Zobrazeno 1 - 10
of 1 084
pro vyhledávání: '"Charles A Dinarello"'
Publikováno v:
Neural Regeneration Research, Vol 19, Iss 10, Pp 2189-2201 (2024)
Metabolism is a fundamental process by which biochemicals are broken down to produce energy (catabolism) or used to build macromolecules (anabolism). Metabolism has received renewed attention as a mechanism that generates molecules that modulate mult
Externí odkaz:
https://doaj.org/article/3d4cac3cd72b4c4c9dff25d542cb7faf
Autor:
Niklas Lonnemann, Shirin Hosseini, Melanie Ohm, Robert Geffers, Karsten Hiller, Charles A Dinarello, Martin Korte
Publikováno v:
eLife, Vol 11 (2022)
The anti-inflammatory cytokine interleukin-37 (IL-37) belongs to the IL-1 family but is not expressed in mice. We used a human IL-37 (hIL-37tg) expressing mouse, which has been subjected to various models of local and systemic inflammation as well as
Externí odkaz:
https://doaj.org/article/73da99971b48472caa9fc968ea7b69a4
Autor:
Rodrigo Saar Gomes, Muriel Vilela Teodoro Silva, Jéssica Cristina dos Santos, Lucas Luiz de Lima Silva, Aline Carvalho Batista, Juliana Reis Machado, Mauro Martins Teixeira, Miriam Leandro Dorta, Milton Adriano Pelli de Oliveira, Charles A Dinarello, Leo A. B. Joosten, Fátima Ribeiro-Dias
Publikováno v:
Parasites & Vectors, Vol 10, Iss 1, Pp 1-7 (2017)
Abstract Background Interleukin 32 (IL-32) is a pro-inflammatory cytokine induced in patients with American tegumentary leishmaniasis (ATL) caused by Leishmania braziliensis. Here, we investigated whether IL-32 is also expressed in patient lesions ca
Externí odkaz:
https://doaj.org/article/1467cc628217461d97fe02cc884e87dd
Autor:
Nupur Aggarwal, Elena Korenbaum, Ravi Mahadeva, Stephan Immenschuh, Veronika Grau, Charles A Dinarello, Tobias Welte, Sabina Janciauskiene
Publikováno v:
Molecular Medicine, Vol 22, Iss 1, Pp 680-693 (2016)
Abstract Alphal-antitrypsin (A1AT, SERPINA1), a major circulating inhibitor of neutrophil elastase (NE) and protelnase-3 (PR3), has been proposed to reduce the processing and release of IL-1β. Since the antiinflammatory properties of A1AT are influe
Externí odkaz:
https://doaj.org/article/0cbbef4b78ad44488f7ebff8446bae95
Autor:
Erik J M Toonen, Andreea-Manuela Mirea, Cees J Tack, Rinke Stienstra, Dov B Ballak, Janna A van Diepen, Anneke Hijmans, Triantafyllos Chavakis, Wim H Dokter, Christine T N Pham, Mihai G Netea, Charles A Dinarello, Leo A B Joosten
Publikováno v:
Molecular Medicine, Vol 22, Iss 1, Pp 202-214 (2016)
Abstract Activation of inflammatory pathways is known to accompany development of obesity-induced nonalcoholic fatty liver disease (NAFLD), insulin resistance and type 2 diabetes. In addition to caspase-1, the neutrophil serine proteases proteinase 3
Externí odkaz:
https://doaj.org/article/9fd3b3e028b347669261286dd8c2a8d2
Autor:
Jéssica Cristina Dos Santos, Bas Heinhuis, Rodrigo Saar Gomes, Michelle S M A Damen, Fernando Real, Renato A Mortara, Samuel T Keating, Charles A Dinarello, Leo A B Joosten, Fátima Ribeiro-Dias
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 2, p e0005413 (2017)
BACKGROUND:Interleukin-32 (IL-32) is expressed in lesions of patients with American Tegumentary Leishmaniasis (ATL), but its precise role in the disease remains unknown. METHODOLOGY/PRINCIPAL FINDINGS:In the present study, silencing and overexpressio
Externí odkaz:
https://doaj.org/article/16254dd2fbcc4966b9d3480570e35e4a
Autor:
James C Needell, Charles A Dinarello, Diana Ir, Charles E Robertson, Sarah M Ryan, Miranda E Kroehl, Daniel N Frank, Danny Zipris
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0173968 (2017)
Type 1 diabetes (T1D) is an autoimmune proinflammatory disease with no effective intervention. A major obstacle in developing new immunotherapies for T1D is the lack of means for monitoring immune responsiveness to experimental therapies. The LEW1.WR
Externí odkaz:
https://doaj.org/article/f84931f6243747b199a58e9a109592d1
Autor:
Nuria Maicas, Johan van der Vlag, Janin Bublitz, Sandrine Florquin, Marinka Bakker-van Bebber, Charles A Dinarello, Vivienne Verweij, Roos Masereeuw, Leo A Joosten, Luuk B Hilbrands
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0168981 (2017)
Several lines of evidence have demonstrated the anti-inflammatory and cytoprotective effects of alpha-1-antitrypsin (AAT), the major serum serine protease inhibitor. The aim of the present study was to investigate the effects of human AAT (hAAT) mono
Externí odkaz:
https://doaj.org/article/5a0f3b22332645c1a74705e3e769d183
Autor:
Silvia Moretti, Silvia Bozza, Vasilis Oikonomou, Giorgia Renga, Andrea Casagrande, Rossana G Iannitti, Matteo Puccetti, Cecilia Garlanda, Soohyun Kim, Suzhao Li, Frank L van de Veerdonk, Charles A Dinarello, Luigina Romani
Publikováno v:
PLoS Pathogens, Vol 10, Iss 11, p e1004462 (2014)
Since IL-37 transgenic mice possesses broad anti-inflammatory properties, we assessed whether recombinant IL-37 affects inflammation in a murine model of invasive pulmonary aspergillosis. Recombinant human IL-37 was injected intraperitoneally into mi
Externí odkaz:
https://doaj.org/article/70c8b28e16f74b89bfdc619bd4278ed1
Autor:
Mark S Gresnigt, Silvia Bozza, Katharina L Becker, Leo A B Joosten, Shahla Abdollahi-Roodsaz, Wim B van der Berg, Charles A Dinarello, Mihai G Netea, Thierry Fontaine, Antonella De Luca, Silvia Moretti, Luigina Romani, Jean-Paul Latge, Frank L van de Veerdonk
Publikováno v:
PLoS Pathogens, Vol 10, Iss 3, p e1003936 (2014)
The galactosaminogalactan (GAG) is a cell wall component of Aspergillus fumigatus that has potent anti-inflammatory effects in mice. However, the mechanisms responsible for the anti-inflammatory property of GAG remain to be elucidated. In the present
Externí odkaz:
https://doaj.org/article/10d1a75fb68745c3a14d58e7dd727dc6