Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Charles A, Galea"'
Autor:
Garima Jaipuria, Divya Shet, Shahid Malik, Monalisa Swain, Hanudatta S. Atreya, Charles A. Galea, Mark G. Slomiany, Steven A. Rosenzweig, Briony E. Forbes, Raymond Norton, Somnath Mondal
Publikováno v:
Proteins
Functional regulation via conformational dynamics is well known in structured proteins, but less well characterized in intrinsically disordered proteins and their complexes. Using NMR spectroscopy we have identified a dynamic regulatory mechanism in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bce3f977d1fd19019872055de6343e0
https://europepmc.org/articles/PMC9357107/
https://europepmc.org/articles/PMC9357107/
Autor:
Geneieve Tai, Susan Perlman, Martin B. Delatycki, Michael H Parkinson, Alexandra Durr, Marguerite V. Evans-Galea, Françoise Pousset, Paola Giunti, Lyle C. Gurrin, Robyn Labrum, Sarah Gelbard, Charles A. Galea, Eppie M. Yiu, David A. Lynch, Aamira Huq, Louise A. Corben, Paul J. Lockhart
Publikováno v:
Annals of Neurology. 79:485-495
Objective Friedreich ataxia (FRDA) is an inherited neurodegenerative disease characterized by ataxia and cardiomyopathy. Homozygous GAA trinucleotide repeat expansions in the first intron of FXN occur in 96% of affected individuals and reduce frataxi
Autor:
Mei-Ling Han, Yan Zhu, Tony Velkov, Jian L, Charles A. Galea, Kade D. Roberts, Philip E. Thompson, Jiping Wang
Publikováno v:
Journal of natural products. 80(5)
The increasing prevalence of polymyxin-resistant bacteria has stimulated the search for improved polymyxin lipopeptides. Here we describe the sequence and product profile for polymyxin D nonribosomal peptide synthetase from Paenibacillus polymyxa ATC
Autor:
Charles A, Galea
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1579
Membrane tethered matrix metalloproteases are bound to the plasma membrane by a glycosylphosphatidylinositol-anchor or a transmembrane domain. To date, most studies of membrane-bound matrix metalloprotease have focused on the globular catalytic and p
Publikováno v:
Biochemistry. 56(4)
Polymyxins remain one of the few antibiotics available for treating antibiotic resistant bacteria. Here we describe polymyxin B thioesterase which performs the final step in polymyxin B biosynthesis. Isolated thioesterase catalyzed cyclization of an
Autor:
Amélie Piton, Melanie Bahlo, Paul J. Lockhart, Vesna Lukic, Caroline Nava, David J. Amor, Pierre Bitoun, Vicki Anderson, Fabien Lesne, Greta Gillies, Amanda G. Wood, Justine Guegan, Gail Robinson, Catherine Garel, Alexis Brice, Sarah E.M. Stephenson, Guy A. Rouleau, Aurélie Méneret, Delphine Héron, Kate Pope, Solveig Heide, Cyril Mignot, Emmanuel Roze, Angélique Quartier, Jean-Louis Mandel, Annalisa Paolino, Quentin Welniarz, Sylvie Odent, Florence Riant, George McGillivray, Linda J. Richards, Ilan Gobius, Elliott H. Sherr, Tania Attié-Bitach, Charles A. Galea, Timothy J. Edwards, Myriam Srour, Megan Spencer-Smith, Oriane Trouillard, Laura Morcom, Boris Keren, Christel Depienne, Marie Laure Moutard, Anne Faudet, Richard J. Leventer, Alissandra McIlroy, Agnès Rastetter, Thierry Billette de Villemeur, Simone Mandelstam, Jens Bunt, Martin B. Delatycki, Rick M. Tankard, Ashley P L Marsh
Publikováno v:
Nature Genetics
Nature Genetics, Nature Publishing Group, 2017, 49 (4), pp.511-514. ⟨10.1038/ng.3794⟩
Nature Genetics, Nature Publishing Group, 2017, 49 (4), pp.511-514. 〈10.1038/ng.3794〉
Nature Genetics, 2017, 49 (4), pp.511-514. ⟨10.1038/ng.3794⟩
Nature Genetics, Nature Publishing Group, 2017, 49 (4), pp.511-514. ⟨10.1038/ng.3794⟩
Nature Genetics, Nature Publishing Group, 2017, 49 (4), pp.511-514. 〈10.1038/ng.3794〉
Nature Genetics, 2017, 49 (4), pp.511-514. ⟨10.1038/ng.3794⟩
International audience; Brain malformations involving the corpus callosum are common in children with developmental disabilities. We identified DCC mutations in four families and five sporadic individuals with isolated agenesis of the corpus callosum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8ed48cf72d3e7ff3e948cd8c5c51c1d
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01502133/file/Mutations_in_DCC_cause_isolated_agenesis.pdf
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01502133/file/Mutations_in_DCC_cause_isolated_agenesis.pdf
Autor:
Charles A. Galea
Publikováno v:
Methods in Molecular Biology ISBN: 9781493968619
Membrane tethered matrix metalloproteases are bound to the plasma membrane by a glycosylphosphatidylinositol-anchor or a transmembrane domain. To date, most studies of membrane-bound matrix metalloprotease have focused on the globular catalytic and p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ab467bb0e1d53e14063a81a12960d81
https://doi.org/10.1007/978-1-4939-6863-3_2
https://doi.org/10.1007/978-1-4939-6863-3_2
Autor:
Gail Robinson, Saumya Shekhar Jamuar, Elizabeth C. Engle, Helen M. Cooper, Guy A. Rouleau, Ashley P L Marsh, Christel Depienne, Thierry Billette de Villemeur, Linda J. Richards, Elliott H. Sherr, Richard J. Leventer, Delphine Héron, Agnès Rastetter, Marie-Laure Moutard, Charles A. Galea, Oriane Trouillard, Paul J. Lockhart, Timothy W. Yu, Megan Spencer-Smith, Emmanuel Roze, Timothy J. Edwards, Aurélie Méneret, Caroline Nava, Christopher A. Walsh
Publikováno v:
Human Mutation
Human Mutation, 2017, 39 (1), pp.23-39. ⟨10.1002/humu.23361⟩
Human Mutation, 2017, 39 (1), pp.23-39. ⟨10.1002/humu.23361⟩
The deleted in colorectal cancer (DCC) gene encodes the netrin-1 receptor DCC, a transmembrane protein required for the guidance of commissural axons. Germline DCC mutations disrupt the development of predominantly commissural tracts in the central n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e35ca879a6fee9e2691af4f066f68561
https://hal.science/hal-03663180
https://hal.science/hal-03663180
Autor:
Keith K. Khoo, Mingyu Ye, Matthew A. Perugini, Chengwu Chi, Xiao-Xia Shao, Mi Zhou, Charles A. Galea, Shaoqiong Xu, Raymond S. Norton, Chunguang Wang, Nonlawat Boonyalai
Publikováno v:
Journal of Biological Chemistry. 287:14973-14983
Cone snail venoms are a rich source of peptides, many of which are potent and selective modulators of ion channels and receptors. Here we report the isolation and characterization of two novel conotoxins from the venom of Conus imperialis. These two
Autor:
Charles A. Galea, Raymond S. Norton, Terrence D. Mulhern, John C. Wallace, Briony E. Forbes, Glenn F. King, Mehdi Mobli, Kerrie A. McNeil
Publikováno v:
Biochimie. 94:608-616
The insulin-like growth factor binding proteins are a family of six proteins (IGFBP-1 to -6) that bind insulin-like growth factors-I and -II (IGF-I/II) with high affinity. In addition to regulating IGF actions, IGFBPs have IGF-independent functions.