Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Charles, Goodacre"'
Autor:
Gary Goldstein, Charles Goodacre
Publikováno v:
Journal of Prosthodontics. 32:10-17
The ever-expanding world of digital technology has produced many changes, including the availability of virtual articulators. The use of such digital technology requires an understanding of the features that have been available with different mechani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::843237fc5997a1a66ec5b32a48a03c20
https://doi.org/10.1111/jopr.13517
https://doi.org/10.1111/jopr.13517
Autor:
Kuen Yeap, John S. Wai, Maia Vinogradova, Yu Zhong, Lori Friedman, Xiaojing Wang, Daniel Otwine, Jiangpeng Liao, Nick Ray, James R. Kiefer, Vidhi Mody, Jun Li, Fabien Roussel, Deepak Sampath, Simon Charles Goodacre, Jun Liang, Michelle Nannini, Sharada Labadie, Xiaoping Zheng, Ellen Ingalla, Steven J. Hartman, Birong Zhang, Jae H. Chang, Tao Wang, Yingqing Ran, Jason R. Zbieg, Amy Sambrone, Kwong Wah Lai, Amy Young, Ciara Metcalfe, Neville James Mclean, Robert A. Blake, Tracy Kleinheinz
Publikováno v:
ACS Med Chem Lett
[Image: see text] Estrogen receptor alpha (ERα) is a well-validated drug target for ER-positive (ER+) breast cancer. Fulvestrant is FDA-approved to treat ER+ breast cancer and works through two mechanisms—as a full antagonist and selective estroge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe42f6062f9f361a3f700a527fd2a8dc
https://doi.org/10.1021/acsmedchemlett.0c00224
https://doi.org/10.1021/acsmedchemlett.0c00224
Autor:
Martin O'Rourke, Nicholas Charles Ray, Thomas Gelzleichter, Leah Schutt, Ellen Ingalla, Neville James Mclean, Xiaojing Wang, Stephen Daly, Yingqing Ran, Jiangpeng Liao, Tommy Lai, Yu Zhong, Jun Liang, Sharada Labadie, Lori Friedman, Amy Sambrone, Jun Li, Robert A. Blake, Tao Wang, Liu Zhiguo, Birong Zhang, Steven J. Hartman, Jae H. Chang, Wei Zhou, Jane Guan, Vidhi Mody, Jonathan White, Fabien Roussel, Antonio G. DiPasquale, Jason R. Zbieg, Daniel F. Ortwine, Amy Young, James R. Kiefer, Maia Vinogradova, Simon Charles Goodacre, Deepak Sampath, Tracy Kleinheinz, Xiaoping Zheng, Jennifer M. Giltnane, Lorn Kategaya, Ingrid E. Wertz, Matthew Gill, Ciara Metcalfe, Siew Kuen Yeap, John S. Wai, Jason Oeh, Michelle Nannini
Publikováno v:
Journal of medicinal chemistry. 64(16)
Breast cancer remains a leading cause of cancer death in women, representing a significant unmet medical need. Here, we disclose our discovery efforts culminating in a clinical candidate, 35 (GDC-9545 or giredestrant). 35 is an efficient and potent s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee86fe3f8068fbb2ff9647a59eadb710
https://pubmed.ncbi.nlm.nih.gov/34251202
https://pubmed.ncbi.nlm.nih.gov/34251202
Autor:
Xingrong Liu, Nico Ghilardi, Simon Charles Goodacre, Michael Siu, Jim Nonomiya, G. Buckley, Adam R. Johnson, Yun-Xing Cheng, F.A. Romero, Nick Ray, Rohan Mendonca, C. Robinson, Yuen Po-Wai, Jane R. Kenny, Marya Liimatta, Terry Kellar, Mark Zak, Gary Salmon, J. Lloyd, D.G. Brown, Neville James Mclean, Joseph P. Lyssikatos, Emily J. Hanan, Patrick J. Lupardus, Pawan Bir Kohli, Christopher A. Hurley, Guiling Zhao, Paul Gibbons, Peter H. Crackett
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:1522-1531
Disruption of interleukin-13 (IL-13) signaling with large molecule antibody therapies has shown promise in diseases of allergic inflammation. Given that IL-13 recruits several members of the Janus Kinase family (JAK1, JAK2, and TYK2) to its receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5e867a785065ce94ed8447c01ad10c0
https://doi.org/10.1016/j.bmcl.2019.04.008
https://doi.org/10.1016/j.bmcl.2019.04.008
Autor:
Kuen Yeap, Birong Zhang, Jae H. Chang, Lori Friedman, Nick Ray, Jiangpeng Liao, Xiaojing Wang, Amy Sambrone, Jun Li, Yu Zhong, Ellen Ingalla, Jason R. Zbieg, Daniel F. Ortwine, Vidhi Mody, John S. Wai, Tao Wang, Maia Vinogradova, Sharada Labadie, Steven J. Hartman, Tracy Kleinheinz, Nev McLean, Tommy Lai, Simon Charles Goodacre, Deepak Sampath, Jun Liang, Fabien Roussel, James R. Kiefer, Ciara Metcalfe, Xiaoping Zheng, Yingqing Ran, Michelle Nannini, Robert A. Blake
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 50:128335
Fulvestrant is an FDA-approved drug with a dual mechanism of action (MOA), acting as a full antagonist and degrader of the estrogen receptor protein. A significant limitation of fulvestrant is the dosing regimen required for efficacy. Due to its high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c4ca868520e02822732a1114f5f125c
https://doi.org/10.1016/j.bmcl.2021.128335
https://doi.org/10.1016/j.bmcl.2021.128335
Autor:
Tomas, Albrektsson, Charles, Goodacre, Reinhilde, Jacobs, Waseem, Jerjes, Anke, Korfage, Christel, Larsson, Friedrich, Neukam, Mark, Packer, Bernhard, Pommer, Daniel, van Steenberghe, Analia, Veitz-Keenan, Ann, Wennerberg
Publikováno v:
European journal of oral implantology. 11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3553fa4d89548d59aa3546048bd12b0f
https://pubmed.ncbi.nlm.nih.gov/30109294
https://pubmed.ncbi.nlm.nih.gov/30109294
Autor:
Stephen Schmidt, Kevin R Clark, Joseph P. Lyssikatos, Brent A. Appleton, Joy Drobnick, Huifen Chen, Christian Wiesmann, Kerry Chapman, Jason Halladay, Ivana Yen, Ping Wu, Lewis J. Gazzard, Simon Charles Goodacre, Steve Sideris, Shiva Malek, Karen Williams
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:5704-5709
Checkpoint kinase 1 (ChK1) is activated in response to DNA damage, acting to temporarily block cell cycle progression and allow for DNA repair. It is envisaged that inhibition of ChK1 will sensitize tumor cells to treatment with DNA-damaging therapie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79ab92dabfac7006eb7c98b64e04605b
https://doi.org/10.1016/j.bmcl.2014.10.063
https://doi.org/10.1016/j.bmcl.2014.10.063
Autor:
Leo Berezhkovsky, Mark Ultsch, Jan Smith, Wade S. Blair, Adam R. Johnson, Calum Macleod, Simon Charles Goodacre, Jason DeVoss, Jun Liang, Kapil Menghrajani, Jim Driscoll, Nico Ghilardi, Wenqian Yang, Steven Magnuson, Karen Williams, Anne van Abbema, Donnie Delarosa, Pawan Bir Kohli, Hieu Nguyen, Kathy Barrett, Steven Shia, Birong Zhang, Sue Sohn, Zhonghua Lin, Christine Chang, Mercedesz Balazs, Priscilla Mantik, Yingjie Lai, Charles Eigenbrot, Vickie Tsui, Amy Sambrone, Ivan Peng, Lawren C. Wu
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(18)
Herein we report identification of an imidazopyridine class of potent and selective TYK2 inhibitors, exemplified by prototype 6, through constraint of the rotatable amide bond connecting the pyridine and aryl rings of compound 1. Further optimization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ddf2968327d5cbe784ea14d2b0f7a5d
https://pubmed.ncbi.nlm.nih.gov/28830649
https://pubmed.ncbi.nlm.nih.gov/28830649
Autor:
John Liu, Stephanie Addo, Gauri Deshmukh, Wyne P. Lee, Mark Zak, Ivan Peng, Hart S. Dengler, Julia Lloyd, Simon Charles Goodacre, Nicholas Charles Ray, Eric Suto, Pawan Bir Kohli, Savita Ubhayakar, Cristine M. Quiason-Huynh, Xiumin Wu, Cornelia H. Rinderknecht, Sheerin K. Shahidi-Latham, Youngsu Kwon, Marya Liimatta, Janet Jackman, Gary Cain, Jane R. Kenny, Gary Salmon, Brent S. McKenzie, Mike Briggs, Adam R. Johnson, Kathy Barrett, Nico Ghilardi
Publikováno v:
Science translational medicine. 10(468)
Preclinical and clinical evidence indicates that a subset of asthma is driven by type 2 cytokines such as interleukin-4 (IL-4), IL-5, IL-9, and IL-13. Additional evidence predicts pathogenic roles for IL-6 and type I and type II interferons. Because
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e75f088b1fe1e780a2e75c42e77ea103
https://pubmed.ncbi.nlm.nih.gov/30463918
https://pubmed.ncbi.nlm.nih.gov/30463918
Publikováno v:
Journal of the California Dental Association. 41:47-50
It is hypothesized that use of an angulation sensor could increase the alignment accuracy of multiple implant osteotomies without requiring the use of guided-surgical templates. Therefore, the purpose of this study was to determine if use of such a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc264d4ab498af2f378ae78ce5f8712c
https://doi.org/10.1080/19424396.2013.12222278
https://doi.org/10.1080/19424396.2013.12222278