Splenic clearance of rigid erythrocytes as an inherited mechanism for splenomegaly and natural resistance to malaria

Autor: Benoît Henry, Geoffroy Volle, Hilaire Akpovi, Laure Gineau, Camille Roussel, Papa Alioune Ndour, Félicien Tossou, Felipe Suarez, Friso Palstra, Aurélie Fricot, Charlotte Chambrion, Julien Solinc, Julie Nguyen, Mathilde Garé, Florentin Aussenac, Charles-Henry Cottart, Christine Keyser, Rafiou Adamou, Magali Tichit, David Hardy, Nadine Fievet, Jérôme Clain, André Garcia, David Courtin, Olivier Hermine, Audrey Sabbagh, Pierre Buffet

Publikováno v: EBioMedicine, Vol 82, Iss , Pp 104167- (2022)

Summary: Background: In malaria-endemic areas, subjects from specific groups like Fulani have a peculiar protection against malaria, with high levels of IgM but also frequent anaemia and splenomegaly. The mechanisms underlying this phenotype remain e

Externí odkaz: https://doaj.org/article/44ce45a575c74486830d8723e954cac6

Resveratrol metabolism in a non-human primate, the grey mouse lemur (Microcebus murinus), using ultra-high-performance liquid chromatography-quadrupole time of flight.

Autor: Marie-Claude Menet, Julia Marchal, Alexandre Dal-Pan, Méryam Taghi, Valérie Nivet-Antoine, Delphine Dargère, Olivier Laprévote, Jean-Louis Beaudeux, Fabienne Aujard, Jacques Epelbaum, Charles-Henry Cottart

Publikováno v: PLoS ONE, Vol 9, Iss 3, p e91932 (2014)

The grey mouse lemur (Microcebus murinus) is a non-human primate used to study the ageing process. Resveratrol is a polyphenol that may increase lifespan by delaying age-associated pathologies. However, no information about resveratrol absorption and

Externí odkaz: https://doaj.org/article/3681fdecb9344a0e82ba75d909220b0e

Systemic corticosteroids for the treatment of acute episodes of rhabdomyolysis in lipin‐1‐deficient patients

Autor: Caroline Tuchmann‐Durand, Célina Roda, Perrine Renard, Guillaume Mortamet, Claire‐Marine Bérat, Lucile Altenburger, Marie Hug de Larauz, Eloise Thevenet, Charles‐Henry Cottart, Florence Moulin, Juliette Bouchereau, Anais Brassier, Jean‐Baptiste Arnoux, Manuel Schiff, Nathalie Bednarek, Delphine Lamireau, Alexa Garros, Karine Mention, Aline Cano, Lionel Finger, Michele Pelosi, Cécile Sergent Brochet, Laure Caccavelli, Jean‐Herlé Raphalen, Sylvain Renolleau, Mehdi Oualha, Pascale de Lonlay

Publikováno v: Journal of Inherited Metabolic Disease.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7125875ae332dfeb32f0905a37892222
https://doi.org/10.1002/jimd.12592

Characterization of two rat models of cystic fibrosis—KO and F508del CFTR—Generated by Crispr‐Cas9

Autor: Marc Chanson, Louise Galmiche, Elise Dreano, Laurent Tesson, Juliette Lynn Simonin, Isabelle Sermet-Gaudelus, Marc Bacchetta, Claire Usal, Jérémy Sadoine, Lotfi Slimani, A. Hatton, Charles-Henry Cottart, Danielle Tondelier, Lucile Vignaud, Ignacio Anegon, Jean-Paul Concordet

Publikováno v: Animal Model Exp Med / Animal models and experimental medicine.
Animal Model Exp Med / Animal models and experimental medicine., [Hoboken, New Jersey] : John Wiley & Sons, Inc., [2018]-, 2019, 2 (4), pp.297-311. ⟨10.1002/ame2.12091⟩
Animal Models and Experimental Medicine, Vol 2, Iss 4, Pp 297-311 (2019)
Animal Model Exp Med / Animal models and experimental medicine., 2019, 2 (4), pp.297-311. ⟨10.1002/ame2.12091⟩
Animal Models and Experimental Medicine, Vol. 2, No 4 (2019) pp. 297-311
Animal Models and Experimental Medicine

International audience; Background:Genetically engineered animals are essential for gaining a proper understanding of the disease mechanisms of cystic fibrosis (CF). The rat is a relevant laboratory model for CF because of its zootechnical capacity,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ec644ae68a5940bab844a63063d995e
https://www.hal.inserm.fr/inserm-02458316/file/Dreano_et_al-2019-Animal_Models_and_Experimental_Medicine.pdf

Airway surface liquid acidification initiates host defense abnormalities in Cystic Fibrosis

Autor: Lhousseine Touqui, Sabrina Noël, Bérengère Villeret, Gilles Crambert, Isabelle Sermet-Gaudelus, Nesrine Baatallah, Aleksander Edelman, Elise Dreano, Emmanuelle Bille, Anita Golec, Aurélie Hatton, Juliette Simonin, Valérie Urbach, Xavier Nassif, Luis J. V. Galietta, Charles-Henry Cottart, Gabrielle Planelles, Alexandre Hinzpeter, Iwona Pranke, Jean-Michel Sallenave, Jean-Patrick Vrel, Aurélie Edwards

Publikováno v: Scientific Reports
Scientific Reports, 2019, 9, pp.6516. ⟨10.1038/s41598-019-42751-4⟩
Scientific Reports, Nature Publishing Group, 2019, 9 (1), ⟨10.1038/s41598-019-42751-4⟩
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports, Nature Publishing Group, 2019, 9, pp.6516. ⟨10.1038/s41598-019-42751-4⟩

Cystic fibrosis (CF) is caused by defective Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein. Morbidity is mainly due to early airway infection. We hypothesized that S. aureus clearance during the first hours of infection was impair

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::448d0956221b51b11700e76f52392f9a
https://doi.org/10.1038/s41598-019-42751-4