Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Charlene Chan"'
Autor:
Hayden Weng Siong Tan, Guang Lu, Han Dong, Yik-Lam Cho, Auginia Natalia, Liming Wang, Charlene Chan, Dennis Kappei, Reshma Taneja, Shuo-Chien Ling, Huilin Shao, Shih-Yin Tsai, Wen-Xing Ding, Han-Ming Shen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The mechanisms underlying mitochondrial quality control are not fully understood. Here the authors identify a switch from degradative to secretory autophagy in the absence of the mATG8-conjugation system, termed Autophagic Secretion of Mitochondria.
Externí odkaz:
https://doaj.org/article/5faa98dd54e74eb38a71aec60636557b
Autor:
Emily Nicole Powers, Charlene Chan, Ella Doron-Mandel, Lidia Llacsahuanga Allcca, Jenny Kim Kim, Marko Jovanovic, Gloria Ann Brar
Publikováno v:
eLife, Vol 11 (2022)
Targeted selection-based genome-editing approaches have enabled many fundamental discoveries and are used routinely with high precision. We found, however, that replacement of DBP1 with a common selection cassette in budding yeast led to reduced expr
Externí odkaz:
https://doaj.org/article/b49a305637df4f8ebc5d04dbf3a11760
Autor:
Nisha Padmanabhan, Huang Kie Kyon, Arnoud Boot, Kevin Lim, Supriya Srivastava, Shuwen Chen, Zhiyuan Wu, Hyung-O K Lee, Vineeth T. Mukundan, Charlene Chan, Yarn Kit Chan, Ong Xuewen, Jason J. Pitt, Zul Fazreen Adam Isa, Manjie Xing, Ming Hui Lee, Angie Lay Keng Tan, Shamaine Ho Wei Ting, Micah A. Luftig, Dennis Kappei, Warren D. Kruger, Jinsong Bian, Ying Swan Ho, Ming Teh, Steve George Rozen, Patrick Tan
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-29 (2021)
Abstract Background CIMP (CpG island methylator phenotype) is an epigenetic molecular subtype, observed in multiple malignancies and associated with the epigenetic silencing of tumor suppressors. Currently, for most cancers including gastric cancer (
Externí odkaz:
https://doaj.org/article/9fe03d39024a4581867a3f4455dc22c4
Autor:
Kie Kyon Huang, Jiawen Huang, Jeanie Kar Leng Wu, Minghui Lee, Su Ting Tay, Vikrant Kumar, Kalpana Ramnarayanan, Nisha Padmanabhan, Chang Xu, Angie Lay Keng Tan, Charlene Chan, Dennis Kappei, Jonathan Göke, Patrick Tan
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-24 (2021)
Abstract Background Deregulated gene expression is a hallmark of cancer; however, most studies to date have analyzed short-read RNA sequencing data with inherent limitations. Here, we combine PacBio long-read isoform sequencing (Iso-Seq) and Illumina
Externí odkaz:
https://doaj.org/article/3769f999db7f45c5ba41d9dc617249e6
Autor:
Tin Chanh Pham, Migara Kavishka Jayasinghe, Thach Tuan Pham, Yuqi Yang, Likun Wei, Waqas Muhammad Usman, Huan Chen, Marco Pirisinu, Jinhua Gong, Seongkyeol Kim, Boya Peng, Weixi Wang, Charlene Chan, Victor Ma, Nhung T.H. Nguyen, Dennis Kappei, Xuan‐Hung Nguyen, William C. Cho, Jiahai Shi, Minh T.N. Le
Publikováno v:
Journal of Extracellular Vesicles, Vol 10, Iss 4, Pp n/a-n/a (2021)
Abstract Natural extracellular vesicles (EVs) are ideal drug carriers due to their remarkable biocompatibility. Their delivery specificity can be achieved by the conjugation of targeting ligands. However, existing methods to engineer target‐specifi
Externí odkaz:
https://doaj.org/article/518322fae98b458db70269039c3c2304
Autor:
David W Morgens, Charlene Chan, Andrew J Kane, Nicholas R Weir, Amy Li, Michael M Dubreuil, C Kimberly Tsui, Gaelen T Hess, Adam Lavertu, Kyuho Han, Nicole Polyakov, Jing Zhou, Emma L Handy, Philip Alabi, Amanda Dombroski, David Yao, Russ B Altman, Jason K Sello, Vladimir Denic, Michael C Bassik
Publikováno v:
eLife, Vol 8 (2019)
The small molecule Retro-2 prevents ricin toxicity through a poorly-defined mechanism of action (MOA), which involves halting retrograde vesicle transport to the endoplasmic reticulum (ER). CRISPRi genetic interaction analysis revealed Retro-2 activi
Externí odkaz:
https://doaj.org/article/f8b0b64eb9da49ff8b1b2ae4b6712fa1
Autor:
Aaron R. D’Souza, Dhivya Jayaraman, Ziqi Long, Jingwei Zeng, Liam J. Prestwood, Charlene Chan, Dennis Kappei, Andrew M. L. Lever, Julia C. Kenyon
Publikováno v:
Viruses, Vol 13, Iss 12, p 2389 (2021)
HIV-1 packages two copies of its gRNA into virions via an interaction with the viral structural protein Gag. Both copies and their native RNA structure are essential for virion infectivity. The precise stepwise nature of the packaging process has not
Externí odkaz:
https://doaj.org/article/f334a79e6870445aa2d9c87e59dd058b
Autor:
Nisha Padmanabhan, Huang Kie Kyon, Arnoud Boot, Kevin Lim, Supriya Srivastava, Shuwen Chen, Zhiyuan Wu, Hyung-Ok Lee, Vineeth T. Mukundan, Charlene Chan, Yarn Kit Chan, Ong Xuewen, Jason J. Pitt, Zul Fazreen Adam Isa, Manjie Xing, Ming Hui Lee, Angie Lay Keng Tan, Shamaine Ho Wei Ting, Micah A. Luftig, Dennis Kappei, Warren D. Kruger, Jinsong Bian, Ying Swan Ho, Ming Teh, Steve George Rozen, Patrick Tan
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/a15ba86b39964ee19473ec85a8dc3eb7
Publikováno v:
Cell Reports, Vol 20, Iss 10, Pp 2287-2293 (2017)
The Get1/2 transmembrane complex drives the insertion of tail-anchored (TA) proteins from the cytosolic chaperone Get3 into the endoplasmic reticulum membrane. Mechanistic insight into how Get1/2 coordinates this process is confounded by a lack of un
Externí odkaz:
https://doaj.org/article/6f727b65914f4b40892e40872886e94a
Autor:
Zhongxiao Li, Bin Zhang, Jia Jia Chan, Hossein Tabatabaeian, Qing Yun Tong, Xiao Hong Chew, Xiaonan Fan, Patrick Driguez, Charlene Chan, Faith Cheong, Shi Wang, Bei En Siew, Ian Jse-Wei Tan, Kai-Yin Lee, Bettina Lieske, Wai-Kit Cheong, Dennis Kappei, Ker-Kan Tan, Xin Gao, Yvonne Tay
SummaryColorectal cancer (CRC) is the second leading cause of cancer death worldwide. In recent years, short-read single-cell RNA sequencing (scRNA-seq) has been instrumental in deciphering tumor cell heterogeneities. However, these studies only enab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::164d871344c44357378d920899e1d765
https://doi.org/10.1101/2023.04.21.536771
https://doi.org/10.1101/2023.04.21.536771