Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Charles A. Berdan"'
Autor:
Ofer Moldavski, Peter-James H. Zushin, Charles A. Berdan, Robert J. Van Eijkeren, Xuntian Jiang, Mingxing Qian, Daniel S. Ory, Douglas F. Covey, Daniel K. Nomura, Andreas Stahl, Ethan J. Weiss, Roberto Zoncu
Publikováno v:
Journal of Lipid Research, Vol 62, Iss , Pp 100051- (2021)
Oxysterols are oxidized derivatives of cholesterol that play regulatory roles in lipid biosynthesis and homeostasis. How oxysterol signaling coordinates different lipid classes such as sterols and triglycerides remains incompletely understood. Here,
Externí odkaz:
https://doaj.org/article/486839a449b44a929c2b2c5b68c4be5b
Publikováno v:
mSphere, Vol 4, Iss 6 (2019)
ABSTRACT Gram-negative bacteria in the order Rickettsiales have an obligate intracellular growth requirement, and some species cause human diseases such as typhus and spotted fever. The bacteria have evolved a dependence on essential nutrients and me
Externí odkaz:
https://doaj.org/article/53f1d931ef4c45f28b2d436f73249013
Publikováno v:
mSphere, Vol 4, Iss 6 (2019)
Externí odkaz:
https://doaj.org/article/efeeeb2772f44258833317c5baa5968d
Autor:
Matthew A. Davis, Vivian Yaci Yu, Beverly Fu, Miao Wen, Edward J. Koleski, Joshua Silverman, Charles A. Berdan, Daniel K. Nomura, Michelle C. Y. Chang
Living organisms carry out a wide range of remarkable functions, including the synthesis of thousands of simple and complex chemical structures for cellular growth and maintenance. The manipulation of this reaction network has allowed for the genetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2af3a115deac6a58ac575e8f0cd073a4
https://doi.org/10.1101/2023.01.09.523327
https://doi.org/10.1101/2023.01.09.523327
Autor:
Daniel K. Nomura, Roberto Zoncu, Hijai R. Shin, Xuntian Jiang, Justin Zhang, Charles A. Berdan, Daniel S. Ory, Oliver B. Davis, Chun Yan Lim, Jessica L. Counihan
Publikováno v:
Nature cell biology
Cholesterol activates the master growth regulator, mTORC1 kinase, by promoting its recruitment to the surface of lysosomes by the Rag guanosine triphosphatases (GTPases). The mechanisms that regulate lysosomal cholesterol content to enable mTORC1 sig
Autor:
Carl C. Ward, James A. Olzmann, Roberto Zoncu, Charles A. Berdan, Hijai R. Shin, Clive Yik-Sham Chung, Daniel K. Nomura, Breanna Ford
Publikováno v:
Nature chemical biology, vol 15, iss 8
Nature chemical biology
Nature chemical biology
Autophagy is a lysosomal degradation pathway that eliminates aggregated proteins and damaged organelles to maintain cellular homeostasis. A major route for activating autophagy involves inhibition of the mTORC1 kinase, but current mTORC1-targeting co
Autor:
Daniel S. Ory, Peter-James H. Zushin, Xuntian Jiang, Mingxing Qian, Daniel K. Nomura, Ofer Moldavski, Ethan J. Weiss, Charles A. Berdan, Robert J. van Eijkeren, Douglas F. Covey, Andreas Stahl, Roberto Zoncu
Oxysterols are oxidized derivatives of cholesterol that play signaling roles in lipid biosynthesis and homeostasis. Here we show that 4β-hydroxycholesterol (4β-HC), a liver and serum abundant oxysterol of poorly defined function, is a potent and se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e8c5eb8c157fef4d7e3682a5e26fd3d
https://doi.org/10.1101/2020.08.20.256487
https://doi.org/10.1101/2020.08.20.256487
Publikováno v:
mSphere, vol 4, iss 6
mSphere, Vol 4, Iss 6 (2019)
mSphere, Vol 4, Iss 6, p e00536-19 (2019)
mSphere, Vol 4, Iss 6 (2019)
mSphere, Vol 4, Iss 6, p e00536-19 (2019)
Gram-negative bacteria in the order Rickettsiales have an obligate intracellular growth requirement, and some species cause human diseases such as typhus and spotted fever. The bacteria have evolved a dependence on essential nutrients and metabolites
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f262f0ec1faf93babe4cbd12dba98cf
https://escholarship.org/uc/item/8hd582kn
https://escholarship.org/uc/item/8hd582kn
Autor:
Milton To, James A. Olzmann, Xirui Hu, Haley S. Lehtola, Thomas J. Maimone, Tucker R. Huffman, Yana Petri, Daniel K. Nomura, Chad R. Altobelli, Sasha G. Demeulenaere, Charles A. Berdan, Raymond Ho
Publikováno v:
Cell chemical biology, vol 26, iss 7
Cell Chem Biol
Cell Chem Biol
Parthenolide, a natural product from the feverfew plant and member of the large family of sesquiterpene lactones, exerts multiple biological and therapeutic activities including anti-inflammatory and anti-cancer effects. Herein, we further study part
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b7018a4310df986ef7670c3d310091f
https://escholarship.org/uc/item/9b10s9jq
https://escholarship.org/uc/item/9b10s9jq
Gram-negative bacteria in the order Rickettsiales are obligate intracellular parasites that cause human diseases such typhus and spotted fever. They have evolved a dependence on essential nutrients and metabolites from the host cell as a consequence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6df501262c199940afd4bf28ccd28ae