Výsledky vyhledávání - "Charles A. Alt"

How to Convert a Walk-in Hood into a Manufacturing Facility: Demonstration of a Continuous, High-Temperature Cyclization to Process Solids in Flow

Autor: Kevin P. Cole, Charles A. Alt, Jennifer McClary Groh, Timothy D. White, Martin D. Johnson, Richard D. Miller

Publikováno v: Organic Process Research & Development. 18:1482-1491

An intramolecular thermal cyclization protocol was developed in a flow reactor to take advantage of the high pressures and temperatures that are easily obtained in small scale autoclave reactors that have been modified to handle slurries. This reacto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6a96b1997ee7f6f71f0c9faf407c5cb4
https://doi.org/10.1021/op500239f

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Synthesis of Methyl 7,9-Dimethyl-5-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carboxylate and Its Analogues

Autor: Charles A. Alt, Jeremy T. Spitler, Sathish K. Boini, Eric D. Moher, Chad E. Hadden, Scott Alan Frank, Radhe K. Vaid

Publikováno v: Synthesis. 46:2463-2470

A high-yielding five-step synthesis of the title compound, methyl 7,9-dimethyl-5-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carboxylate, starting from 2,4-dimethylaniline was developed. This synthesis involved N-alkylation of 2,4-dimethylaniline w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cc99d123bce7a756e56d091e4564e0e9
https://doi.org/10.1055/s-0034-1378279

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Development of a Hydrogenative Reductive Amination for the Synthesis of Evacetrapib: Unexpected Benefits of Water

Autor: Michael O. Frederick, Michael E. LeTourneau, K. Derek Berglund, Adler W. Edward, Scott Alan Frank, Charles A. Alt, Jeffrey Thomas Vicenzi

Publikováno v: Organic Process Research & Development. 18:546-551

For the synthesis of cholesteryl ester transfer protein (CETP) inhibitor evacetrapib, a hydrogenative reductive amination was chosen to join the substituted cyclohexyl subunit to the benzazepine core. The addition of water, which suppressed undesired

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f1dda988fcce21a7d9cb305e2db1704e
https://doi.org/10.1021/op500025v

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Counterion effects in the preparation of aldehyde–bisulfite adducts

Autor: Jeffrey Thomas Vicenzi, Paul A. Stroud, Gregory A. Rener, Gregory A. Stephenson, Marie Kissane, Scott Alan Frank, Radhe K. Vaid, Sathish K. Boini, Charles A. Alt, Laura A. McKee, Christopher P. Ley

Publikováno v: Tetrahedron Letters. 54:6587-6591

The identification and development of an aldehyde–bisulfite adduct as an isolable starting material in the synthesis of the CETP inhibitor Evacetrapib are described. The physical properties of the sodium and potassium analogs are compared, and the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::db61e5c1cead81ae0ad227ab59249502
https://doi.org/10.1016/j.tetlet.2013.09.105

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Process Development and Pilot-Plant Synthesis of (2-Chlorophenyl)[2-(phenylsulfonyl)pyridin-3-yl]methanone

Autor: Charles A. Alt, Dilwyn J. Roberts, Alfio Borghese, Kobierski Michael Edward, Anita R. Maguire, Michael E. Kopach, Orla A. McNamara, Marie Kissane, Tony Y. Zhang, Humphrey A. Moynihan, William G. Trankle, Kurt T. Lorenz, D. Scott Coffey

Publikováno v: Organic Process Research & Development. 14:1229-1238

Routes to (2-chlorophenyl)[2-(phenylsulfonyl)pyridin-3-yl]methanone, 1, an intermediate in the manufacture of NK1-II inhibitor LY686017 are described which produce 1 in >75% yield and 95% purity. A highly selective telescoped ortho lithation/condensa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4ddf88f9c08a10717d79215072220659
https://doi.org/10.1021/op100157q

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Optimization of the Hardening Properties of Refractory Castables Using Nondestructive Techniques to Measure Early Age Properties

Autor: Christoph Wöhrmeyer, Charles Walter Alt, Christopher Parr, Michaël Lievin

Publikováno v: International Journal of Applied Ceramic Technology. 4:524-534

A significant part of downtime during the installation of refractory castables is spent waiting for hardening to occur so that molds and formwork can be stripped. In order to reduce this downtime, an optimization of the hardening properties is necess

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8762bbccff706a8580a1bfa87045a25a
https://doi.org/10.1111/j.1744-7402.2007.02171.x

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