Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Charles, Redwood"'
Autor:
Zeyu Yang, Alice M. Sheehan, Andrew E. Messer, Sharmane Tsui, Alexander Sparrow, Charles Redwood, Vladimir Kren, Ian R. Gould, Steven B. Marston
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
IntroductionAdrenergic activation of protein kinase A (PKA) in cardiac muscle targets the sarcolemma, sarcoplasmic reticulum, and contractile apparatus to increase contractile force and heart rate. In the thin filaments of the contractile apparatus,
Externí odkaz:
https://doaj.org/article/1cf510ec54604089a056970300248a0b
Autor:
Vasco Sequeira, Lili Wang, Paul J.M. Wijnker, Kyungsoo Kim, Jose R. Pinto, Cris dos Remedios, Charles Redwood, Bjorn C. Knollmann, Jolanda van der Velden
Publikováno v:
Journal of Molecular and Cellular Cardiology Plus, Vol 1, Iss , Pp 100007- (2022)
Background: Hypertrophic cardiomyopathy (HCM) is an autosomal dominant genetic disorder with patients typically showing heterozygous inheritance of a pathogenic variant in a gene encoding a contractile protein. Here, we study the contractile effects
Externí odkaz:
https://doaj.org/article/b360c922580f4c239424f598c7d8a20a
Disease modeling of a mutation in α‐actinin 2 guides clinical therapy in hypertrophic cardiomyopathy
Autor:
Maksymilian Prondzynski, Marc D Lemoine, Antonia TL Zech, András Horváth, Vittoria Di Mauro, Jussi T Koivumäki, Nico Kresin, Josefine Busch, Tobias Krause, Elisabeth Krämer, Saskia Schlossarek, Michael Spohn, Felix W Friedrich, Julia Münch, Sandra D Laufer, Charles Redwood, Alexander E Volk, Arne Hansen, Giulia Mearini, Daniele Catalucci, Christian Meyer, Torsten Christ, Monica Patten, Thomas Eschenhagen, Lucie Carrier
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 8, Pp n/a-n/a (2022)
Externí odkaz:
https://doaj.org/article/20088ae3e8874325a43b88d720c8d7fd
Disease modeling of a mutation in α‐actinin 2 guides clinical therapy in hypertrophic cardiomyopathy
Autor:
Maksymilian Prondzynski, Marc D Lemoine, Antonia TL Zech, András Horváth, Vittoria Di Mauro, Jussi T Koivumäki, Nico Kresin, Josefine Busch, Tobias Krause, Elisabeth Krämer, Saskia Schlossarek, Michael Spohn, Felix W Friedrich, Julia Münch, Sandra D Laufer, Charles Redwood, Alexander E Volk, Arne Hansen, Giulia Mearini, Daniele Catalucci, Christian Meyer, Torsten Christ, Monica Patten, Thomas Eschenhagen, Lucie Carrier
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 12, Pp 1-18 (2019)
Abstract Hypertrophic cardiomyopathy (HCM) is a cardiac genetic disease accompanied by structural and contractile alterations. We identified a rare c.740C>T (p.T247M) mutation in ACTN2, encoding α‐actinin 2 in a HCM patient, who presented with lef
Externí odkaz:
https://doaj.org/article/3dc134090e7a4e27beee5c5b257be092
Autor:
Maksymilian Prondzynski, Elisabeth Krämer, Sandra D. Laufer, Aya Shibamiya, Ole Pless, Frederik Flenner, Oliver J. Müller, Julia Münch, Charles Redwood, Arne Hansen, Monica Patten, Thomas Eschenhagen, Giulia Mearini, Lucie Carrier
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 7, Iss C, Pp 475-486 (2017)
Gene therapy is a promising option for severe forms of genetic diseases. We previously provided evidence for the feasibility of trans-splicing, exon skipping, and gene replacement in a mouse model of hypertrophic cardiomyopathy (HCM) carrying a mutat
Externí odkaz:
https://doaj.org/article/285f249a121446408d9780a45f0af2f9
Autor:
Nico Kresin, Sabrina Stücker, Elisabeth Krämer, Frederik Flenner, Giulia Mearini, Julia Münch, Monica Patten, Charles Redwood, Lucie Carrier, Felix W. Friedrich
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Background: Many forms of hypertrophic cardiomyopathy (HCM) show an increased myofilament Ca2+ sensitivity. This observation has been mainly made in HCM mouse models, myofilament systems, and cardiomyocytes. Studies of multicellular tissues from pati
Externí odkaz:
https://doaj.org/article/9afd9321f0244aeeaedb90d00b1f6ea0
Publikováno v:
Biology, Vol 9, Iss 11, p 402 (2020)
Recent advances have made pluripotent stem cell (PSC)-derived cardiomyocytes an attractive option to model both normal and diseased cardiac function at the single-cell level. However, in vitro differentiation yields heterogeneous populations of cardi
Externí odkaz:
https://doaj.org/article/e3fd0e7cabdb43b7812e02e53fa58fcd
Autor:
Lucia Moreira, Abhijit Takawale, David A. Menassa, Constantinos Psarros, Neelam Mehta, Neil Evans, Marc-Antoine Gillis, Angela Lee, Patrice Naud, Mary Norris, Michele V. Clarke, Patricia K. Russell, Barbara Casadei, Shoumo Bhattacharya, Jeffrey D. Zajac, Rachel A. Davey, Martin Sirois, Rana Sayeed, George Krasopoulos, Charles Redwood, Keith Channon, Jean-Claud Tardif, Stanley Nattel, Svetlana Reilly
Publikováno v:
Journal of Molecular and Cellular Cardiology. 173:85-86
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ed4cbdefca5dbf58412e9643fb516cb
https://doi.org/10.1016/j.yjmcc.2022.08.171
https://doi.org/10.1016/j.yjmcc.2022.08.171
Autor:
Suketu Patel, Svetlana Reilly, Yin-Hua Zhang, Paul Robinson, Barbara Casadei, Hugh Watkins, Marta Malinowska, Alexander J Sparrow, Charles Redwood
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 319:H306-H319
Dilated cardiomyopathy (DCM) is clinically characterized by dilated ventricular cavities and reduced ejection fraction, leading to heart failure and increased thromboembolic risk. Mutations in thin-filament regulatory proteins can cause DCM and have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::caedfe5ac2f3d3635139dee4241620d7
https://doi.org/10.1152/ajpheart.00272.2020
https://doi.org/10.1152/ajpheart.00272.2020
Autor:
Stanislava V. Avrova, Vladimir V. Sirenko, Olga E. Karpicheva, Yurii S. Borovikov, Charles Redwood, Armen O. Simonyan
Publikováno v:
Biochemical and Biophysical Research Communications. 523:258-262
Ghost muscle fibres reconstituted with myosin heads labeled with the fluorescent probe 1,5-IAEDANS were used for analysis of muscle fibre dysfunction associated with the R133W mutation in β-tropomyosin (Tpm2.2). By using polarized microscopy, we sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a0b285e67cd493deae360e9c8e56b82
https://doi.org/10.1016/j.bbrc.2019.12.061
https://doi.org/10.1016/j.bbrc.2019.12.061