Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Charles W. Hutchins"'
Autor:
Qi Hao, Manoj K. Rathinaswamy, Kelly L. Klinge, Matthew Bratkowski, Amirhossein Mafi, Christina K. Baumgartner, Keith M. Hamel, Gesine K. Veits, Rinku Jain, Claudio Catalano, Mark Fitzgerald, Alexander W. Hird, Eunice Park, Harit U. Vora, James A. Henderson, Kenton Longenecker, Charles W. Hutchins, Wei Qiu, Giovanna Scapin, Qi Sun, Vincent S. Stoll, Chaohong Sun, Ping Li, Dan Eaton, David Stokoe, Stewart L. Fisher, Christopher G. Nasveschuk, Marcia Paddock, Michael E. Kort
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-16 (2024)
Abstract PTPN2 (protein tyrosine phosphatase non-receptor type 2, or TC-PTP) and PTPN1 are attractive immuno-oncology targets, with the deletion of Ptpn1 and Ptpn2 improving response to immunotherapy in disease models. Targeted protein degradation ha
Externí odkaz:
https://doaj.org/article/1f2680b79836478cba894b08e1a585a6
Autor:
Wei Qiu, Qi Sun, Yi Yang, Chirag Patel, Meng Sun, Yue Liu, Kyle Halliwill, Sarah Kim, Rebecca Mathew, Jennifer M Frost, Jennifer A Roth, Domenick Kennedy, Robert T Manguso, Kathleen B Yates, Hakimeh Ebrahimi-Nik, Christina K Baumgartner, Arvin Iracheta-Vellve, Keith M Hamel, Kira Olander, Thomas GR Davis, Kathleen A McGuire, Geoff T Halvorsen, Omar I Avila, Ashwin V Kammula, Audrey J Muscato, Prasanthi Geda, Kelly Klinge, Zhaoming Xiong, Ryan Duggan, Liang Mu, Mitchell D Yeary, James C Patti, Tyler M Balon, Carey Backus, Angeline Chen, Kenton Longenecker, Joseph Klahn, Cara Hrusch, Navasona Krishnan, Charles W Hutchins, Jacqueline Aguado, Marinka Bulic, Payal Tiwari, Kayla J Colvin, Cun Lan Chuong, Ian C Kohnle, Matthew G Rees, Andrew Boghossian, Melissa Ronan, Meng-Ju Wu, Debattama R Sen, Gabriel K Griffin, Nabeel El-Bardeesy, Patricia Trusk, Joshua H Decker, Stacey Fossey, Marcia N Paddock, Elliot P Farney, Clay Beauregard, Philip R Kym
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 2 (2023)
Externí odkaz:
https://doaj.org/article/11356ff1bf1f4b63ab1324cafa253315
Autor:
John T. Randolph, Matthew J. O’Connor, Fei Han, Charles W. Hutchins, Y. Amy Siu, Min Cho, Yunan Zheng, Jonathan A. Hickson, Jana L. Markley, Vlasios Manaves, Mikkel Algire, Kenton A. Baker, Alex M. Chapman, Sujatha M. Gopalakrishnan, Sanjay C. Panchal, Kelly Foster-Duke, DeAnne F. Stolarik, Anita Kempf-Grote, Darby Dammeier, Stacey Fossey, Qi Sun, Chaohong Sun, Yu Shen, Michael J. Dart, Warren M. Kati, Albert Lai, Ari J. Firestone, Michael E. Kort
Publikováno v:
Journal of Medicinal Chemistry. 66:3852-3865
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::941bc4bfb75cae4284f6cb7de0cad715
https://doi.org/10.1021/acs.jmedchem.2c01415
https://doi.org/10.1021/acs.jmedchem.2c01415
Autor:
Andrea G. Shergalis, Violeta L. Marin, David Y. Rhee, Sameera Senaweera, Rebecca L. McCloud, Judith A. Ronau, Charles W. Hutchins, Shaun McLoughlin, Kevin R. Woller, Scott E. Warder, Anil Vasudevan, Justin M. Reitsma
Publikováno v:
ACS Chemical Biology. 18:331-339
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21c19f36bf74a5e7cb655d9ba46e9868
https://doi.org/10.1021/acschembio.2c00747
https://doi.org/10.1021/acschembio.2c00747
Autor:
David A. Degoey, Alessandra Mattei, Rodger F. Henry, Gabriela Schneider-Rauber, Moiz Diwan, Ahmad Y. Sheikh, Kenneth M. Engstrom, Erin Jordan, Nathan S. Abraham, Richard S. Hong, Vivian Juarez, Rajni Miglani Bhardwaj, Charles W. Hutchins, Yi Gao
Publikováno v:
Journal of the American Chemical Society. 143:17479-17491
Direct-acting antiviral regimens have transformed therapeutic management of hepatitis C across all prevalent genotypes. Most of the chemical matter in these regimens comprises molecules well outside the traditional drug development chemical space and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bc960f220e749f4646ae1b6bb63b569
https://doi.org/10.1021/jacs.1c06837
https://doi.org/10.1021/jacs.1c06837
Publikováno v:
F1000Research, Vol 5 (2016)
This review covers recent advances in the implementation of enabling chemistry technologies into the drug discovery process. Areas covered include parallel synthesis chemistry, high-throughput experimentation, automated synthesis and purification met
Externí odkaz:
https://doaj.org/article/bb1446431bde426eaa45879386fdbf34
Autor:
Keith F. McDaniel, Andrew Bogdan, Lisa A. Hasvold, Ana L. Aguirre, Denise Wilcox, Xiaoyu Lin, Le Wang, Mai H. Bui, Leiming Li, Warren M. Kati, Terrance J. Magoc, James H. Holms, Dachun Liu, Steven D. Fidanze, Justin D. Dietrich, Charles W. Hutchins, Ganesh Rajaraman, Yu Shen, George S. Sheppard, Rongqi Wang, Daniel H. Albert, Chang H. Park, Jasmina Marjanovic, Robert A. Mantei, Xiaoli Huang, Peter Kovar, Yujia Dai, John K. Pratt
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:1804-1810
Novel conformationally constrained BET bromodomain inhibitors have been developed. These inhibitors were optimized in two similar, yet distinct chemical series, the 6-methyl-1H-pyrrolo[2,3-c]pyridin-7(6H)-ones (A) and the 1-methyl-1H-pyrrolo[2,3-c]py
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec20af598ffa68abcb2f81c612b36b03
https://doi.org/10.1016/j.bmcl.2018.04.020
https://doi.org/10.1016/j.bmcl.2018.04.020
Autor:
Ganesh Rajaraman, Leiming Li, Daniel H. Albert, Ruth L. Martin, Terrance J. Magoc, Todd N. Soltwedel, Denise Wilcox, Xiaoli Huang, Chang H. Park, Steven W. Elmore, George S. Sheppard, Charles W. Hutchins, Dachun Liu, Chaohong C. Sun, Guowei Fang, Le Wang, Wenqing Gao, Robert A. Mantei, Rongqi Wang, Emily J. Faivre, Steven D. Fidanze, John K. Pratt, Xiaoyu Lin, Mai H. Bui, Shekman Wong, Scott E. Warder, Jianwei J. Shen, Rohinton P. Edalji, Lisa A. Hasvold, Warren M. Kati, Keith F. McDaniel, Yu Shen
Publikováno v:
Journal of Medicinal Chemistry. 60:8369-8384
The development of bromodomain and extraterminal domain (BET) bromodomain inhibitors and their examination in clinical studies, particularly in oncology settings, has garnered substantial recent interest. An effort to generate novel BET bromodomain i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e212dfdec3c29433c5f0baac7f9a9a8
https://doi.org/10.1021/acs.jmedchem.7b00746
https://doi.org/10.1021/acs.jmedchem.7b00746
Autor:
Wilfried Hornberger, Achim Moeller, Yanbin Lao, Kennan C. Marsh, Karla Drescher, Wicke Karsten, Andreas Kling, Ana Lucia Relo, Volker Nimmrich, Charles W. Hutchins, Katja Jantos, Helmut Mack
Publikováno v:
Journal of Medicinal Chemistry. 60:7123-7138
Calpain overactivation has been implicated in a variety of pathological disorders including ischemia/reperfusion injury, cataract formation, and neurodegenerative diseases such as Alzheimer's disease (AD). Herein we describe our efforts leading to th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c22512573f194ae025815e7aa3a15657
https://doi.org/10.1021/acs.jmedchem.7b00731
https://doi.org/10.1021/acs.jmedchem.7b00731
Autor:
Grier A. Wallace, Elzbieta Radziejewska, Susan C. Marchie, Jürgen Dinges, Kara L. Queeney, Charles W. Hutchins, David Banach, Christopher M. Harris, Eric Dominguez, Russell A. Judge, Maria A. Argiriadi, Jennifer DiMauro
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:2293-2296
S1P Lyase (SPL) has been described as a drug target in the treatment of autoimmune diseases. It plays an important role in maintaining intracellular levels of S1P thereby affecting T cell egress from lymphoid tissues. Several groups have already publ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd6853bcc358b9233f783ad0a44949c7
https://doi.org/10.1016/j.bmcl.2016.02.084
https://doi.org/10.1016/j.bmcl.2016.02.084