Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Charis-Patricia Segeritz"'
Autor:
Rute A Tomaz, Ekaterini D Zacharis, Fabian Bachinger, Annabelle Wurmser, Daniel Yamamoto, Sandra Petrus-Reurer, Carola M Morell, Dominika Dziedzicka, Brandon T Wesley, Imbisaat Geti, Charis-Patricia Segeritz, Miguel C de Brito, Mariya Chhatriwala, Daniel Ortmann, Kourosh Saeb-Parsy, Ludovic Vallier
Publikováno v:
eLife, Vol 11 (2022)
Production of large quantities of hepatocytes remains a major challenge for a number of clinical applications in the biomedical field. Directed differentiation of human pluripotent stem cells (hPSCs) into hepatocyte-like cells (HLCs) provides an adva
Externí odkaz:
https://doaj.org/article/07a94c8ea33a4c4d9ca24e8d7b3c1339
Autor:
Andrew A. Wilson, Lei Ying, Marc Liesa, Charis-Patricia Segeritz, Jason A. Mills, Steven S. Shen, Jyhchang Jean, Geordie C. Lonza, Derek C. Liberti, Alex H. Lang, Jean Nazaire, Adam C. Gower, Franz-Josef Müeller, Pankaj Mehta, Adriana Ordóñez, David A. Lomas, Ludovic Vallier, George J. Murphy, Gustavo Mostoslavsky, Avrum Spira, Orian S. Shirihai, Maria I. Ramirez, Paul Gadue, Darrell N. Kotton
Publikováno v:
Stem Cell Reports, Vol 4, Iss 5, Pp 873-885 (2015)
Induced pluripotent stem cells (iPSCs) provide an inexhaustible source of cells for modeling disease and testing drugs. Here we develop a bioinformatic approach to detect differences between the genomic programs of iPSCs derived from diseased versus
Externí odkaz:
https://doaj.org/article/44a5e635235f4b51ae3af9f3f2858bc2
Autor:
Carmen Radeke, Raphaël Pons, Marko Mihajlovic, Jonas R. Knudsen, Sarkhan Butdayev, Paul J. Kempen, Charis-Patricia Segeritz, Thomas L. Andresen, Christian K. Pehmøller, Thomas E. Jensen, Johan U. Lind
Publikováno v:
ACS applied materialsinterfaces.
For three-dimensional (3D) bioprinting to fulfill its promise and enable the automated fabrication of complex tissue-mimicking constructs, there is a need for developing bioinks that are not only printable and biocompatible but also have integrated c
Autor:
Rute A. Tomaz, Ekaterini D. Zacharis, Fabian Bachinger, Annabelle Wurmser, Daniel Yamamoto, Sandra Petrus-Reurer, Carola M. Morell, Dominika Dziedzicka, Brandon T. Wesley, Imbisaat Geti, Charis-Patricia Segeritz, Miguel Cardoso de Brito, Mariya Chhatriwala, Daniel Ortmann, Kourosh Saeb-Parsy, Ludovic Vallier
Funder: UK Regenerative Medicine Platform
Funder: Wellcome Trust
Funder: Wellcome - MRC Cambridge Stem Cell Institute, University of Cambridge
Funder: Chan Zuckerberg Initiative
Production of large quantities of hepatocytes remain
Funder: Wellcome Trust
Funder: Wellcome - MRC Cambridge Stem Cell Institute, University of Cambridge
Funder: Chan Zuckerberg Initiative
Production of large quantities of hepatocytes remain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e023f6edb4361b6326f9a402df618911
Autor:
Rute A Tomaz, Ekaterini D Zacharis, Fabian Bachinger, Annabelle Wurmser, Daniel Yamamoto, Sandra Petrus-Reurer, Carola M Morell, Dominika Dziedzicka, Brandon T Wesley, Imbisaat Geti, Charis-Patricia Segeritz, Miguel C de Brito, Mariya Chhatriwala, Daniel Ortmann, Kourosh Saeb-Parsy, Ludovic Vallier
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28facff8441c30120a332f8a8b75df26
https://doi.org/10.7554/elife.71591.sa2
https://doi.org/10.7554/elife.71591.sa2
Autor:
Philipp Kramer, Baltasar Lucendo-Villarin, Aishwariya Sharma, Yu Wang, Nan-Linda Ding, Agnes Sorteberg, David C. Hay, Charis-Patricia Segeritz, Jose Meseguer-Ripolles
Publikováno v:
Meseguer Ripolles, J, Wang, Y, Sorteberg, A, Sharma, A, Ding, N-L, Lucendo Villarin, B, Krämer, P, Segeritz, C-P & Hay, D 2020, ' Hepatic Progenitor Specification from Pluripotent Stem Cells Using a Defined Differentiation System ', Journal of Visualized Experiments (JoVE), no. 159, e61256 . https://doi.org/10.3791/6125
Liver disease is an escalating global health issue. While liver transplantation is an effective mode of therapy, patient mortality has increased due to shortages in donor organ availability. Organ scarcity also affects the routine supply of human hep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16915bc9d5f66d4da4f415578994cbdd
https://hdl.handle.net/20.500.11820/b6706315-b9e5-4805-bd50-a926d04bbf17
https://hdl.handle.net/20.500.11820/b6706315-b9e5-4805-bd50-a926d04bbf17
Publikováno v:
Toxicological Sciences. 164:229-239
Experimental drugs need to be screened for safety within time constraints. Hepatotoxicity is one concerning contributor to the failure of investigational new drugs and a major rationale for postmarketing withdrawal decisions. Ethical considerations i
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Numerous in vitro models endeavour to mimic the characteristics of primary human hepatocytes for applications in regenerative medicine and pharmaceutical science. Mature hepatocyte-like cells (HLCs) derived from human induced pluripotent stem cells (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e63278143386e903736e0f46a6709565
https://www.repository.cam.ac.uk/handle/1810/290440
https://www.repository.cam.ac.uk/handle/1810/290440
Autor:
Ludovic Vallier, Andrew A. Wilson, Jean Nazaire, David A. Lomas, Pankaj Mehta, Geordie C. Lonza, Paul Gadue, George J. Murphy, Derek C. Liberti, Jyh-Chang Jean, Avrum Spira, Adriana Ordóñez, Charis Patricia Segeritz, Lei Ying, Maria I. Ramirez, Marc Liesa, Alex H. Lang, Steven S. Shen, Gustavo Mostoslavsky, Orian S. Shirihai, Adam C. Gower, Jason A. Mills, Darrell N. Kotton, Franz Josef Müeller
Publikováno v:
Stem Cell Reports, Vol 4, Iss 5, Pp 873-885 (2015)
Stem Cell Reports
Stem Cell Reports
Summary Induced pluripotent stem cells (iPSCs) provide an inexhaustible source of cells for modeling disease and testing drugs. Here we develop a bioinformatic approach to detect differences between the genomic programs of iPSCs derived from diseased
Publikováno v:
Hepatology
Liver disease is a leading cause of death in the Western world. However, our insight into the underlying disease mechanisms and the development of novel therapeutic agents has been hindered by limited availability of primary tissue, intraspecies vari