
European Journal of Human Genetics.
Autor:
Charles A. Brunette, Jason L. Vassy
Publikováno v:
Pharmacogenomics. 22:649-656
Autor:
Jason L. Vassy, Benjamin J. Kerman, Elizabeth J. Harris, Amy A. Lemke, Marla L. Clayman, Ashley A. Antwi, Katharine MacIsaac, Thomas Yi, Charles A. Brunette
BackgroundClinical implementation of polygenic risk scores (PRS) for precision prevention depends on the utility and barriers primary care physicians (PCPs) perceive to their use.MethodsAn online survey asked PCPs in a national database about the cli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e884bcf5f609754ca0fd2fb64865f057
https://doi.org/10.1101/2022.09.29.22280488
https://doi.org/10.1101/2022.09.29.22280488
Autor:
Benjamin J. Kerman, Charles A. Brunette, Elizabeth J. Harris, Ashley A. Antwi, Amy A. Lemke, Jason L. Vassy
Publikováno v:
Genetics in Medicine. 25:100800
Autor:
Andrew J. Zimolzak, Charles A. Brunette, Cynthia Hau, Sophie A. Ludin, Jason L. Vassy, Lauren MacMullen, Sanjay Advani, Stephen J. Miller, Nilla Majahalme
Publikováno v:
Clinical and Translational Science
Clinical and Translational Science, Vol 13, Iss 2, Pp 381-390 (2020)
Clinical and Translational Science, Vol 13, Iss 2, Pp 381-390 (2020)
Pragmatic clinical trials (PCTs) have an established presence in clinical research and yet have only recently garnered attention within the landscape of genomic medicine. Using the PRagmatic‐Explanatory Continuum Indicator Summary 2 (PRECIS‐2) as
Autor:
Marcie A. Steeves, Prathik K. Vijay Kumar, Shruti Parpattedar, Ashley Antwi, Robert C. Green, Charles A. Brunette, Limin Hao, Manish Gala, Matthew S. Lebo, Elizabeth Hynes, Peter Kraft, Steven Lubitz, Christopher Koch, Morgan Danowski, Wanfeng Yu, Jason L. Vassy, Gabriel Berriz, Pradeep Natajaran, Anna C. F. Lewis, Natalie Jones
Implementation of polygenic risk scores (PRS) may improve disease prevention and management but requires the construction and validation of clinical assays, interpretation, and reporting pipelines. We developed a clinical genotype array-based assay f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::469bda8330fcaf27af08fedb55ca4477
https://doi.org/10.21203/rs.3.rs-743779/v1
https://doi.org/10.21203/rs.3.rs-743779/v1