Zobrazeno 1 - 10
of 402
pro vyhledávání: '"Charles, Brenner"'
Autor:
Giorgio Turconi, Farhan Alam, Tanima SenGupta, Sini Pirnes-Karhu, Soophie Olfat, Mark S. Schmidt, Kärt Mätlik, Ana Montaño-Rodriguez, Vladimir Heiskanen, Daniel Garton, Petteri T. Piepponen, Charles Brenner, Carina I. Holmberg, Hilde Nilsen, Eija Pirinen, Jaan-Olle Andressoo
Publikováno v:
Heliyon, Vol 10, Iss 14, Pp e34355- (2024)
Parkinson's disease (PD) is associated with a reduction in 26/20S proteasome and mitochondrial function and depletion of dopamine. Activation of mitochondrial function with the NAD+ precursor nicotinamide riboside (NR) is a potential therapeutic for
Externí odkaz:
https://doaj.org/article/ac4f73d8f115461db81a3d5dd4a624da
Autor:
Esther P. Jane, Matthew C. Reslink, Taylor A. Gatesman, Matthew E. Halbert, Tracy A. Miller, Brian J. Golbourn, Stephanie M. Casillo, Steven J. Mullett, Stacy G. Wendell, Udochukwu Obodo, Dinesh Mohanakrishnan, Riya Dange, Antony Michealraj, Charles Brenner, Sameer Agnihotri, Daniel R. Premkumar, Ian F. Pollack
Publikováno v:
Molecular Oncology, Vol 17, Iss 9, Pp 1821-1843 (2023)
In previous studies, we demonstrated that panobinostat, a histone deacetylase inhibitor, and bortezomib, a proteasomal inhibitor, displayed synergistic therapeutic activity against pediatric and adult high‐grade gliomas. Despite the remarkable init
Externí odkaz:
https://doaj.org/article/855c1c665c7544d3830b200c1e512815
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
Alzheimer’s Disease (AD) is an aging-associated neurodegenerative disorder, threatening millions of people worldwide. The onset and progression of AD can be accelerated by environmental risk factors, such as bacterial and viral infections. Human he
Externí odkaz:
https://doaj.org/article/114215e6c3e5470b879f41dd699fc47b
Publikováno v:
Frontiers in Oncology, Vol 12 (2023)
IntroductionCancer inequity is one of the most critical public health issues faced by ethnic minorities and people of lower socioeconomic status. The disparate burden of cancer is caused by poor access to care and inadequate delivery of cancer treatm
Externí odkaz:
https://doaj.org/article/6aff0d9acb704c89b82c79d5e39cc2cd
Autor:
Jin‐Young Yoon, Nastaran Daneshgar, Yi Chu, Biyi Chen, Marco Hefti, Ajit Vikram, Kaikobad Irani, Long‐Sheng Song, Charles Brenner, E. Dale Abel, Barry London, Dao‐Fu Dai
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 7, Pp n/a-n/a (2022)
Abstract Background Mice with deletion of complex I subunit Ndufs4 develop mitochondrial encephalomyopathy resembling Leigh syndrome (LS). The metabolic derangement and underlying mechanisms of cardio‐encephalomyopathy in LS remains incompletely un
Externí odkaz:
https://doaj.org/article/9fc05873d4fb4a8a92652c0c9b8bc8e0
Publikováno v:
Hepatology Communications, Vol 4, Iss 8, Pp 1183-1192 (2020)
Nicotinamide adenine dinucleotide (NAD+) and related coenzymes play critical roles in liver function. Although hepatic alcohol metabolism depresses NAD+, current understanding of the NAD+ metabolome in alcohol‐related liver disease (ArLD) is based
Externí odkaz:
https://doaj.org/article/9622d91b05be4fa88bab879571d8c63c
Autor:
Maria Gerasimenko, Stanislav M. Cherepanov, Kazumi Furuhara, Olga Lopatina, Alla B. Salmina, Anna A. Shabalova, Chiharu Tsuji, Shigeru Yokoyama, Katsuhiko Ishihara, Charles Brenner, Haruhiro Higashida
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Abstract Oxytocin (OT) is a critical molecule for social recognition and memory that mediates social and emotional behaviours. In addition, OT acts as an anxiolytic factor and is released during stress. Based on the activity of CD38 as an enzyme that
Externí odkaz:
https://doaj.org/article/e2c0923f4072493b8dda2df22fce9bb6
Autor:
Jing Wu, Komudi Singh, Amy Lin, Allison M. Meadows, Kaiyuan Wu, Vivian Shing, Maximilian Bley, Shahin Hassanzadeh, Rebecca D. Huffstutler, Mark S. Schmidt, Luz P. Blanco, Rong Tian, Charles Brenner, Mehdi Pirooznia, Mariana J. Kaplan, Michael N. Sack
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 5 (2022)
BACKGROUND Fasting and NAD+-boosting compounds, including NAD+ precursor nicotinamide riboside (NR), confer antiinflammatory effects. However, the underlying mechanisms and therapeutic potential are incompletely defined.METHODS We explored the underl
Externí odkaz:
https://doaj.org/article/a5920c2523044c81b76b48c3c78216ac
Autor:
Nathan R. Fons, Ranjini K. Sundaram, Gregory A. Breuer, Sen Peng, Ryan L. McLean, Aravind N. Kalathil, Mark S. Schmidt, Diana M. Carvalho, Alan Mackay, Chris Jones, Ángel M. Carcaboso, Javad Nazarian, Michael E. Berens, Charles Brenner, Ranjit S. Bindra
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Mutations in the Protein Phosphatase PPM1D are oncogenic in certain cancers including diffuse intrinsic pontine glioma (DIPG). Here, the authors show that PPM1D mutations in DIPG induce the silencing of the nicotinic acid phosphoribosyltransferase ge
Externí odkaz:
https://doaj.org/article/cc9d2729a55c414fbabbdf50c1cccd2e
Autor:
Rachel S. Fletcher, Joanna Ratajczak, Craig L. Doig, Lucy A. Oakey, Rebecca Callingham, Gabriella Da Silva Xavier, Antje Garten, Yasir S. Elhassan, Philip Redpath, Marie E. Migaud, Andrew Philp, Charles Brenner, Carles Canto, Gareth G. Lavery
Publikováno v:
Molecular Metabolism, Vol 6, Iss 8, Pp 819-832 (2017)
Objective: Augmenting nicotinamide adenine dinucleotide (NAD+) availability may protect skeletal muscle from age-related metabolic decline. Dietary supplementation of NAD+ precursors nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) ap
Externí odkaz:
https://doaj.org/article/31c59e382804472ca4d15f33085dd592