Zobrazeno 1 - 10
of 1 759
pro vyhledávání: '"Charles A Dinarello"'
Autor:
Martin Jaeger, Axel Dietschmann, Sophie Austermeier, Sude Dinçer, Pauline Porschitz, Larsen Vornholz, Ralph J.A. Maas, Evelien G.G. Sprenkeler, Jürgen Ruland, Stefan Wirtz, Tania Azam, Leo A.B. Joosten, Bernhard Hube, Mihai G. Netea, Charles A. Dinarello, Mark S. Gresnigt
Publikováno v:
Virulence, Vol 15, Iss 1 (2024)
ABSTRACTOur immune system possesses sophisticated mechanisms to cope with invading microorganisms, while pathogens evolve strategies to deal with threats imposed by host immunity. Human plasma protein α1-antitrypsin (AAT) exhibits pleiotropic immune
Externí odkaz:
https://doaj.org/article/69c249b8532c4a85b4278d546bfe2770
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Decades of evidence positioned IL-1β as a master regulatory cytokine in acute and chronic inflammatory diseases. Approved biologics aimed at inhibiting IL-1 signaling have shown efficacy but variable safety. More recently, targeting NLRP3 activation
Externí odkaz:
https://doaj.org/article/efa6c2d534e9490f99a32ee57d8cbe70
Autor:
Liqiong Jiang, Lars P. Lunding, William S. Webber, Karsten Beckmann, Tania Azam, Jesper Falkesgaard Højen, Jesus Amo-Aparicio, Alberto Dinarello, Tom T. Nguyen, Ulrich Pessara, Daniel Parera, David J. Orlicky, Stephan Fischer, Michael Wegmann, Charles A. Dinarello, Suzhao Li
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionInterleukin-18 (IL-18), a pro-inflammatory cytokine belonging to the IL-1 Family, is a key mediator ofautoinflammatory diseases associated with the development of macrophage activation syndrome (MAS).High levels of IL-18 correlate with MA
Externí odkaz:
https://doaj.org/article/043b9fc676264481860d024fe524374a
Publikováno v:
Neural Regeneration Research, Vol 19, Iss 10, Pp 2189-2201 (2024)
Metabolism is a fundamental process by which biochemicals are broken down to produce energy (catabolism) or used to build macromolecules (anabolism). Metabolism has received renewed attention as a mechanism that generates molecules that modulate mult
Externí odkaz:
https://doaj.org/article/3d4cac3cd72b4c4c9dff25d542cb7faf
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-14 (2023)
Abstract Background Parkinson’s disease (PD) is characterized by a progressive degeneration of dopaminergic neurons, which leads to irreversible loss of peripheral motor functions. Death of dopaminergic neurons induces an inflammatory response in m
Externí odkaz:
https://doaj.org/article/9e771736560b44e886618201a2fdbb1f
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
This Perspective highlights the work of Dr. Daniela Novick in the field of cytokine biology. Using affinity chromatography to characterize cytokine-binding proteins, she identified soluble forms of the receptors as well as binding proteins for severa
Externí odkaz:
https://doaj.org/article/11f6643b08224e2d8089c959066f1c26
Autor:
Dennis M. deGraaf, Lisa U. Teufel, Aline H. deNooijer, Adriaan J. vanGammeren, Antonius A. M. Ermens, Ildikó O. Gaál, Tania O. Crișan, Frank L. van deVeerdonk, Mihai G. Netea, Charles A. Dinarello, Leo A. B. Joosten, Rob J. W. Arts, the Radboudumc Center for Infectious Diseases COVID‐19 Study Group
Publikováno v:
Immunity, Inflammation and Disease, Vol 10, Iss 11, Pp n/a-n/a (2022)
Abstract Introduction A major contributor to coronavirus disease 2019 (COVID‐19) progression and severity is a dysregulated innate and adaptive immune response. Interleukin‐38 (IL−38) is an IL‐1 family member with broad anti‐inflammatory pr
Externí odkaz:
https://doaj.org/article/316ee342c38842a0b2005fa7521bb057
Autor:
Lisa U. Teufel, Dennis M. de Graaf, Mihai G. Netea, Charles A. Dinarello, Leo A. B. Joosten, Rob J. W. Arts
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Interleukin (IL)-38 is the latest discovered member of the interleukin-1 family, which has anti-inflammatory properties similar to IL-36Ra. Several studies compared circulating IL-38 concentrations in healthy and diseased populations to characterize
Externí odkaz:
https://doaj.org/article/86943f4fdc194ef38b8d75450095bfb1
Autor:
Niklas Lonnemann, Shirin Hosseini, Melanie Ohm, Robert Geffers, Karsten Hiller, Charles A Dinarello, Martin Korte
Publikováno v:
eLife, Vol 11 (2022)
The anti-inflammatory cytokine interleukin-37 (IL-37) belongs to the IL-1 family but is not expressed in mice. We used a human IL-37 (hIL-37tg) expressing mouse, which has been subjected to various models of local and systemic inflammation as well as
Externí odkaz:
https://doaj.org/article/73da99971b48472caa9fc968ea7b69a4
Impact of rare and common genetic variation in the interleukin-1 pathway on human cytokine responses
Autor:
Rosanne C. van Deuren, Peer Arts, Giulio Cavalli, Martin Jaeger, Marloes Steehouwer, Maartje van de Vorst, Christian Gilissen, Leo A. B. Joosten, Charles A. Dinarello, Musa M. Mhlanga, Vinod Kumar, Mihai G. Netea, Frank L. van de Veerdonk, Alexander Hoischen
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-17 (2021)
Abstract Background The interleukin (IL)-1 pathway is primarily associated with innate immunological defense and plays a major role in the induction and regulation of inflammation. Both common and rare genetic variation in this pathway underlies vari
Externí odkaz:
https://doaj.org/article/4f807526dbda4a1cb58bbb898e80286a