Zobrazeno 1 - 10
of 203
pro vyhledávání: '"Charleen T. Chu"'
Publikováno v:
Translational Neurodegeneration, Vol 11, Iss 1, Pp 1-14 (2022)
Abstract Glutamate is the most commonly engaged neurotransmitter in the mammalian central nervous system, acting to mediate excitatory neurotransmission. However, high levels of glutamatergic input elicit excitotoxicity, contributing to neuronal cell
Externí odkaz:
https://doaj.org/article/32f4d8a53be346279ff60d34a98545d4
Autor:
Osorio Lopes Abath Neto, Zachary A. Koretz, Abigail I. Wald, Pamela P. Rath, Marina Nikiforova, Charleen T. Chu
Publikováno v:
American Journal of Ophthalmology Case Reports, Vol 27, Iss , Pp 101599- (2022)
Purpose: To describe a case of iris metastasis as the initial presentation of clear cell renal cell carcinoma, and to discuss molecular profiling of both the metastasis and primary kidney tumor. Observations: We report a patient with blurred vision w
Externí odkaz:
https://doaj.org/article/5ad655f0ce394d05a15f09c259f0566e
Autor:
Charleen T. Chu
Publikováno v:
Neurobiology of Disease, Vol 122, Iss , Pp 23-34 (2019)
Over the past 20 years, the concept of mammalian autophagy as a nonselective degradation system has been repudiated, due in part to important discoveries in neurodegenerative diseases, which opened the field of selective autophagy. Protein aggregates
Externí odkaz:
https://doaj.org/article/573b8c222561482da5db12940e7a9f53
Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 26, Iss , Pp 100712- (2021)
Congenital corneal opacities (CCO) are a group of blinding corneal disorders, where the underlying molecular mechanisms are poorly understood. Phenotyping through specialized imaging and histopathology analysis, together with assessment of key transc
Externí odkaz:
https://doaj.org/article/3365da03458e4e8bba64953450b7a1dd
Publikováno v:
American Journal of Ophthalmology Case Reports, Vol 19, Iss , Pp 100816- (2020)
Purpose: To describe a rare case of early sympathetic ophthalmia that presented 5 days after penetrating injury. Observations: A 13-year-old boy presented with a penetrating left globe injury from a BB metallic projectile that was emergently repaired
Externí odkaz:
https://doaj.org/article/bef65d771f4c4f05b6d46b29116f665a
Publikováno v:
Frontiers in Neuroscience, Vol 12 (2018)
Dysregulation of calcium homeostasis has been linked to multiple neurological diseases. In addition to excitotoxic neuronal cell death observed following stroke, a growing number of studies implicate excess excitatory neuronal activity in chronic neu
Externí odkaz:
https://doaj.org/article/0e4134816449461eb058f2edcf90e8ca
Autor:
Charleen T. Chu
Publikováno v:
Neurobiology of Disease, Vol 122, Iss , Pp 1-2 (2019)
Externí odkaz:
https://doaj.org/article/7dd6284d083a4696893d8a1231bff3d2
Autor:
Marko Kostic, Marthe H.R. Ludtmann, Hilmar Bading, Michal Hershfinkel, Erin Steer, Charleen T. Chu, Andrey Y. Abramov, Israel Sekler
Publikováno v:
Cell Reports, Vol 13, Iss 2, Pp 376-386 (2015)
Mitochondrial Ca2+ overload is a critical, preceding event in neuronal damage encountered during neurodegenerative and ischemic insults. We found that loss of PTEN-induced putative kinase 1 (PINK1) function, implicated in Parkinson disease, inhibits
Externí odkaz:
https://doaj.org/article/e61a521041db4dec8e5a74e92341fd77
Autor:
Laurie H. Sanders, Jennifer McCoy, Xiaoping Hu, Pier G. Mastroberardino, Bryan C. Dickinson, Christopher J. Chang, Charleen T. Chu, Bennett Van Houten, J.T. Greenamyre
Publikováno v:
Neurobiology of Disease, Vol 70, Iss , Pp 214-223 (2014)
DNA damage can cause (and result from) oxidative stress and mitochondrial impairment, both of which are implicated in the pathogenesis of Parkinson's disease (PD). We therefore examined the role of mitochondrial DNA (mtDNA) damage in human postmortem
Externí odkaz:
https://doaj.org/article/a3e0fb76bd764bb882e1a79cace17569
Autor:
Bill B. Chen, Tiffany A. Coon, Jennifer R. Glasser, Chunbin Zou, Bryon Ellis, Tuhin Das, Alison C. McKelvey, Shristi Rajbhandari, Travis Lear, Christelle Kamga, Sruti Shiva, Chenjian Li, Joseph M. Pilewski, Jason Callio, Charleen T. Chu, Anuradha Ray, Prabir Ray, Yulia Y. Tyurina, Valerian E. Kagan, Rama K. Mallampalli
Publikováno v:
Cell Reports, Vol 7, Iss 2, Pp 476-487 (2014)
Summary: Acute lung injury (ALI) is linked to mitochondrial injury, resulting in impaired cellular oxygen utilization; however, it is unknown how these events are linked on the molecular level. Cardiolipin, a mitochondrial-specific lipid, is generate
Externí odkaz:
https://doaj.org/article/f58f4fba805b4b1fa45cbc1c553cb1b9