P1433: POSITRON EMISSION TOMOGRAPHY IMAGING OF VLA-4 AS A NEW BIOMARKER OF VASO-OCCLUSION IN SICKLE CELL DISEASE

Autor: Qin Zhu, Lynda Little-Ihrig, Nishi Yadav, Joseph Latoche, Kathryn Day, Scott Mason, Charles Laymon, Sina Tavakoli, Carolyn Anderson, Enrico Novelli

Publikováno v: HemaSphere, Vol 7, p e58374e6 (2023)

Externí odkaz: https://doaj.org/article/26c385ba42e84a5c9da8fe53c5a52686

Maturation of the human striatal dopamine system revealed by PET and quantitative MRI

Autor: Bart Larsen, Valur Olafsson, Finnegan Calabro, Charles Laymon, Brenden Tervo-Clemmens, Elizabeth Campbell, Davneet Minhas, David Montez, Julie Price, Beatriz Luna

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)

How the human dopamine system changes during adolescence is still unclear. Here, the authors combine PET and quantitative MRI measures to show that dopamine D2/D3 receptor availability decreases with age while presynaptic dopamine vesicular storage w

Externí odkaz: https://doaj.org/article/558f3f172ed54c598928c89798f37901

Weight Loss and Alzheimer's Disease in Down Syndrome

Autor: Victoria, Fleming, Brian C, Helsel, Lauren T, Ptomey, H Diana, Rosas, Benjamin, Handen, Charles, Laymon, Bradley T, Christian, Elizabeth, Head, Mark, Mapstone, Florence, Lai, Sharon, Krinsky-McHale, Shahid, Zaman, Beau M, Ances, Joseph H, Lee, Sigan L, Hartley

Publikováno v: Journal of Alzheimer's disease : JAD.

Virtually all adults with Down syndrome (DS) develop Alzheimer's disease (AD) pathology, but research gaps remain in understanding early signs of AD in DS.The goal of the present study was to determine if unintentional weight loss is part of AD in DS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::865b4973fb7a9b4c77a4f186331d4a3b
https://pubmed.ncbi.nlm.nih.gov/36565120

Comparison of amyloid burden in individuals with Down syndrome versus autosomal dominant Alzheimer's disease: a cross-sectional study

Autor: Anna H Boerwinkle, Brian A Gordon, Julie Wisch, Shaney Flores, Rachel L Henson, Omar H Butt, Nicole McKay, Charles D Chen, Tammie L S Benzinger, Anne M Fagan, Benjamin L Handen, Bradley T Christian, Elizabeth Head, Mark Mapstone, Michael S Rafii, Sid O'Bryant, Florence Lai, H Diana Rosas, Joseph H Lee, Wayne Silverman, Adam M Brickman, Jasmeer P Chhatwal, Carlos Cruchaga, Richard J Perrin, Chengjie Xiong, Jason Hassenstab, Eric McDade, Randall J Bateman, Beau M Ances, Howard J Aizenstein, Howard F Andrews, Karen Bell, Rasmus M Birn, Peter Bulova, Amrita Cheema, Kewei Chen, Isabel Clare, Lorraine Clark, Ann D Cohen, John N Constantino, Eric W Doran, Eleanor Feingold, Tatiana M Foroud, Sigan L Hartley, Christy Hom, Lawrence Honig, Milos D Ikonomovic, Sterling C Johnson, Courtney Jordan, M Ilyas Kamboh, David Keator, William E Klunk MD, Julia K Kofler, William C Kreisl, Sharon J Krinsky- McHale, Patrick Lao, Charles Laymon, Ira T Lott, Victoria Lupson, Chester A Mathis, Davneet S Minhas, Neelesh Nadkarni, Deborah Pang, Melissa Petersen, Julie C Price, Margaret Pulsifer, Eric Reiman, Batool Rizvi, Marwan N Sabbagh, Nicole Schupf, Dana L Tudorascu, Rameshwari Tumuluru, Benjamin Tycko, Badri Varadarajan, Desiree A White, Michael A Yassa, Shahid Zaman, Fan Zhang, Sarah Adams, Ricardo Allegri, Aki Araki, Nicolas Barthelemy, Jacob Bechara, Sarah Berman, Courtney Bodge, Susan Brandon, William Brooks, Jared Brosch, Jill Buck, Virginia Buckles, Kathleen Carter, Lisa Cash, Patricio C Mendez, Jasmin Chua, Helena Chui, Laura Courtney, Gregory Day, Chrismary DeLaCruz, Darcy Denner, Anna Diffenbacher, Aylin Dincer, Tamara Donahue, Jane Douglas, Duc Duong, Noelia Egido, Bianca Esposito, Marty Farlow, Becca Feldman, Colleen Fitzpatrick, Nick Fox, Erin Franklin, Nelly Joseph-Mathurin, Hisako Fujii, Samantha Gardener, Bernardino Ghetti, Alison Goate, Sarah Goldberg, Jill Goldman, Alyssa Gonzalez, Susanne Gräber-Sultan, Neill Graff-Radford, Morgan Graham, Julia Gray, Emily Gremminger, Miguel Grilo, Alex Groves, Christian Haass, Lisa Häslerc, Cortaiga Hellm, Elizabeth Herries, Laura Hoechst-Swisher, Anna Hofmann, David Holtzman, Russ Hornbeck, Yakushev Igor, Ryoko Ihara, Takeshi Ikeuchi, Snezana Ikonomovic, Kenji Ishii, Clifford Jack, Gina Jerome, Erik Johnson, Mathias Jucker, Celeste Karch, Stephan Käser, Kensaku Kasuga, Sarah Keefe, William Klunk, Robert Koeppe, Deb Koudelis, Elke Kuder-Buletta, Christoph Laske, Allan Levey, Johannes Levin, Yan Li, Oscar Lopez, Jacob Marsh, Ralph Martins, Neal S Mason, Colin Masters, Kwasi Mawuenyega, Austin McCullough, Arlene Mejia, Estrella Morenas-Rodriguez, John C Morris, James Mountz, Catherine Mummery, Akemi Nagamatsu, Katie Neimeyer, Yoshiki Niimi, James Noble, Joanne Norton, Brigitte Nuscher, Ulricke Obermüller, Antoinette O'Connor, Riddhi Patira, Lingyan Ping, Oliver Preische, Alan Renton, John Ringman, Stephen Salloway, Peter Schofield, Michio Senda, Nicholas T Seyfried, Kristine Shady, Hiroyuki Shimada, Wendy Sigurdson, Jennifer Smith, Lori Smith, Beth Snitz, Hamid Sohrabi, Sochenda Stephens, Kevin Taddei, Sarah Thompson, Jonathan Vöglein, Peter Wang, Qing Wang, Elise Weamer, Jinbin Xu, Xiong Xu

Publikováno v: The Lancet. Neurology. 22(1)

Important insights into the early pathogenesis of Alzheimer's disease can be provided by studies of autosomal dominant Alzheimer's disease and Down syndrome. However, it is unclear whether the timing and spatial distribution of amyloid accumulation d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d7393e6ae67adf1894641c909a5e896
https://pubmed.ncbi.nlm.nih.gov/36517172

Quantifying metabolic heterogeneity in head and neck tumors in real time: 2-DG uptake is highest in hypoxic tumor regions.

Autor: Erica C Nakajima, Charles Laymon, Matthew Oborski, Weizhou Hou, Lin Wang, Jennifer R Grandis, Robert L Ferris, James M Mountz, Bennett Van Houten

Publikováno v: PLoS ONE, Vol 9, Iss 8, p e102452 (2014)

PURPOSE:Intratumoral metabolic heterogeneity may increase the likelihood of treatment failure due to the presence of a subset of resistant tumor cells. Using a head and neck squamous cell carcinoma (HNSCC) xenograft model and a real-time fluorescence

Externí odkaz: https://doaj.org/article/4b81cfef71f341b4936a1a565acd080f