Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Charlène, Gadais"'
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 19, Iss 1, Pp 245-281 (2023)
Terpene compounds probably represent the most diversified class of secondary metabolites. Some classes of terpenes, mainly diterpenes (C20) and sesterterpenes (C25) and to a lesser extent sesquiterpenes (C15), share a common bicyclo[3.6.0]undecane co
Externí odkaz:
https://doaj.org/article/ce614646b1c2408886748ab195c5000e
Autor:
Charlène Gadais, Justyna Piekielna-Ciesielska, Jolien De Neve, Charlotte Martin, Anna Janecka, Steven Ballet
Publikováno v:
Molecules, Vol 26, Iss 17, p 5406 (2021)
Opioid agonists are well-established analgesics, widely prescribed for acute but also chronic pain. However, their efficiency comes with the price of drastically impacting side effects that are inherently linked to their prolonged use. To answer thes
Externí odkaz:
https://doaj.org/article/94ab8e3827234a1e9280634ddfec46e4
Autor:
Kevin Van holsbeeck, Baptiste Fischer, Simon Gonzalez, Charlène Gadais, Wim Versées, José C. Martins, Charlotte Martin, Alexandre Wohlkönig, Jan Steyaert, Steven Ballet
Publikováno v:
Angewandte Chemie.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c9cdc278989a36dd13a2d0c2f80d76e
https://doi.org/10.1002/ange.202219095
https://doi.org/10.1002/ange.202219095
Autor:
Kevin Van holsbeeck, Baptiste Fischer, Simon Gonzalez, Charlène Gadais, Wim Versées, José C. Martins, Charlotte Martin, Alexandre Wohlkönig, Jan Steyaert, Steven Ballet
RAS proteins control various intracellular signaling networks. Mutations at specific locations were shown to stabilize their active GTP-bound state, which is associated with the development of multiple cancers. An attractive approach to modulate RAS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c403c0e9d8d035aaa711c410d457f5d2
https://doi.org/10.1101/2022.12.09.519747
https://doi.org/10.1101/2022.12.09.519747
Autor:
Charlène Gadais, Evelyne Chelain, Nathalie Lensen, Thierry Brigaud, Sitan Diarra, Clément Sanchez, Andrea Bordessa
Publikováno v:
Organic & Biomolecular Chemistry. 19:6771-6775
Enantiopure α-Tfm-proline and α-Tfm-pipecolic acid were synthesized starting from commercially available diesters and ethyl trifluoroacetate. A Strecker type reaction on intermediate chiral Tfm-oxazolo-pyrrolidine and -piperidine provided the corre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eb7f7454019c1346f66c7c839445ef8
https://doi.org/10.1039/d1ob01173a
https://doi.org/10.1039/d1ob01173a
Autor:
Charlène Gadais, Clément Sanchez, Sylvaine Girard, Gregory Chaume, Thierry Brigaud, Evelyne Chelain
Publikováno v:
Organic Letters. 23:382-387
The straightforward synthesis of enantiopure 5-(R)-and 5-(S)-trifluoromethylproline is reported. The key steps are a Ruppert-Prakash reagent addition on l-pyroglutamic esters followed by an elimination reaction and a selective reduction. The solution
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1846ac1eb055d0cc9b8d3290e2f77c11
https://doi.org/10.1021/acs.orglett.0c03880
https://doi.org/10.1021/acs.orglett.0c03880
Autor:
Charlène Gadais, Justyna Piekielna-Ciesielska, Jolien De Neve, Charlotte Martin, Anna Janecka, Steven Ballet
Publikováno v:
Molecules
Molecules, 2021, 26 (17), pp.5406. ⟨10.3390/molecules26175406⟩
Molecules, Vol 26, Iss 5406, p 5406 (2021)
Vrije Universiteit Brussel
Volume 26
Issue 17
Molecules, 2021, 26 (17), pp.5406. ⟨10.3390/molecules26175406⟩
Molecules, Vol 26, Iss 5406, p 5406 (2021)
Vrije Universiteit Brussel
Volume 26
Issue 17
Opioid agonists are well-established analgesics, widely prescribed for acute but also chronic pain. However, their efficiency comes with the price of drastically impacting side effects that are inherently linked to their prolonged use. To answer thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::db4713abc407f73f5cff03ba359f5172
https://hal.science/hal-03367748/file/molecules-26-05406.pdf
https://hal.science/hal-03367748/file/molecules-26-05406.pdf
Autor:
Clément A, Sanchez, Charlène, Gadais, Grégory, Chaume, Sylvaine, Girard, Evelyne, Chelain, Thierry, Brigaud
Publikováno v:
Organic letters. 23(2)
The straightforward synthesis of enantiopure 5-(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5893d3421d123317dc79f9d22a170f53
https://pubmed.ncbi.nlm.nih.gov/33369434
https://pubmed.ncbi.nlm.nih.gov/33369434
Autor:
Karlijn Hollanders, Clarence Wybon, Charlène Gadais, Evelien Renders, Steven Ballet, Dario Masullo, Wouter A. Herrebout, Charlotte Martin, Laurent Van Raemdonck, Bert U. W. Maes
Publikováno v:
ACS catalysis
A chemoselective and catalytic transamidation for peptide synthesis is described. Transamidation under Zn catalysis is chemoselectively achieved by amino acid amide/peptidic amide derivatization with a tert-butyl nicotinate (tBu-nic) directing group.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ee88d807d481d220c3bedb894615ab4
https://biblio.vub.ac.be/vubir/zncatalyzed-nicotinatedirected-transamidations-in-peptide-synthesis(36ea1b70-c248-486b-bc88-0ad0d7233969).html
https://biblio.vub.ac.be/vubir/zncatalyzed-nicotinatedirected-transamidations-in-peptide-synthesis(36ea1b70-c248-486b-bc88-0ad0d7233969).html
Autor:
Julien Pytkowicz, Emmanuelle Devillers, Thierry Brigaud, Evelyne Chelain, Charlène Gadais, Vincent Gasparik
Publikováno v:
ChemBioChem. 19:1026-1030
In order to achieve accurate determination of the local hydrophobicity increases in peptide sequences produced by incorporation of trifluoromethylated amino acids (TfmAAs), the chromatographic hydrophobicity indexes (ϕ0 ) of three series of tripepti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c46763fca8c8621f2ca701ac8dec175d
https://doi.org/10.1002/cbic.201800088
https://doi.org/10.1002/cbic.201800088