Zobrazeno 1 - 10 of 25 pro vyhledávání: '"Charles, RL"'
1
15-deoxy-Δ12,14-Prostaglandin J2 inhibits human soluble epoxide hydrolase by a dual orthosteric and allosteric mechanism
Autor: Abis, G, Charles, RL, Kopec, J, Yue, WW, Atkinson, RA, Bui, TTT, Lynham, S, Popova, S, Sun, Y-B, Fraternali, F, Eaton, P, Conte, MR
Publikováno v: Abis, G, Charles, R L, Kopec, J, Yue, W W, Atkinson, R A, Bui, T T T, Lynham, S, Popova, S, Sun, Y-B, Fraternali, F, Eaton, P & Conte, M R 2019, ' 15-deoxy-Δ 12,14-Prostaglandin J 2 inhibits human soluble epoxide hydrolase by a dual orthosteric and allosteric mechanism ', Communications Biology, vol. 2, no. 1, 188 . https://doi.org/10.1038/s42003-019-0426-2
Communications Biology
Communications Biology, Nature Publishing Group, 2019, 2 (1), ⟨10.1038/s42003-019-0426-2⟩
Communications Biology, Vol 2, Iss 1, Pp 1-14 (2019)
Human soluble epoxide hydrolase (hsEH) is an enzyme responsible for the inactivation of bioactive epoxy fatty acids, and its inhibition is emerging as a promising therapeutical strategy to target hypertension, cardiovascular disease, pain and insulin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::171ef5494cea0bc031d1c2b36730d56c
http://ora.ox.ac.uk/objects/uuid:
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3
Protein sulfenation as a redox sensor: proteomics studies using a novel biotinylated dimedone analogue
Autor: Charles, RL, Schröder, E, May, G, Free, P, Gaffney, PR, Wait, R, Begum, S, Heads, RJ, Eaton, P
Protein sulfenic acids are reactive intermediates in the catalytic cycles of many enzymes as well as the in formation of other redox states. Sulfenic acid formation is a reversible post-translational modification with potential for protein regulation
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::4e6378282a24e0d72bc76f7a1b1b9f3a
https://doi.org/10.1074/mcp.m700065-mcp200
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4
Akademický článek
Naked mole-rats have distinctive cardiometabolic and genetic adaptations to their underground low-oxygen lifestyles.
Autor: Faulkes CG; School of Biological and Behavioural Sciences, Fogg Building, Mile End Road, Queen Mary University of London, London, E1 4NS, UK., Eykyn TR; Department of Imaging Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, London, SE1 7EH, UK., Miljkovic JL; MRC Mitochondrial Biology Unit, University of Cambridge, Keith Peters Building, Cambridge, CB2 0XY, UK., Gilbert JD; School of Biological and Behavioural Sciences, Fogg Building, Mile End Road, Queen Mary University of London, London, E1 4NS, UK., Charles RL; Centre for Clinical Pharmacology and Precision Medicine, William Harvey Research Institute, Bart's and the London Faculty of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK., Prag HA; MRC Mitochondrial Biology Unit, University of Cambridge, Keith Peters Building, Cambridge, CB2 0XY, UK.; Department of Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK., Patel N; Centre for Biochemical Pharmacology, William Harvey Research Institute, Bart's and the London Faculty of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK., Hart DW; Department of Zoology and Entomology, Mammal Research Institute, University of Pretoria, Pretoria, 0002, South Africa., Murphy MP; MRC Mitochondrial Biology Unit, University of Cambridge, Keith Peters Building, Cambridge, CB2 0XY, UK., Bennett NC; Department of Zoology and Entomology, Mammal Research Institute, University of Pretoria, Pretoria, 0002, South Africa., Aksentijevic D; Centre for Biochemical Pharmacology, William Harvey Research Institute, Bart's and the London Faculty of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK. d.aksentijevic@qmul.ac.uk.
Publikováno v: Nature communications [Nat Commun] 2024 Mar 27; Vol. 15 (1), pp. 2204. Date of Electronic Publication: 2024 Mar 27.
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5
Akademický článek
A thiol redox sensor in soluble epoxide hydrolase enables oxidative activation by intra-protein disulfide bond formation.
Autor: Charles RL; Queen Mary University of London, William Harvey Research Institute, Charterhouse Square, London, EC1M 6BQ, UK., Abis G; King's College London, Randall Centre for Cell and Molecular Biophysics, School of Basic and Medical Biosciences, London, SE1 1UL, UK., Fernandez BF; King's College London, The British Heart Foundation Centre of Excellence, The Rayne Institute, St Thomas' Hospital, London, SE1 7EH, UK., Guttzeit S; King's College London, The British Heart Foundation Centre of Excellence, The Rayne Institute, St Thomas' Hospital, London, SE1 7EH, UK., Buccafusca R; Queen Mary University of London, School of Biological and Chemical Sciences, Mile End Road, London, E1 4NS, UK., Conte MR; King's College London, Randall Centre for Cell and Molecular Biophysics, School of Basic and Medical Biosciences, London, SE1 1UL, UK. Electronic address: sasi.conte@kcl.ac.uk., Eaton P; Queen Mary University of London, William Harvey Research Institute, Charterhouse Square, London, EC1M 6BQ, UK. Electronic address: p.eaton@qmul.ac.uk.
Publikováno v: Redox biology [Redox Biol] 2021 Oct; Vol. 46, pp. 102107. Date of Electronic Publication: 2021 Aug 18.
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6
Akademický článek
Ndufs2, a Core Subunit of Mitochondrial Complex I, Is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction.
Autor: Dunham-Snary KJ; From the Department of Medicine, Queen's University, Kingston, ON, Canada (K.J.D.-S., D.W., F.P., E.A.S., J.D.M., S.L.A.)., Wu D; From the Department of Medicine, Queen's University, Kingston, ON, Canada (K.J.D.-S., D.W., F.P., E.A.S., J.D.M., S.L.A.)., Potus F; From the Department of Medicine, Queen's University, Kingston, ON, Canada (K.J.D.-S., D.W., F.P., E.A.S., J.D.M., S.L.A.)., Sykes EA; From the Department of Medicine, Queen's University, Kingston, ON, Canada (K.J.D.-S., D.W., F.P., E.A.S., J.D.M., S.L.A.)., Mewburn JD; From the Department of Medicine, Queen's University, Kingston, ON, Canada (K.J.D.-S., D.W., F.P., E.A.S., J.D.M., S.L.A.)., Charles RL; British Heart Foundation Centre of Excellence, King´s College London, The Rayne Institute, St Thomas' Hospital, London, United Kingdom (R.L.C., P.E.)., Eaton P; British Heart Foundation Centre of Excellence, King´s College London, The Rayne Institute, St Thomas' Hospital, London, United Kingdom (R.L.C., P.E.)., Sultanian RA; Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada (R.A.S.)., Archer SL; From the Department of Medicine, Queen's University, Kingston, ON, Canada (K.J.D.-S., D.W., F.P., E.A.S., J.D.M., S.L.A.).; Queen's Cardiopulmonary Unit (QCPU), Translational Institute of Medicine (TIME), Department of Medicine, Queen's University, Kingston, ON, Canada (S.L.A.).
Publikováno v: Circulation research [Circ Res] 2019 Jun 07; Vol. 124 (12), pp. 1727-1746. Date of Electronic Publication: 2019 Mar 29.
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7
Akademický článek
15-deoxy-Δ 12,14 -Prostaglandin J 2 inhibits human soluble epoxide hydrolase by a dual orthosteric and allosteric mechanism.
Autor: Abis G; 1Randall Centre for Cell and Molecular Biophysics, School of Basic and Medical Biosciences, King's College London, London, SE1 1UL UK., Charles RL; 2School of Cardiovascular Medicine & Science, The Rayne Institute, Lambeth Wing, St Thomas' Hospital, King's College London, London, SE1 7EH UK., Kopec J; 3Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7DQ UK., Yue WW; 3Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7DQ UK., Atkinson RA; 1Randall Centre for Cell and Molecular Biophysics, School of Basic and Medical Biosciences, King's College London, London, SE1 1UL UK.; 4Centre for Biomolecular Spectroscopy, King's College London, London, SE1 1UL UK., Bui TTT; 1Randall Centre for Cell and Molecular Biophysics, School of Basic and Medical Biosciences, King's College London, London, SE1 1UL UK.; 4Centre for Biomolecular Spectroscopy, King's College London, London, SE1 1UL UK., Lynham S; 5Proteomics Facility, Centre of Excellence for Mass Spectrometry, The James Black Centre, King's College London, London, SE5 9NU UK., Popova S; 1Randall Centre for Cell and Molecular Biophysics, School of Basic and Medical Biosciences, King's College London, London, SE1 1UL UK., Sun YB; 1Randall Centre for Cell and Molecular Biophysics, School of Basic and Medical Biosciences, King's College London, London, SE1 1UL UK., Fraternali F; 1Randall Centre for Cell and Molecular Biophysics, School of Basic and Medical Biosciences, King's College London, London, SE1 1UL UK., Eaton P; 2School of Cardiovascular Medicine & Science, The Rayne Institute, Lambeth Wing, St Thomas' Hospital, King's College London, London, SE1 7EH UK., Conte MR; 1Randall Centre for Cell and Molecular Biophysics, School of Basic and Medical Biosciences, King's College London, London, SE1 1UL UK.; 4Centre for Biomolecular Spectroscopy, King's College London, London, SE1 1UL UK.
Publikováno v: Communications biology [Commun Biol] 2019 May 17; Vol. 2, pp. 188. Date of Electronic Publication: 2019 May 17 (Print Publication: 2019).
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8
Akademický článek
Earlier Physical Therapy Input Is Associated With a Reduced Length of Hospital Stay and Reduced Care Needs on Discharge in Frail Older Inpatients: An Observational Study.
Autor: Hartley PJ; Department of Physiotherapy, Addenbrooke's Hospital, Cambridge, United Kingdom., Keevil VL; Department of Medicine for the Elderly, Addenbrooke's Hospital, Cambridge, United Kingdom.; Clinical Gerontology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom., Alushi L; Department of Physiotherapy, Addenbrooke's Hospital, Cambridge, United Kingdom., Charles RL; Department of Physiotherapy, Addenbrooke's Hospital, Cambridge, United Kingdom., Conroy EB; Department of Physiotherapy, Addenbrooke's Hospital, Cambridge, United Kingdom., Costello PM; Department of Physiotherapy, Addenbrooke's Hospital, Cambridge, United Kingdom., Dixon B; Department of Physiotherapy, Addenbrooke's Hospital, Cambridge, United Kingdom., Dolinska-Grzybek AM; Department of Physiotherapy, Addenbrooke's Hospital, Cambridge, United Kingdom., Vajda D; Department of Physiotherapy, Addenbrooke's Hospital, Cambridge, United Kingdom., Romero-Ortuno R; Department of Medicine for the Elderly, Addenbrooke's Hospital, Cambridge, United Kingdom.; Clinical Gerontology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
Publikováno v: Journal of geriatric physical therapy (2001) [J Geriatr Phys Ther] 2019 Apr/Jun; Vol. 42 (2), pp. E7-E14.
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9
Akademický článek
Expression, purification, and characterisation of human soluble Epoxide Hydrolase (hsEH) and of its functional C-terminal domain.
Autor: Abis G; Randall Centre for Cell and Molecular Biophysics and British Heart Foundation Centre of Excellence, School of Basic and Medical Biosciences, King's College London, London, SE1 1UL, United Kingdom. Electronic address: giancarlo.abis@kcl.ac.uk., Charles RL; Cardiovascular Division and British Heart Foundation Centre of Excellence, The Rayne Institute, King´s College London, St Thomas' Hospital, London, SE1 7EH, United Kingdom., Eaton P; Cardiovascular Division and British Heart Foundation Centre of Excellence, The Rayne Institute, King´s College London, St Thomas' Hospital, London, SE1 7EH, United Kingdom., Conte MR; Randall Centre for Cell and Molecular Biophysics and British Heart Foundation Centre of Excellence, School of Basic and Medical Biosciences, King's College London, London, SE1 1UL, United Kingdom. Electronic address: sasi.conte@kcl.ac.uk.
Publikováno v: Protein expression and purification [Protein Expr Purif] 2019 Jan; Vol. 153, pp. 105-113. Date of Electronic Publication: 2018 Sep 12.
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10
Akademický článek
How and why we need to capture tacit knowledge in manufacturing: Case studies of visual inspection.
Autor: Johnson TL; Industrial Psychology and Human Factors Group, School of Aerospace, Transport and Manufacturing, Cranfield University, Bedford, MK43 0AL, UK. Electronic address: t.l.johnson@cranfield.ac.uk., Fletcher SR; Industrial Psychology and Human Factors Group, School of Aerospace, Transport and Manufacturing, Cranfield University, Bedford, MK43 0AL, UK., Baker W; Industrial Psychology and Human Factors Group, School of Aerospace, Transport and Manufacturing, Cranfield University, Bedford, MK43 0AL, UK., Charles RL; Industrial Psychology and Human Factors Group, School of Aerospace, Transport and Manufacturing, Cranfield University, Bedford, MK43 0AL, UK.
Publikováno v: Applied ergonomics [Appl Ergon] 2019 Jan; Vol. 74, pp. 1-9. Date of Electronic Publication: 2018 Aug 03.
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