Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Charles A, Lesburg"'
Autor:
David A. Candito, Vladimir Simov, Anmol Gulati, Solomon Kattar, Ryan W. Chau, Blair T. Lapointe, Joey L. Methot, Duane E. DeMong, Thomas H. Graham, Ravi Kurukulasuriya, Mitchell H. Keylor, Ling Tong, Gregori J. Morriello, John J. Acton, Barbara Pio, Weiguo Liu, Jack D. Scott, Michael J. Ardolino, Theodore A. Martinot, Matthew L. Maddess, Xin Yan, Hakan Gunaydin, Rachel L. Palte, Spencer E. McMinn, Lisa Nogle, Hongshi Yu, Ellen C. Minnihan, Charles A. Lesburg, Ping Liu, Jing Su, Laxminarayan G. Hegde, Lily Y. Moy, Janice D. Woodhouse, Robert Faltus, Tina Xiong, Paul Ciaccio, Jennifer A. Piesvaux, Karin M. Otte, Matthew E. Kennedy, David Jonathan Bennett, Erin F. DiMauro, Matthew J. Fell, Santhosh Neelamkavil, Harold B. Wood, Peter H. Fuller, J. Michael Ellis
Publikováno v:
Journal of Medicinal Chemistry. 65:16801-16817
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::365ba0e1a6a6d085b4344b637344b726
https://doi.org/10.1021/acs.jmedchem.2c01605
https://doi.org/10.1021/acs.jmedchem.2c01605
Autor:
Anandan Palani, Matthew Lloyd Childers, Qinglin Pu, Matthew J. Mitcheltree, Symon Gathiaka, Christian Fischer, Lisa Nogle, Rachel L. Palte, Jared N. Cumming, J. Richard Miller, Spencer McMinn, Hai-Young Kim, Hongjun Zhang, Charles A. Lesburg, Adam Beard, Donovon A. Adpressa, Josep Saurí, Derun Li, Theodore A. Martinot, Thomas W. Lyons, David L. Sloman, Jialiang Wang, Peter Spacciapoli, Min Lu, Abdelghani Achab
Publikováno v:
ACS Med Chem Lett
[Image: see text] Comprehensive synthetic strategies afforded a diverse set of structurally unique bicyclic proline-containing arginase inhibitors with a high degree of three-dimensionality. The analogs that favored the Cγ-exo conformation of the pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::355a3f9279f9db6a241567d164d50d64
https://doi.org/10.1021/acsmedchemlett.1c00258
https://doi.org/10.1021/acsmedchemlett.1c00258
Autor:
Joey L. Methot, David A Candito, Sheila Ranganath, Zangwei Xu, Xavier Fradera, Abdelghani Achab, Erin F. DiMauro, Haiyan Xu, Samuel M. Levi, Brandon A. Vara, Brian M. Lacey, Mark Bittinger, Jennifer Piesvaux, Dustin M Smith, Alexander Pasternak, Jongwon Lim, David Jonathan Bennett, J. Richard Miller, Charles A. Lesburg, Shuhei Kawamura
Publikováno v:
ACS Med Chem Lett
[Image: see text] Hematopoietic progenitor kinase 1 (HPK1), a serine/threonine kinase, is a negative immune regulator of T cell receptor (TCR) and B cell signaling that is primarily expressed in hematopoietic cells. Accordingly, it has been reported
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3974d15fa6854f44fa7ca9ad4baa4e1b
https://doi.org/10.1021/acsmedchemlett.1c00096
https://doi.org/10.1021/acsmedchemlett.1c00096
Autor:
Alexander C. Brueckner, Ann E. Cleves, Edward C. Sherer, Qiaolin Deng, Mikhail Reibarkh, Ajay N. Jain, Charles A. Lesburg, Juan C. Alvarez
Publikováno v:
Journal of Medicinal Chemistry. 64:3282-3298
Macrocyclic peptides are an important modality in drug discovery, but molecular design is limited due to the complexity of their conformational landscape. To better understand conformational propensities, global strain energies were estimated for 156
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42213055d2f2991f2d1c48c5b3fdf836
https://doi.org/10.1021/acs.jmedchem.0c02159
https://doi.org/10.1021/acs.jmedchem.0c02159
Autor:
Charles A. Lesburg, Alexander C. Brueckner, Qiaolin Deng, Ann E. Cleves, Edward C. Sherer, Mikhail Reibarkh, Ajay N. Jain
Publikováno v:
Journal of Medicinal Chemistry. 63:10509-10528
We report a new method for X-ray density ligand fitting and refinement that is suitable for a wide variety of small-molecule ligands, including macrocycles. The approach (called "xGen") augments a force field energy calculation with an electron densi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de61ef0c116f6c0ccb929b0da9c853df
https://doi.org/10.1021/acs.jmedchem.0c01373
https://doi.org/10.1021/acs.jmedchem.0c01373
Autor:
Nicolas Solban, Alexander Pasternak, Qinglin Pu, Amy C. Doty, David Jonathan Bennett, Charles A. Lesburg, Wensheng Yu, Prasanthi Geda, Nunzio Sciammetta, J. Richard Miller, Hua Zhou, Xuelei Song, Yongxin Han, Lars Neumann, David L. Sloman, Mangeng Cheng, Heidi Ferguson, Karin M. Otte, Liangqin Guo, Hongjun Zhang, Alfred Lammens, Xavier Fradera, Meredeth A. McGowan
Publikováno v:
ACS Med Chem Lett
[Image: see text] Indoleamine-2,3-dioxygenase 1 (IDO1) inhibition and its combination with immune checkpoint inhibitors like pembrolizumab have drawn considerable attention from both academia and the pharmaceutical industry. Here, we describe the dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bc457a333eeebf89280777405619540
https://doi.org/10.1021/acsmedchemlett.0c00195
https://doi.org/10.1021/acsmedchemlett.0c00195
Autor:
Andrew M. Haidle, Antonella Converso, Harold B. Wood, Daniel J. Klein, John M. Sanders, Charles A. Lesburg, Ying-Duo Gao, Yi Zang, Matthew Tudor, Xin Cindy Yan
Publikováno v:
Journal of Chemical Information and Modeling. 60:4144-4152
Two orthogonal approaches for hit identification in drug discovery are large-scale in vitro and in silico screening. In recent years, due to the emergence of new targets and a rapid increase in the...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d63d4ad60d3f5dfa0073eda91ef61f12
https://doi.org/10.1021/acs.jcim.0c00113
https://doi.org/10.1021/acs.jcim.0c00113
Autor:
Matthew J. Mitcheltree, Theodore A. Martinot, Thomas W. Lyons, Spencer McMinn, Peter W. Fan, Hyelim Cho, Christian Fischer, Kalyan Chakravarthy, David L. Sloman, Padmanabhan Eangoor, Jared N. Cumming, Charles A. Lesburg, Mangeng Cheng, Adam Beard, Derun Li, Hongjun Zhang, Jennifer O'Neil, Abdelghani Achab, Rachel L. Palte, Anandan Palani, J. Richard Miller, Josep Saurí, Symon Gathiaka, Hai-Young Kim
Publikováno v:
ACS Med Chem Lett
[Image: see text] The action of arginase, a metalloenzyme responsible for the hydrolysis of arginine to urea and ornithine, is hypothesized to suppress immune-cell activity within the tumor microenvironment, and thus its inhibition may constitute a m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bf7e118f47c67e176705e85f740b968
https://doi.org/10.1021/acsmedchemlett.0c00058
https://doi.org/10.1021/acsmedchemlett.0c00058
Autor:
Wonsuk Chang, Michael D. Altman, Charles A. Lesburg, Samanthi A. Perera, Jennifer A. Piesvaux, Gottfried K. Schroeder, Daniel F. Wyss, Saso Cemerski, Yiping Chen, Edward DiNunzio, Andrew M. Haidle, Thu Ho, Ilona Kariv, Ian Knemeyer, Johnny E. Kopinja, Brian M. Lacey, Jason Laskey, Jongwon Lim, Brian J. Long, Yanhong Ma, Matthew L. Maddess, Bo-Sheng Pan, Jeremy P. Presland, Edward Spooner, Dietrich Steinhuebel, Quang Truong, Zhibo Zhang, Jianmin Fu, George H. Addona, Alan B. Northrup, Emma Parmee, James R. Tata, David Jonathan Bennett, Jared N. Cumming, Tony Siu, B. Wesley Trotter
Publikováno v:
Journal of medicinal chemistry. 65(7)
Stereochemically and structurally complex cyclic dinucleotide-based stimulator of interferon genes (STING) agonists were designed and synthesized to access a previously unexplored chemical space. The assessment of biochemical affinity and cellular po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06368ab6dd14d5ea28c031fb685e4dae
https://pubmed.ncbi.nlm.nih.gov/35332774
https://pubmed.ncbi.nlm.nih.gov/35332774
Autor:
Derun Li, David L. Sloman, Abdelghani Achab, Hua Zhou, Meredeth A. McGowan, Catherine White, Craig Gibeau, Hongjun Zhang, Qinglin Pu, Indu Bharathan, Brett Hopkins, Kun Liu, Heidi Ferguson, Xavier Fradera, Charles A. Lesburg, Theodore A. Martinot, Ji Qi, Zhiguo J. Song, Jingjun Yin, Huangguang Zhang, Licheng Song, Baoqiang Wan, Suzanne DAddio, Nicolas Solban, J. Richard Miller, Beata Zamlynny, Alan Bass, Elizabeth Freeland, Bridget Ykoruk, Catherine Hilliard, Jude Ferraro, Jin Zhai, Ian Knemeyer, Karin M. Otte, Stella Vincent, Nunzio Sciammetta, Alexander Pasternak, David Jonathan Bennett, Yongxin Han
Publikováno v:
Journal of medicinal chemistry. 65(8)
3,3-Disubstituted oxetanes have been utilized as bioisosteres for gem-dimethyl and cyclobutane functionalities. We report the discovery of a novel class of oxetane indole-amine 2,3-dioxygenase (IDO1) inhibitors suitable for Q3W (once every 3 weeks) o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f65de888aa90fb7088ca022d5b5ddf12
https://pubmed.ncbi.nlm.nih.gov/35239336
https://pubmed.ncbi.nlm.nih.gov/35239336