Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Charis Pericleous"'
Autor:
Marie B. Lang, Kit-Yi Leung, Nicholas D.E. Greene, Kerri M. Malone, Gaye Saginc, Anna M. Randi, Allan Kiprianos, Robert T. Maughan, Charis Pericleous, Justin C. Mason
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
ObjectivesThe disease-modifying anti-rheumatic drug methotrexate (MTX) is recognized to reduce cardiovascular risk in patients with systemic inflammatory diseases. However, the molecular basis for these cardioprotective effects remains incompletely u
Externí odkaz:
https://doaj.org/article/5d363a763a9c431a9c93d4a8e3417ea0
Autor:
Anisur Rahman, Ian Giles, Chris Wincup, Bahar Artim-Esen, Thomas McDonnell, Charis Pericleous, Raj Amarnani, Ian Mackie, Carina Spicer, Hajar Jbari, Valentina A Spiteri
Publikováno v:
Lupus Science and Medicine, Vol 9, Iss 1 (2022)
Objectives The significance of antibodies directed against activated factor X (FXa) and thrombin (Thr) in patients with SLE and/or antiphospholipid syndrome (APS) is unknown. FXa and Thr are coregulated by antithrombin (AT) and activate complement. T
Externí odkaz:
https://doaj.org/article/785035e9ebeb4c33b2e29ad930994361
Autor:
Rohan Willis, Thomas C. R. McDonnell, Charis Pericleous, Emilio B. Gonzalez, Alvaro Schleh, Zurina Romay-Penabad, Ian P. Giles, Anisur Rahman
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Antiphospholipid syndrome (APS) is an autoimmune disorder in which autoantibodies cause clinical effects of vascular thrombosis and pregnancy morbidity. The only evidence-based treatments are anticoagulant medications such as warfarin and heparin. Th
Externí odkaz:
https://doaj.org/article/b1d23db02f4044e2816293b90112e7f5
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 2, p 1331 (2023)
Antiphospholipid syndrome (APS) is an acquired highly prothrombotic disorder in which thrombo-inflammatory antiphospholipid antibodies (aPL) cause thrombosis via multiple mechanisms, including endothelial damage and activation. Obstetric complication
Externí odkaz:
https://doaj.org/article/6c48ac8c54c0401584fd0520b7201463
Autor:
Laura A. Benjamin, Ross W. Paterson, Rachel Moll, Charis Pericleous, Rachel Brown, Puja R. Mehta, Dilan Athauda, Oliver J. Ziff, Judith Heaney, Anna M. Checkley, Catherine F. Houlihan, Michael Chou, Amanda J. Heslegrave, Arvind Chandratheva, Benedict D. Michael, Kaj Blennow, Vinojini Vivekanandam, Alexander Foulkes, Catherine J. Mummery, Michael P. Lunn, Stephen Keddie, Moira J. Spyer, Tom Mckinnon, Melanie Hart, Francesco Carletti, Hans Rolf Jäger, Hadi Manji, Michael S. Zandi, David J. Werring, Eleni Nastouli, Robert Simister, Tom Solomon, Henrik Zetterberg, Jonathan M. Schott, Hannah Cohen, Maria Efthymiou
Publikováno v:
EClinicalMedicine, Vol 39, Iss , Pp 101070- (2021)
Background: A high prevalence of antiphospholipid antibodies has been reported in case series of patients with neurological manifestations and COVID-19; however, the pathogenicity of antiphospholipid antibodies in COVID-19 neurology remains unclear.
Externí odkaz:
https://doaj.org/article/3eef6c9f06c243ceb51ecb95ba2fa15f
Autor:
Blerina Ahmetaj-Shala, Isra Marei, Ryota Kawai, Stephen Rothery, Charis Pericleous, Nura A. Mohamed, Hime Gashaw, Kalliopi Bokea, Jake Samuel, Annabelle Vandenheste, Fisnik Shala, Nicholas S. Kirkby, Jane A. Mitchell
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Blood outgrowth smooth muscle cells (BO-SMCs) offer the means to study vascular cells without the requirement for surgery providing opportunities for drug discovery, tissue engineering, and personalized medicine. However, little is known about these
Externí odkaz:
https://doaj.org/article/860589e872164217bdf7e5b290da3559
Autor:
Akif A. Khawaja, Deborah L. W. Chong, Jagdeep Sahota, Theresia A. Mikolasch, Charis Pericleous, Vera M. Ripoll, Helen L. Booth, Saif Khan, Manuel Rodriguez-Justo, Ian P. Giles, Joanna C. Porter
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Neutrophilic inflammation correlates with mortality in fibrotic interstitial lung disease (ILD) particularly in the most severe form, idiopathic pulmonary fibrosis (IPF), although the underlying mechanisms remain unclear. Neutrophil function is modul
Externí odkaz:
https://doaj.org/article/5210d6d6f7624959a7d494252cd021f5
Autor:
Thomas C. R. McDonnell, Rohan Willis, Charis Pericleous, Vera M. Ripoll, Ian P. Giles, David. A. Isenberg, Allan R. Brasier, Emilio B. Gonzalez, Elizabeth Papalardo, Zurina Romay-Penabad, Mohammad Jamaluddin, Yiannis Ioannou, Anisur Rahman
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
APS is an autoimmune disease in which antiphospholipid antibodies (aPL) cause vascular thrombosis and pregnancy morbidity. In patients with APS, aPL exert pathogenic actions by binding serum beta-2-glycoprotein I (β2GPI) via its N-terminal domain I
Externí odkaz:
https://doaj.org/article/5dbe595d033240e5b72049f6a3eda9b1
Autor:
Thomas McDonnell, Bahar Artim-Esen, Chris Wincup, Vera M. Ripoll, David Isenberg, Ian P. Giles, Anisur Rahman, Charis Pericleous
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Antiphospholipid antibodies (aPL), the serological hallmark of antiphospholipid syndrome (APS), are a heterogeneous group of autoantibodies raised against circulating blood proteins. Of these proteins, the phospholipid-binding b2-glycoprotein I (β2G
Externí odkaz:
https://doaj.org/article/0ece953eefd0478c872233844c9d1904
Autor:
Maria Gabriella Raimondo, Charis Pericleous, Anna Radziszewska, Maria Orietta Borghi, Silvia Pierangeli, Pier Luigi Meroni, Ian Giles, Anisur Rahman, Yiannis Ioannou
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0186513 (2017)
Domain I (DI) of beta-2-glycoprotein I (β2GPI) contains the immunodominant epitope for pathogenic antiphospholipid antibodies (aPL). DI is exposed in the linear form of the molecule but not in the circular form that comprises 90% of serum β2GPI. Th
Externí odkaz:
https://doaj.org/article/8e2b63c007d34c27b62428d71f05b970