Zobrazeno 1 - 10
of 257
pro vyhledávání: '"Charles, Keller"'
Autor:
Shefali Chauhan, Emily Lian, Iman Habib, Qianqian Liu, Nicole M. Anders, Megan M. Bugg, Noah C. Federman, Joel M. Reid, Clinton F. Stewart, Tristan Cates, Joel E. Michalek, Charles Keller
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Rhabdomyosarcoma (RMS) is the most common childhood soft tissue sarcoma. For the alveolar subtype (ARMS), the presence of the PAX3::FOXO1 fusion gene and/or metastases are strong predictors of poor outcome. Metastatic PAX3::FOXO1 + ARMS ofte
Externí odkaz:
https://doaj.org/article/f0d777b3277b40b58dcedcf300719a97
Autor:
Jin-Ah Kim, Kenneth A. Crawford, Piero A. Spada, Leah R. Martin, Jiaqi Zhang, Rain Wong, Joel M. Reid, Clinton F. Stewart, Timothy M. Frank, Qianqian Liu, Joel E. Michalek, Charles Keller
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Ewing sarcoma (EWS) is a malignant tumor arising in bone or soft tissue that occurs in adolescent and young adult patients as well as adults later in life. Although non-metastatic EWS is typically responsive to treatment when newly diagnosed
Externí odkaz:
https://doaj.org/article/e3bdb641aa15428894c65e7b7a142c51
Autor:
Marcus O. Muench, Marina E. Fomin, Alan G. Gutierrez, Dolores López-Terrada, Renata Gilfanova, Christopher Nosworthy, Ashley I. Beyer, Gregory Ostolaza, Dina Kats, Kevin L. Matlock, Stefano Cairo, Charles Keller
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Background & AimsHepatocytic cells found during prenatal development have unique features compared to their adult counterparts, and are believed to be the precursors of pediatric hepatoblastoma. The cell-surface phenotype of hepatoblasts and hepatobl
Externí odkaz:
https://doaj.org/article/a37e0996fedf4aec9268047863647657
Autor:
Samuel V. Rasmussen, Noah E. Berlow, Lisa Hudson Price, Atiya Mansoor, Stefano Cairo, Sandra Rugonyi, Charles Keller
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract Preclinical cancer research ranges from in vitro studies that are inexpensive and not necessarily reflective of the tumor microenvironment to mouse studies that are better models but prohibitively expensive at scale. Chorioallantoic membrane
Externí odkaz:
https://doaj.org/article/01643ff53c1b43ab8f9b56e7125517f1
Autor:
Samuel V. Rasmussen, Jia xiang Jin, Lissett R. Bickford, Andrew D. Woods, Felix Sahm, Kenneth A. Crawford, Kiyo Nagamori, Hiroaki Goto, Keila E. Torres, Angelo Sidoni, Erin R. Rudzinski, Khin Thway, Robin L. Jones, Alessio Ciulli, Hollis Wright, Melvin Lathara, Ganapati Srinivasa, Kavya Kannan, Paul H. Huang, Thomas G. P. Grünewald, Noah E. Berlow, Charles Keller
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 7, Pp n/a-n/a (2022)
Abstract Background Metastatic epithelioid sarcoma (EPS) remains a largely unmet clinical need in children, adolescents and young adults despite the advent of EZH2 inhibitor tazemetostat. Methods In order to realise consistently effective drug therap
Externí odkaz:
https://doaj.org/article/a9d6193aa8f1420093d421068a8cd0a1
Autor:
Xiaolei Lian, Dina Kats, Samuel Rasmussen, Leah R. Martin, Anju Karki, Charles Keller, Noah E. Berlow
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-12 (2021)
Abstract Diffuse intrinsic pontine glioma (DIPG), a rare pediatric brain tumor, afflicts approximately 350 new patients each year in the United States. DIPG is noted for its lethality, as fewer than 1% of patients survive to five years. Multiple clin
Externí odkaz:
https://doaj.org/article/26cfaf7f458f4996ac8ece720aa85a1a
Autor:
Anju Karki, Reshma Purohit, Sofia Tosoni, Narendra Bharathy, Joel E Michalek, Sonja Chen, Charles Keller
Publikováno v:
Sarcoma, Vol 2022 (2022)
Rhabdomyosarcoma (RMS) is the most common pediatric soft tissue sarcoma for which subsets of patients have longstanding unmet clinical needs. For example, children with alveolar rhabdomyosarcoma and metastases at diagnosis will experience only 8% dis
Externí odkaz:
https://doaj.org/article/be5db5bc05c440ce8f445ad3fc16add2
Autor:
Shefali Chauhan, Andrew D. Woods, Narendra Bharathy, Xiaolei Lian, Cora A. Ricker, Amy Mantz, William J. Zuercher, Lisa H. Price, Michael J. Morton, Eric Durrant, Stéphane Y. Corbel, Srinath C. Sampath, Srihari C. Sampath, John Joslin, Charles Keller
Publikováno v:
Biochemical and Biophysical Research Communications. 667:138-145
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5495e2cf41b464d773d5fa7ec301e49
https://doi.org/10.1016/j.bbrc.2023.04.114
https://doi.org/10.1016/j.bbrc.2023.04.114
Autor:
Noah E. Berlow, Rishi Rikhi, Mathew Geltzeiler, Jinu Abraham, Matthew N. Svalina, Lara E. Davis, Erin Wise, Maria Mancini, Jonathan Noujaim, Atiya Mansoor, Michael J. Quist, Kevin L. Matlock, Martin W. Goros, Brian S. Hernandez, Yee C. Doung, Khin Thway, Tomohide Tsukahara, Jun Nishio, Elaine T. Huang, Susan Airhart, Carol J. Bult, Regina Gandour-Edwards, Robert G. Maki, Robin L. Jones, Joel E. Michalek, Milan Milovancev, Souparno Ghosh, Ranadip Pal, Charles Keller
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-23 (2019)
Abstract Background Cancer patients with advanced disease routinely exhaust available clinical regimens and lack actionable genomic medicine results, leaving a large patient population without effective treatments options when their disease inevitabl
Externí odkaz:
https://doaj.org/article/6013cd28c33a417d9d673beb4af0154c
Autor:
Daniel Beltrán, Mary E. Anderson, Narendra Bharathy, Teagan P. Settelmeyer, Matthew N. Svalina, Zia Bajwa, John F. Shern, Sakir H. Gultekin, Marco A. Cuellar, Takahiro Yonekawa, Charles Keller, Kevin P. Campbell
Publikováno v:
Skeletal Muscle, Vol 9, Iss 1, Pp 1-10 (2019)
Abstract Background α-Dystroglycan is the highly glycosylated component of the dystrophin-glycoprotein complex (DGC) that binds with high-affinity to extracellular matrix (ECM) proteins containing laminin-G-like (LG) domains via a unique heteropolys
Externí odkaz:
https://doaj.org/article/7072103e912f4551afb57f3116e9e911