Patient-derived monoclonal antibody neutralizes SARS-CoV-2 Omicron variants and confers full protection in monkeys

Autor: Craig Fenwick, Priscilla Turelli, Dongchun Ni, Laurent Perez, Kelvin Lau, Cécile Herate, Romain Marlin, Erica Lana, Céline Pellaton, Charlène Raclot, Line Esteves-Leuenberger, Jérémy Campos, Alex Farina, Flurin Fiscalini, Nathalie Dereuddre-Bosquet, Francis Relouzat, Rana Abdelnabi, Caroline S. Foo, Johan Neyts, Pieter Leyssen, Yves Lévy, Florence Pojer, Henning Stahlberg, Roger LeGrand, Didier Trono, Giuseppe Pantaleo

Publikováno v: Nature Microbiology

The SARS-CoV-2 Omicron variant has very high levels of transmission, is resistant to neutralization by authorized therapeutic human monoclonal antibodies (mAb) and is less sensitive to vaccine-mediated immunity. To provide additional therapies agains

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aa2d8d308478607f5a9bccdf91a9cc8
https://lirias.kuleuven.be/handle/20.500.12942/701230

De novodesign of site-specific protein interactions with learned surface fingerprints

Autor: Pablo Gainza, Sarah Wehrle, Alexandra Van Hall-Beauvais, Anthony Marchand, Andreas Scheck, Zander Harteveld, Stephen Buckley, Dongchun Ni, Shuguang Tan, Freyr Sverrisson, Casper Goverde, Priscilla Turelli, Charlène Raclot, Alexandra Teslenko, Martin Pacesa, Stéphane Rosset, Sandrine Georgeon, Jane Marsden, Aaron Petruzzella, Kefang Liu, Zepeng Xu, Yan Chai, Pu Han, George F. Gao, Elisa Oricchio, Beat Fierz, Didier Trono, Henning Stahlberg, Michael Bronstein, Bruno E. Correia

Physical interactions between proteins are essential for most biological processes governing life. However, the molecular determinants of such interactions have been challenging to understand, even as genomic, proteomic, and structural data grows. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ae2dd2d3757cef1923a6c645e8be5972
https://doi.org/10.1101/2022.06.16.496402

Seroprevalence of anti-SARS-CoV-2 antibodies and cross-variant neutralization capacity after the Omicron BA.2 wave in Geneva, Switzerland: a population-based study

Autor: María-Eugenia Zaballa, Javier Perez-Saez, Carlos de Mestral, Nick Pullen, Julien Lamour, Priscilla Turelli, Charlène Raclot, Hélène Baysson, Francesco Pennacchio, Jennifer Villers, Julien Duc, Viviane Richard, Roxane Dumont, Claire Semaani, Andrea Jutta Loizeau, Clément Graindorge, Elsa Lorthe, Jean-François Balavoine, Didier Pittet, Manuel Schibler, Nicolas Vuilleumier, François Chappuis, Omar Kherad, Andrew S. Azman, Klara M. Posfay-Barbe, Laurent Kaiser, Didier Trono, Silvia Stringhini, Idris Guessous, Isabelle Arm-Vernez, Andrew S Azman, Delphine Bachmann, Antoine Bal, Michael Balavoine, Rémy P Barbe, Lison Beigbeder, Julie Berthelot, Patrick Bleich, Livia Boehm, Gaëlle Bryand, Prune Collombet, Sophie Coudurier-Boeuf, Delphine Courvoisier, Alain Cudet, Vladimir Davidovic, Paola D'ippolito, Richard Dubos, Isabella Eckerle, Nacira El Merjani, Antoine Flahault, Natalie Francioli, Marion Frangville, Séverine Harnal, Samia Hurst, Pierre Lescuyer, Arnaud G L'Huillier, François L'Huissier, Chantal Martinez, Lucie Ménard, Ludovic Metral-Boffod, Alexandre Moulin, Mayssam Nehme, Natacha Noël, Klara M Posfay-Barbe, Géraldine Poulain, Caroline Pugin, Frederic Rinaldi, Déborah Rochat, Irine Sakvarelidze, Khadija Samir, Hugo Santa Ramirez, Etienne Satin, Philippe Schaller, Stephanie Schrempft, Stéphanie Testini, Déborah Urrutia-Rivas, Charlotte Verolet, Pauline Vetter, Guillemette Violot, Ania Wisniak, Sabine Yerly

Publikováno v: The Lancet Regional Health - Europe. 24:100547

More than two years into the COVID-19 pandemic, most of the population has developed anti-SARS-CoV-2 antibodies from infection and/or vaccination. However, public health decision-making is hindered by the lack of up-to-date and precise characterizati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::263d6ae9daa9036059993c871efb6c75
https://doi.org/10.1016/j.lanepe.2022.100547

A multiplexed high-throughput neutralization assay reveals a lack of activity against multiple variants after SARS-CoV-2 infection

Autor: Florence Pojer, Charlène Raclot, Jérémy Campos, Giuseppe Pantaleo, Priscilla Turelli, Céline Pellaton, Craig Fenwick, Valeria Cagno, Alex Farina, Didier Trono

The detection of SARS-CoV-2-specific antibodies in the serum of an individual indicates prior infection or vaccination. However, it provides limited insight into the protective nature of this immune response. Neutralizing antibodies recognizing the v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e144dd600d088db9a7915b152aa2eae1
https://doi.org/10.1101/2021.04.08.21255150

S-Acylation Controls SARS-CoV-2 Membrane Lipid Organization and Enhances Infectivity

Autor: Francisco S. Mesquita, Laurence Abrami, Oksana Sergeeva, Priscilla Turelli, Béatrice Kunz, Charlène Raclot, Jonathan Paz Montoya, Luciano A. Abriata, Matteo Dal Peraro, Didier Trono, Giovanni D’Angelo, F. Gisou van der Goot

Publikováno v: SSRN Electronic Journal.

SARS-CoV-2 virions are surrounded by a lipid bilayer which contains membrane proteins such as Spike, responsible for target-cell binding and virus fusion, the envelope protein E and the accessory protein Orf3a. Here, we show that during SARS-CoV-2 in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e81fca0080a421dfffd6331c984fae1b
https://doi.org/10.2139/ssrn.3820042