Patient-based transcriptome-wide analysis identify interferon and ubiquination pathways as potential predictors of influenza A disease severity.

Autor: Long Truong Hoang, Thomas Tolfvenstam, Eng Eong Ooi, Chiea Chuen Khor, Ahmand Nazri Mohamed Naim, Eliza Xin Pei Ho, Swee Hoe Ong, Heiman F Wertheim, Annette Fox, Chau Van Vinh Nguyen, Ngoc My Nghiem, Tuan Manh Ha, Anh Thi Ngoc Tran, Paul Tambayah, Raymond Lin, Chariya Sangsajja, Weerawat Manosuthi, Chareon Chuchottaworn, Piamlarp Sansayunh, Tawee Chotpitayasunondh, Piyarat Suntarattiwong, Kulkanya Chokephaibulkit, Pilaipan Puthavathana, Menno D de Jong, Jeremy Farrar, H Rogier van Doorn, Martin Lloyd Hibberd

Publikováno v: PLoS ONE, Vol 9, Iss 11, p e111640 (2014)

The influenza A virus is an RNA virus that is responsible for seasonal epidemics worldwide with up to five million cases of severe illness and 500,000 deaths annually according to the World Health Organization estimates. The factors associated with s

Externí odkaz: https://doaj.org/article/721c5ac7ea8b4dca80771467ae2821e3

Effect of double dose oseltamivir on clinical and virological outcomes in children and adults admitted to hospital with severe influenza: double blind randomised controlled trial

Autor: Dadang Hudaya Somasetia, Lu Viet Ho, Jeremy Farrar, Elizabeth Higgs, Walter Rj Taylor, Pham Phuong Bui, Iko Safika, Yong Rongrungruang, Elaine Stockwell, Tan Thanh Tran, Niklas Lindegardh, Thanh Phong Nguyen, Thi Thuy Chinh Bkrong Nguyen, Quoc Chinh Luong, Nguyen Truc Nhu Le, Van Kinh Nguyen, Umaporn Chantbuddhiwet, Thi Thu Thao Le, Arto Yuwono Soeroto, Quoc Bao Vo, Winai Ratanasuwan, Sri Sudarwati, Kasia Stepniewska, Thi Thanh Dang, Quang Ha Do, Kulkanya Chokephaibulkit, Nicholas P. J. Day, Laura Merson, Thuy Ngan Tran, Chareon Chuchottaworn, Ngoc Quang Minh Ngo, H. Rogier van Doorn, Frederick G. Hayden, Anh Tuan Tran, Sondang Maryutka Sirait, Steve Wignall, Michael Polis, Moh Suhud Malik, Menno D. de Jong, Wasana Prasitsuebsai, Phuong Khanh Vo, Adria Rusli, Nguyen Nhat Trung Le, Prijanti Z Soepandi, Huu Khanh Truong, Paul A. Tambyah, Anh Tuan Le, Quynh Huong Tran, Tjandra Yoga Aditama, Thi Ngoc Anh Tran, Yee Sin Leo, Rismali Agus, Patama Sutha, Thi San Luong, Thi Tam Duong, Xuan Vu Bui, Vinh Diet Tran, Quoc Thai Nguyen, Tinh Hien Tran, Thanh Liem Nguyen, Thi Tam Cao, Endang Rahayu Sedyaningsih, Tawee Chotpitayasunondh, Thi Ty Hang Vu, Lawrence Lee, An Nguyet Lam, Hong Nhien Trinh, Piamlarp Sansayunh, Ngoc Tu Anh Nguyen, My Ngoc Nghiem, Thi Thanh Ha Nguyen, Weerawat Manosuthi, Thi Tam Uyen Le, Tini T Maskoen, Viet Hung Pham, Annette Fox, Piyarat Suntarattiwong, Supichaya Netsawang, Thi Hai Men Pham, Thi Hai Ninh Tran, Heiman L Wertheim, Xuan Ngoc Le, Thu Hien Pham, Ida Parwati, Juliet E. Bryant, C. Fukuda, Ngoc Phuc Nguyen, Dewi Murniati, Louis Yi Ann Chai, Phan Kim Thoa Le, Minh Hien Vo, Thi Hanh Le Nguyen, Van Hao Nguyen, Chau Viet Do, Yovita Hartantri, Quoc Thinh Le, Nirun Vanprapar, Vu Huy Bui, Nicholas J. White, Viet Tung Cao, Orasri Wittawatmongkol, Djatnika Setiabudi, Thi Tham Nguyen, Thi Kim Thoa Ho, Trung Cap Nguyen, Vivi Setiawaty, Duy Khuong Huynh, Thi Mai Thanh Doan, Thi Thu Loan Tran, Viet Hung Dau, Huu Phuc Phan, Thi Thuy Ha Lam, Hadi Jusuf, Hong Ha Nguyen, Vu Nguyen, Van Tuyet Hoang, Agung P Sutiyoso, Thi My Dung Tran, Ika Priatni, Sila Wiweka, Sardikin Giriputro, Emmy Hermiyanti Pranggono, Anh Tuan Ho, Pilaipan Puthavathana, Kevin Baird, Erlina Burhan, Binh Bao Tinh Le, Kittima Bangpattanasiri, Thanomsak Anekthananon, Chariya Sangsajja, Sri Sulastri, Dale A. Fisher, Minh Qui Le, Peter Horby, Manh Tuan Ha, Raymond T. P. Lin, Trihono Trihono, Chau Thy Tieu, Thi Thuy Tran, Duc Hien Nguyen, Tu Qui Phan, Tran Dieu Hien Pham, Thanh Truong Nguyen, Dinh Phu Vu, Van Vinh Chau Nguyen, Tony Soetanto, John H. Beigel, Lia G Partakusuma

Publikováno v: BMJ (Clinical research ed.), 346. British Medical Association

Objective To investigate the validity of recommendations in treatment guidelines to use higher than approved doses of oseltamivir in patients with severe influenza. Design Double blind randomised trial. Setting Thirteen hospitals in Indonesia, Singap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d0ce84d6fcee0f163735569421e125a
https://ora.ox.ac.uk/objects/uuid:cf596b3a-ea04-41cd-b489-35a1e1dfbbc6